کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8870921 | 1622704 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tissue-specific metabolic responses of the pearl oyster Pinctada martensii exposed to benzo[a]pyrene
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
علوم زمین و سیارات
اقیانوس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tissue-specific metabolic responses of the pearl oyster Pinctada martensii exposed to benzo[a]pyrene Tissue-specific metabolic responses of the pearl oyster Pinctada martensii exposed to benzo[a]pyrene](/preview/png/8870921.png)
چکیده انگلیسی
Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is well known for its teratogenic, mutagenic and carcinogenic effects. In this study, we applied metabolomics to investigate the tissue-specific metabolic responses of the Pinctada martensii digestive glands and gills after a short-duration exposure to BaP (1â¯Î¼g/L and 10â¯Î¼g/L). After 72â¯h of exposure to BaP, the majority of metabolite changes were related to osmolytes, energy metabolites, and amino acids. BaP (1â¯Î¼g/L) accelerated energy deterioration and decreased osmotic regulation, while BaP (10â¯Î¼g/L) disturbed energy metabolism and increased osmotic stress in the digestive glands. Both BaP doses disturbed osmotic regulation and energy metabolism in the gills. BaP also induced neurotoxicity in both tissues. These findings demonstrated that BaP exhibited tissue-specific metabolic responses in P. martensii. The difference in these metabolite responses between the digestive glands and gills might prove to be suitable biomarkers for indicating exposure to specific marine pollutants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Marine Pollution Bulletin - Volume 131, Part A, June 2018, Pages 17-21
Journal: Marine Pollution Bulletin - Volume 131, Part A, June 2018, Pages 17-21
نویسندگان
Hao Chen, Xiaoping Diao, Hailong Zhou,