کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9012629 | 1124991 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids
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کلمات کلیدی
PBSBCECFATP-binding cassette proteinsMK-571NBD1DMSO - DMSOP-glycoprotein - P-گلیکوپروتئینnucleotide-binding domain - دامنه اتصال دهنده نوکلئوتیدیDimethyl sulfoxide - دیمتیل سولفواکسیدErythrocyte membrane - غشای erythrocytephosphate buffer saline - فسفات بافر شورFlavonoids - فلاونوئیدهاMultidrug resistance - مقاومت چند داروییABC protein - پروتئین ABCmultidrug resistance-associated protein - پروتئین مرتبط با مقاومت چند دارویی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The influence of novel synthetic and plant origin flavonoids on activity of multidrug resistance-associated protein (MRP1) was investigated in human erythrocytes used as a cell model expressing MRP1 in plasma membrane. The fluorescent probe, BCPCF (2â², 7â²-bis-(3-carboxy-propyl)-5-(and-6)-carboxyfluorescein), was applied as a substrate for MRP1 multidrug resistance transporter. The effect of compounds belonging to different classes of natural flavonoids: flavone, flavonol, isoflavones and flavanolignan was compared with action of new synthetic derivatives of genistein. Most of the flavonoids showed strong or moderate ability to inhibit transport carried out by MRP1. Inhibitory properties of flavonoids were compared to the effects of indomethacin, probenecid and MK-571 known as MRP1 inhibitors. Studying the influence of new synthetic genistein derivatives on BCPCF transport we have found that the presence of hydrophobic groups substituting hydrogen of hydroxyl group at the position 4â² in ring B of isoflavone is more important for inhibitory properties than hydrophobic substitution at the position 7 in ring A. In case of naturally occurring isoflavones the replacement of hydrogen at position 4â² by hydrophobic ring structure seems also to be favourable for inhibition potency.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 77, Issue 15, 26 August 2005, Pages 1879-1891
Journal: Life Sciences - Volume 77, Issue 15, 26 August 2005, Pages 1879-1891
نویسندگان
Barbara Åania-Pietrzak, Krystyna Michalak, Andrzej B. Hendrich, Daniela MosiÄ
dz, Grzegorz Grynkiewicz, Noboru Motohashi, Yoshiaki Shirataki,