کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9028632 | 1561662 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Urinary t,t-muconic acid, S-phenylmercapturic acid and benzene as biomarkers of low benzene exposure
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Urinary t,t-muconic acid, S-phenylmercapturic acid and benzene as biomarkers of low benzene exposure Urinary t,t-muconic acid, S-phenylmercapturic acid and benzene as biomarkers of low benzene exposure](/preview/png/9028632.png)
چکیده انگلیسی
This research compared the capability of urinary trans,trans-muconic acid (t,t-MA), S-phenylmercapturic acid (S-PMA) and benzene excreted in urine (U-benzene) to monitor low benzene exposure and evaluated the influence of smoking habit on these indices. Gasoline attendants, urban policemen, bus drivers and two groups of referents working in two large Italian cities (415 people) were studied. Median benzene exposure was 61, 22, 21, 9 and 6 μg/m3, respectively, with higher levels in workers than in referents. U-benzene, but not t,t-MA and S-PMA, showed an exposure-related increase. All the biomarkers were strongly influenced by cigarette smoking, with values up to five-fold higher in smokers compared to non-smokers. In conclusion, in the range of investigated benzene exposure (<478 μg/m3 or <0.15 ppm), the smoking habit may be regarded as a major source of benzene intake; among the study indices, U-benzene is the marker of choice for the biological monitoring of occupational and environmental exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volumes 153â154, 30 May 2005, Pages 253-256
Journal: Chemico-Biological Interactions - Volumes 153â154, 30 May 2005, Pages 253-256
نویسندگان
Silvia Fustinoni, Marina Buratti, Laura Campo, Antonio Colombi, Dario Consonni, Angela C. Pesatori, Matteo Bonzini, Peter Farmer, Seymour Garte, Federico Valerio, Domenico F. Merlo, Pier A. Bertazzi,