کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9225652 | 1201996 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of rhinovirus in asthma exacerbations
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کلمات کلیدی
IL-1RAURIICAMasthma exacerbations - آسم تشدید می شودIL-1 receptor antagonist - آنتاگونیست گیرنده IL-1Upper respiratory tract infection - عفونت دستگاه تنفسی فوقانیgranulocyte colony-stimulating factor - فاکتور تحریک کننده کلنی گرانولوسیتG-CSF - فاکتور محرک کُلونی گرانولوسیتintercellular adhesion molecule - مولکول چسبندگی بین سلولیRhinovirus - ویروس سرماخوردگی انسانی، راینو ویروسvirology - ویروس شناسی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Rhinoviruses are a major cause of asthma exacerbations in children and adults. With the use of sensitive RT-PCR methods, respiratory viruses are found in approximately 80% of wheezing episodes in children and in approximately one half of such episodes in adults. Rhinovirus is a member of the family Picornaviridae, and acute rhinovirus infections occur predominantly in the upper airway. This virus has also been identified in the lower airway, and it might cause acute wheezing through the production of proinflammatory mediators with a resulting neutrophilic inflammatory response. Precisely how this process leads to increases in airway hyperresponsiveness and airway obstruction is not fully established. However, risk factors for wheezing with colds include asthma and atopy, extremes in age, and perhaps having a deficient TH1 response to rhinovirus. With the use of in vitro models and experimental inoculation studies, significant advances have led to a better understanding of the mechanisms by which rhinovirus infections cause asthma exacerbations. Advances in our understanding of this interaction might provide knowledge that could ultimately lead to specific treatment modalities to prevent and/or treat this significant burden of asthma exacerbations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 116, Issue 2, August 2005, Pages 267-273
Journal: Journal of Allergy and Clinical Immunology - Volume 116, Issue 2, August 2005, Pages 267-273
نویسندگان
Samuel L. MD, William W. MD,