The concepts of the new criteria for Yusho poisoning

Three criteria are proposed based on different approaches: 2,3,4,7,8-PeCDF level adjusted for age and sex (criterion 1), its one-tailed upper prediction limit (criterion 2), and the estimated probability of being a Yusho patient (criterion 3). By applying these three criteria to potential victims who had not been diagnosed as having Yusho according to the current diagnostic criteria, the same people were identified as Yusho sufferers. Criterion 1 with an upper 99 percentile of age- and sex-adjusted 2,3,4,7,8-PeCDF level of controls as a cut-off was determined, from a practical perspective, to be superior to the other criteria.