کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9016327 | 1128089 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association between Ala-9Val polymorphism of Mn-SOD gene and schizophrenia
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کلمات کلیدی
dNTPdeoxy nucleotide triphosphateBPRSdGTPdCTPdATPDTTPALACATalanine - آلانینamyotrophic lateral sclerosis - اسکلروز جانبی آمیوتروفیکAIMS - اهدافALS - بیماری اسکلروز جانبی آمیوتروفیکCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیCu,Zn-SOD - مس، روی-SODBrief Psychiatric Rating Scale - مقیاس رتبه بندی روانپزشکی کوتاهAbnormal Involuntary Movement Scale - مقیاس غیر مجاز جنبش غیر مجازCatalase - کاتالاز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Association between Ala-9Val polymorphism of Mn-SOD gene and schizophrenia Association between Ala-9Val polymorphism of Mn-SOD gene and schizophrenia](/preview/png/9016327.png)
چکیده انگلیسی
Reactive oxygen species (ROS) have been suggested to play an important role in physiopathology of schizophrenia. The major intracellular antioxidant enzymes, copper-zinc superoxide dismutase in the cytoplasm and manganese superoxide dismutase (Mn-SOD) in the mitochondria, rapidly and specifically reduce superoxide radicals to hydrogen peroxide. Polymorphisms in the genes encoding antioxidant enzymes should therefore result in predisposition to schizophrenia. The present study was performed to assess whether there is a genetic association between a functional polymorphism (Ala-9Val) in the human Mn-SOD gene in schizophrenic patients (n=153) and healthy controls (n=196) using a PCR/RFLP method. Significant differences in the genotypic distribution between schizophrenics and controls were observed. Genotypic distribution with 14 (9.2%) Ala/Ala, 106 (69.3%) Ala/Val and 33 (21.6%) Val/Val subjects in schizophrenia was different from those of controls with 46 (23.5%), 83 (42.3%) and 67 (34.2%), respectively (p<0.0001). When the patients with schizophrenia were divided into the subgroups as disorganized, paranoid and residual, there was a significant difference in genotypic distribution among the subgroups (Ï2=11.35, df=4, p=0.023). This association between -9Ala Mn-SOD allele and schizophrenia suggests that -9Ala variant may have a contribution in the physiopathogenesis of schizophrenia. Further investigations are warranted in larger populations with other susceptible genes that might be associated with schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 1, January 2005, Pages 123-131
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 1, January 2005, Pages 123-131
نویسندگان
Omer Akyol, Medaim Yanik, Halit Elyas, Mustafa Namli, Halit Canatan, Haluk Akin, Huseyin Yuce, H. Ramazan Yilmaz, Hamdi Tutkun, Sadik Sogut, Hasan Herken, Hüseyin Ãzyurt, Haluk Asuman Savas, Suleyman Salih Zoroglu,