کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8951394 | 1645819 | 2018 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Relationship of Current Cognitive Activity to Brain Amyloid Burden and Glucose Metabolism
ترجمه فارسی عنوان
رابطه فعالیت فعلی شناختی با فشار آمیلوئید مغزی و متابولیسم گلوکز
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
مغز و اعصاب بالینی
چکیده انگلیسی
Several studies have investigated how lifetime cognitive engagement affects levels of amyloid-beta (Aβ) deposition in the brain. However, there has been some disagreement, leaving the relationship of cognitive activity (CA) to Aβ a largely open question. The present study investigated the relationship between CA, Aβ deposition, and glucose metabolism. One hundred nine cognitively normal participants underwent Pittsburgh Compound-B (PiB) and [18F]fluorodeoxyglucose-positron emission tomography and completed a questionnaire designed to measure current CA. Statistical analyses revealed significant differences in PiB retention between those in the high and low CA groups. Linear regression models revealed a significant negative relationship between PiB retention and CA and a significant positive relationship between glucose metabolism and CA. These data suggest that CA may have a direct beneficial effect on the pathophysiology of AD or reflect another underlying process that results in both higher CA and lower AD pathophysiology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Geriatric Psychiatry - Volume 26, Issue 9, September 2018, Pages 977-984
Journal: The American Journal of Geriatric Psychiatry - Volume 26, Issue 9, September 2018, Pages 977-984
نویسندگان
Clayton E. B.S., Dana Ph.D., Beth E. Ph.D., Julie Ph.D., Howard M.D., Ph.D., Oscar M.D., Brian M.S., Charles Ph.D., Davneet Ph.D., Ilyas Ph.D., Chester Ph.D., William M.D., Ph.D., Ann D. Ph.D.,