کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9262898 | 1215811 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antigen presentation and recognition in bacterial infections
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کلمات کلیدی
TCrAPCPIMTLRListeriolysinphosphatidyl-myo-inositol mannosideantigen-presenting cell - آنتیژن ارائه سلولLTP - تقویت طولانی مدت یا LTP Toll-like receptor - تیالآرDendritic cell - سلول دندریتیکendoplasmic reticulum - شبکه آندوپلاسمی Hly - هلیlipid transfer protein - پروتئین انتقال لیپیدT-cell receptor - گیرنده لنفوسیت T
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Antigen processing and recognition is a key feature of antibacterial immune responses to intracellular bacteria. In contrast to viruses, which are primarily controlled by conventional MHC II- and MHC I-restricted CD4+ or CD8+ T cells, respectively, unconventional T cells participate additionally in antibacterial protection. These unconventional T cells include glycolipid-specific CD1-restricted T cells and phospholigand-specific γδ T cells. We are just beginning to understand the broad spectrum of antigen recognition and stimulation of distinct T-cell populations by bacterial pathogens. From the host perspective, a broad spectrum of different T-cell populations that recognize proteins, lipids and carbohydrates strengthens protective immunity. From the perspective of the pathogen, antigen presentation represents a bottleneck that should be exploited for evasion from, or devastation of, acquired immunity. Although several such mechanisms have been described in viral systems, few have thus far been elucidated in bacterial infections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 17, Issue 1, February 2005, Pages 79-87
Journal: Current Opinion in Immunology - Volume 17, Issue 1, February 2005, Pages 79-87
نویسندگان
Stefan HE Kaufmann, Ulrich E Schaible,