Comparative in silico and protein-protein interaction network analysis of ATP1A1 gene

Progress in the field of bioinformatics is useful to understand the global network of genes and their protein products. In the present study, comparative analysis of ATP1A1 (ATPase Na +/K + Transporting Subunit Alpha 1) proteins of different livestock species were carried out using Bioinformatics tools. Genetic variants of the ATP1A1 gene have been suggested to be involved in the salt hypertension, feed intake, and essential hypertension, all of which may evidently affect heat production, heat loss and water mineral balance. The results of this study indicate that, most of physico-chemical properties were almost same in pig and sheep. The global network analysis of ATP1A1 gene by, STRING 10 tool speculated its interaction with several other proteins like - ATP1A2, ATP1A3, ATP1B1, ATP1B3, FXYD2 in different livestock species having high confidence score. The strong interaction was seen between ATP1A1 and ATP1B1 with a good high score in cattle. Molecular docking between ATP1A1 and ATP1B1 of cattle has been carried out. Conserved region was present in all the nine studied different livestock species protein sequences despite speciation due to evolution. The present study will further support to understand the role of associated proteins in various cellular pathways in cattle. This work is also useful for the study of structural and functional analysis of ATP1A1 protein.