Differential effects of IFN-α on the expression of various TH2 cytokines in human CD4+ T cells

These results indicate that IFN-α enhances the induction of TH1 responses through upregulation of T-bet mRNA expression, as well as the induction of TH2 responses through upregulation of c-Maf mRNA expression, followed by IL-4 expression. Moreover, the data also suggest that IFN-α might suppress the expression of IL-5 and IL-13 in differentiated TH2 cells.