کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9262888 | 1215811 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ligand recognition by antigen-presenting cell C-type lectin receptors
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کلمات کلیدی
CLRITAMMHC-IBDCAICAMMHC-IIPRRTLRAPCCRDFibronectin type IIMHC class I - MHC کلاس IMHC class II - MHC کلاس IIantigen-presenting cell - آنتیژن ارائه سلولToll-like receptor - تیالآرcarbohydrate recognition domain - دامنه شناخت کربوهیدراتDendritic cell - سلول دندریتیکMacrophage - ماکروفاژ intercellular adhesion molecule - مولکول چسبندگی بین سلولیMø - وزارت معارفpattern recognition receptor - گیرنده شناسایی الگوC-type lectin receptor - گیرنده لکتین نوع CMannose receptor - گیرنده مانوز
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
It is now appreciated that the range of ligands interacting with C-type lectin type receptors on antigen presenting cells includes endogenous self-molecules as well as pathogens and pathogen-derived ligands. Interestingly, not all interactions between these receptors and pathogenic ligands have beneficial outcomes, and it appears that some pathogens have evolved immunoevasive or immunosuppressive activities through receptors such as DC-SIGN. In addition to this, recent data indicate that the well-characterised macrophage mannose receptor is not essential to host defence against fungal pathogens, as previously thought, but has an important role in regulating endogenous glycoprotein clearance. New studies have also demonstrated that different ligand binding and/or sensing receptors collaborate for full and effective immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 17, Issue 1, February 2005, Pages 18-24
Journal: Current Opinion in Immunology - Volume 17, Issue 1, February 2005, Pages 18-24
نویسندگان
Eamon P McGreal, Joanna L Miller, Siamon Gordon,