کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8951655 | 1645833 | 2018 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MicroRNA Signatures in Diagnosis and Prognosis of Cutaneous T-Cell Lymphoma
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کلمات کلیدی
CTCLPTCLcutaneous anaplastic large cell lymphomaAUC - AUCFFPE - MEPoverall survival - بقای کلformalin-fixed paraffin-embedded - فرمالین ثابت پارافین تعبیه شده استMycosis fungoides - قارچ MycosisCutaneous T cell lymphoma - لنفوم بدن انسان TPeripheral T-cell lymphoma - لنفوم سلول T سلولهای محیطیarea under the curve - منطقه تحت منحنیMicroRNA - میکرو RNA MiRNA - میکروRNA، ریزآرانای، miRNABID - پیشنهاد
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Cutaneous T cell lymphoma (CTCL) can have clinical and histological features resembling benign inflammatory dermatosis and can be difficult to diagnose. Very limited biomarkers are available for CTCL prognosis. We aimed to identify microRNA (miR) signatures to facilitate diagnostic and prognostic evaluations of CTCL. A cross-platform miR microarray identified 10 miRs that were differentially expressed between CTCL and benign inflammatory dermatosis patients. Subsequent reverse transcription polymerase chain reaction validation was used to generate a 5-miR-based diagnosing classifier, which showed high diagnostic accuracy in CTCL (area under the curve = 0.985 and 0.956 for training and testing set, respectively). Association between miR expressions and patient prognosis was studied. miR-155 and miR-200b were significantly associated with overall survival in CTCL patients, outperformed Ki-67. miR expressions were combined with Ki-67 to create a classifier for 5-year overall survival in CTCL patients. Our work provided miR signatures to facilitate CTCL diagnosis and prognosis with satisfying accuracy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 138, Issue 9, September 2018, Pages 2024-2032
Journal: Journal of Investigative Dermatology - Volume 138, Issue 9, September 2018, Pages 2024-2032
نویسندگان
Xiaoyan Shen, Bo Wang, Kejia Li, Lili Wang, Xiaoqing Zhao, Feng Xue, Ruofei Shi, Jie Zheng,