کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9266313 | 1217278 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tumor necrosis factor-alpha promoter polymorphism in Mexican patients with Chagas' disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study was to investigate whether the promoter's polymorphisms at the TNF alpha (TNF-α) gene were associated with the genetic susceptibility to Chagas' disease. We analyzed the TNF-α (positions â308, and â238) polymorphisms in a sample of 54 serologically positive chagasic individuals and in 169 healthy controls. The patients were divided according to clinical characteristics as asymptomatics (n = 27), and chronic chagasic cardiopathy (CCC) patients (n = 27). The whole group of patients showed increased frequencies of â308 T2 (A) allele when compared to healthy controls (pC = 0.008, OR = 3.03). When the analysis was carried out separately in asymptomatic and CCC patients, increased frequencies of T2 (A) allele and T1T2 (AG) genotype in the group of patients with CCC were found when compared to asymptomatic individuals (pC = 0.0002 and pC = 0.003, respectively) and healthy controls (pC = 4 Ã 10â7, OR = 7.02, and pC = 0.0006, OR = 5.29, respectively). The present study demonstrates that Chagas' disease is associated with TNF-α polymorphisms in the Mexican population. The TNF-308 T2 allele could be directly involved in the genetic susceptibility to the chronic phase of the disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 98, Issue 1, 15 April 2005, Pages 97-102
Journal: Immunology Letters - Volume 98, Issue 1, 15 April 2005, Pages 97-102
نویسندگان
José Manuel RodrÃguez-Pérez, David Cruz-Robles, Guadalupe Hernández-Pacheco, Nonanzit Pérez-Hernández, Luis Enrique MurguÃa, Julio Granados, Pedro Antonio Reyes, Gilberto Vargas-Alarcón,