کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9029477 | 1561661 | 2005 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Garlic oil and DDB, comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by glutathione deficiency in rats
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کلمات کلیدی
BSOUrsodesoxycholic acidDDBUDCAHAIALTGSHAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Liver injury - آسیب کبدیAlanine aminotransferase - آلانین آمینوترانسفرازHepatoprotective effect - اثر محافظتی محافظتیbuthionine sulfoximine - بوته یون سولفسیمیمGarlic oil - روغن سیرhistological activity index - شاخص فعالیت هیستولوژیکlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH Glutathione - گلوتاتیون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A pharmaceutical composition PENNEL® comprising garlic oil (GO) and dimethyl-4,4â²-dimethoxy-5,6,5â²,6â²-dimethylene dioxybiphenyl-2,2â²-dicarboxylate (DDB) as ingredients active for phase II enzyme induction and liver protection, respectively, has been used as a curative preparation for patients with acute or chronic viral hepatitis. In spite of the wide clinical use of PENNEL® in Asian and Middle Eastern countries, whether GOÂ +Â DDB treatment synergistically protects the liver from injuries potentiated by GSH deficiency compared to the individual treatment has not been determined. This study investigated the effects of GOÂ +Â DDB in comparison with each ingredient alone on chemical-induced liver injury potentiated by a GSH depleting agent. Rats that had been daily pretreated with GOÂ +Â DDB, GO, DDB, ursodesoxycholic acid or silymarin for 6 days were exposed to buthionine sulfoximine (BSO) and then injected with a single dose of CCl4. The effects of the agents on acute liver toxicities induced by BSO, CCl4 or BSOÂ +Â CCl4 were assessed by blood biochemistry and histopathology. GOÂ +Â DDB pretreatment effectively prevented increases in plasma aminotransferases or lactate dehydrogenase activities in rats exposed to BSOÂ +Â CCl4, compared to GO or DDB treatment alone. Whereas BSO potentiated CCl4-induced liver injuries as evidenced by elevations in central necrosis, hepatocyte degeneration and inflammation, pretreatment with GOÂ +Â DDB abrogated BSOÂ +Â CCl4-induced liver injuries more efficaciously than did that with GO or DDB. The hepatoprotective effect of GOÂ +Â DDB was superior to that of ursodesoxycholic acid or silymarin. Also, blood biochemistry indicated that GOÂ +Â DDB pretreatment prevented increases in plasma triglyceride contents in rats insulted with CCl4 or BSOÂ +Â CCl4. The present study demonstrated that GOÂ +Â DDB, when daily pretreated for six consecutive days, exerted synergistic protection of the liver from chemical-induced injury potentiated by the condition of GSH deficiency, and has additional advantages in lowering the plasma lipids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 155, Issues 1â2, 30 June 2005, Pages 82-96
Journal: Chemico-Biological Interactions - Volume 155, Issues 1â2, 30 June 2005, Pages 82-96
نویسندگان
Eun Young Park, Sung Hwan Ki, Myong Sok Ko, Choon Won Kim, Min Ho Lee, Young Sok Lee, Sang Geon Kim,