کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9016424 | 1128095 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Severe cognitive impairment correlates with higher cerebrospinal fluid levels of lactate and pyruvate in a canine model of senile dementia
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کلمات کلیدی
SCDMMSECognitive test - آزمون شناختیLCD - ال سی دیAlzheimer disease - بیماری آلزایمرCNS - دستگاه عصبی مرکزیANS - سالDog - سگcentral nervous system - سیستم عصبی مرکزیLactate - لاکتاتCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیEnergy metabolism - متابولیسم انرژیPotassium - پتاسیمPyruvate - پیروات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Diagnosis of dementia of the Alzheimer's type depends on clinical criteria and exclusion of other disorders because, at this time, a validated biological marker, aside from histological brain examination, remains to be established. The canine counterpart of senile dementia of the Alzheimer type (ccSDAT) is considered a promising model for examining behavioral, cellular and molecular processes involved in early phases of human brain aging and Alzheimer disease (AD). In order to investigate the first events taking place in canine cognitive dysfunction, in this paper we established a new and rapid behavioral test that finely discriminates the degrees of cognitive impairment. Cerebrospinal fluid (CSF) analysis was performed to determine the relationship between each disease stage and modification of cerebral energy metabolism. Our results demonstrate a parallel increase of lactate, pyruvate and potassium concentrations in the severe cognitive deficit. These differences are discussed in view of the neuroprotective role presently given to lactate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 4, May 2005, Pages 603-610
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 4, May 2005, Pages 603-610
نویسندگان
Marco Pugliese, Josep Lluis Carrasco, Carmen Andrade, Ernesto Mas, Joan Mascort, Nicole Mahy,