کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8716107 | 1587878 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Disruption of the Epidermal Barrier Induces Regulatory T Cells via IL-33 in Mice
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کلمات کلیدی
CHSTNCBBMDCTEWLTregOXAAPCAMP2,4,6-trinitro-1-chlorobenzene - 2،4،6-ترینیترو-1-کلربرنزنTransepidermal water loss - از دست دادن آب دریچهOxazolone - اگزازولونContact hypersensitivity - تماس با افزایش حساسیتdiphtheria toxin - توکسین دیفتریRegulatory T cell - سلول T تنظیم کنندهbone marrow-derived dendritic cell - سلول های دندانیایی حاصل از استخوان مغز استخوانantigen presenting cell - سلولهای پردازنده آنتیژنAntimicrobial peptide - پپتیدهای ضدمیکروبی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
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چکیده انگلیسی
Disturbance of the epidermal barrier by UVR is associated with the release of antimicrobial peptides and inflammatory cytokines for the purpose of a danger response. On the other hand, UVR causes immunosuppression via regulatory T cells (Treg) that limit the inflammatory reaction. The concurrent induction of antimicrobial peptides and Treg by UVR may represent a counter-regulatory mechanism in response to barrier disruption, preventing microbial superinfection and sensitization to contact allergens, respectively, both of which cross impaired epidermis more easily. Thus, using a model of murine contact hypersensitivity we examined if disruption of the epidermal barrier only initiates similar counter-regulatory mechanisms via the generation of Treg. Sensitization through tape-stripped skin induced a weaker contact hypersensitivity response than in control mice. This was due to the induction of antigen-specific Treg, as demonstrated in adoptive transfer and depletion experiments utilizing DEREG mice. Treg induction by tape stripping was linked to the expression of the alarmin IL-33, as blockade of IL-33 exacerbated contact hypersensitivity, whereas injection of IL-33 inhibited contact hypersensitivity and induced Treg. These results demonstrate that epidermal barrier disruption, in addition to danger signals, induces regulatory events that prevent exaggerated skin inflammation and that IL-33 appears to be critically involved in this process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 138, Issue 3, March 2018, Pages 570-579
Journal: Journal of Investigative Dermatology - Volume 138, Issue 3, March 2018, Pages 570-579
نویسندگان
Anika Bruhs, Ehrhardt Proksch, Thomas Schwarz, Agatha Schwarz,