Interactions of 1α,25-dihydroxyvitamin D3 with IL-12 and IL-4 on cytokine expression of human T lymphocytes

Our data imply that the specific actions of 1α,25(OH)2D3 on cytokine-stimulated T-cell functions could play a role in the prevention of TH/TC1-related autoimmune diseases but also predispose toward TH/TC2-mediated allergic reactions.