کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9011214 | 1560413 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bioactive pectic polysaccharides from Glinus oppositifolius (L.) Aug. DC., a Malian medicinal plant, isolation and partial characterization
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کلمات کلیدی
Rhamnogalacturonan IIArabinogalactanDMTPBSSRBCAG-IIarabinogalactan type IIGlcARHAFCSXylRG-IRG-IISEC/MALLSAG-IPMIIarabinogalactan type ILPSPBMCRhamnogalacturonan IFPLCFucFucoseGlcGalacturonic acid - اسید گالاکاتورونیکGlucuronic acid - اسید گلوکورونیکImmunomodulation - تنظیم ایمنی rhamnose - رامنوزfetal calf serum - سرم گوساله جنینfast protein liquid chromatography - سریع کروماتوگرافی مایع پروتئینperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیMass spectroscopy - طیف سنجی جرمیDulbecco's phosphate buffered saline - فسفات باسیل نمک Dulbeccolipopolysaccharide - لیپوپلی ساکاریدMannose - مانوزMan - مردPectin - پکتینGas chromatography - کروماتوگرافی گازیGal - گالGalA - گالاGalactose - گالاکتوزمی Xylose - گزیلوزsheep red blood cells - گلبول های قرمز گوسفندGlucose - گلوکز
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Glinus oppositifolius (L.) Aug. DC. (Aizoaceae) is a Malian medicinal plant used against various types of illnesses related to the immune response, like joint pains, inflammations, fever, malaria and wounds. Two pectin type polysaccharides, GOA1 and GOA2, being isolated from a 50 °C water extract from the aerial parts of Glinus oppositifolius were investigated for their activity towards the complement system and different leukocyte subsets because of the assumed effects on conditions related to the immune system. The polysaccharide polymer in GOA1 was shown to contain considerable amounts of the neutral sugars arabinose (26.4 mol%) and galactose (42.9 mol%), and methylation analysis indicated the presence of arabinogalactans type I (AG-I) and type II (AG-II). GOA2 was rich in galacturonic acid (68.3 mol%), along with rhamnose, arabinose and galactose. Structural studies indicated that rhamnose and galacturonic acid might constitute a rhamnogalacturonan backbone, often found in pectic substances, with side chains consisting of arabinose and galactose. Both GOA1 and GOA2 were shown to exhibit potent dose-dependent complement fixating activities, and induced chemotaxis of macrophages, T cells and NK cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 101, Issues 1â3, 3 October 2005, Pages 204-214
Journal: Journal of Ethnopharmacology - Volume 101, Issues 1â3, 3 October 2005, Pages 204-214
نویسندگان
Kari Tvete Inngjerdingen, Sylvi C. Debes, Marit Inngjerdingen, Sanya Hokputsa, Stephen E. Harding, Bent Rolstad, Terje E. Michaelsen, Drissa Diallo, Berit Smestad Paulsen,