کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8994848 1114466 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Real-time near-infrared monitoring of content uniformity, moisture content, compact density, tensile strength, and young's modulus of roller compacted powder blends
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Real-time near-infrared monitoring of content uniformity, moisture content, compact density, tensile strength, and young's modulus of roller compacted powder blends
چکیده انگلیسی
A method for real-time in-line near-infrared (NIR) monitoring of roller compaction is reported. Multivariate analysis using partial least square projections to latent structures (PLS) was used to relate the spectral data with key compact attributes: content uniformity, moisture content, relative density, tensile strength, and Young's modulus. NIR calibration curves were generated using the spectral data collected on simulated ribbons, that is, tablets prepared under uni-axial compression, and tested on the data collected on another set of simulated ribbons and by monitoring the ribbons as they exited the roller compactor. For all compact attributes, the NIR predicted values agreed well with the values measured using a reference method. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 7, July 2005, Pages 1589-1597
نویسندگان
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