کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9016318 1128089 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mirtazapine and venlafaxine in the management of collateral psychopathology during alcohol detoxification
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Mirtazapine and venlafaxine in the management of collateral psychopathology during alcohol detoxification
چکیده انگلیسی
Symptoms of anxiety and depression are common in a large proportion of alcohol-abusing/dependent individuals during alcohol detoxification. The aim of this study was to examine the impact of a combined psychotherapeutic-psychopharmacological (either with mirtazapine or venlafaxine) treatment of these symptoms during the early withdrawal phase of alcohol compared to a group treated only with psychotherapy. A total of 60 alcohol-dependent/abusing subjects randomly assigned to three groups (psychotherapy, psychotherapy plus mirtazapine, psychotherapy plus venlafaxine) were studied. Assessment of psychopathology and global functioning throughout a 4-5-week detoxification period was done by the Hamilton Anxiety Rating Scale (HARS), the Hamilton Depression Rating Scale (HDRS), and the Global Assessment Scale (GAS). At baseline, high scores of anxiety and depression were recorded (HARS: controls: 33.1±7.8, mirtazapine: 33.2±12.6, venlafaxine: 36.6±5.4; HDRS: controls: 39.5±7.4, mirtazapine: 37.9±7.8, venlafaxine: 41.9±4.5). A marked improvement (p<0.000) was evidenced in all groups by the end of the detoxification period. However, patients on mirtazapine improved significantly more compared to the other two groups (HARS: controls: 9.6±7.6, mirtazapine: 4.3±4.4*, venlafaxine: 7.2±4.1, *p=0.011; HDRS: controls: 8.6±7.9, mirtazapine: 3.8±3.2*, venlafaxine: 8.2±3.5, *p=0.017; GAS: controls: 79.5±9.4, mirtazapine: 87.5±5.5**, venlafaxine: 83.0±8.0, **p=0.006). It is concluded that addition of mirtazapine, but not venlafaxine, to a standard psychotherapy-oriented alcohol detoxification treatment may facilitate the detoxification process by minimizing psychological discomfort. Consequently, it may prove to be a facilitator for the long-term abstinence from alcohol.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 1, January 2005, Pages 55-60
نویسندگان
, , , ,