کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9893158 | 1541489 | 2005 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Is there a role for copper in neurodegenerative diseases?
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کلمات کلیدی
COXCuBDCTR1PrPcCJDAPPROS - ROSamyotrophic lateral sclerosis - اسکلروز جانبی آمیوتروفیکAlzheimer disease - بیماری آلزایمرALS - بیماری اسکلروز جانبی آمیوتروفیکSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازcytochrome c oxidase - سیتوکروم سی اکسیدازCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیCopper - مسCopper homeostasis - هومئوستاز مسPrion protein - پروتئین پریونAmyloid-precursor protein - پروتئین پیش ماده آمیلئیدcellular prion protein - پروتون پریون سلولیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Copper is an essential metal in living organisms; thus, the maintenance of adequate copper levels is of vital importance and is highly regulated. Dysfunction of copper metabolism leading to its excess or deficiency results in severe ailments. Two examples of illnesses related to alterations in copper metabolism are Menkes and Wilson diseases. Several proteins are involved in the maintenance of copper homeostasis, including copper transporters and metal chaperones. In the last several years, the β-amyloid-precursor protein (β-APP) and the prion protein (PrPC), which are related to the neurodegenerative disorders Alzheimer and prion diseases respectively, have been associated with copper metabolism. Both proteins bind copper through copper-binding domains that also have been shown to reduce copper in vitro. Moreover, this ability to reduce copper is associated with a neuroprotective effect exerted by the copper-binding domain of both proteins against copper in vivo. In addition to a functional link between copper and β-APP or PrPC, evidence suggests that copper has a role in Alzheimer and prion diseases. Here, we review the evidence that supports both, the role of β-APP and PrPC, in copper metabolism and the putative role of copper in neurodegenerative diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Aspects of Medicine - Volume 26, Issues 4â5, AugustâOctober 2005, Pages 405-420
Journal: Molecular Aspects of Medicine - Volume 26, Issues 4â5, AugustâOctober 2005, Pages 405-420
نویسندگان
Waldo Cerpa, Lorena Varela-Nallar, Ariel E. Reyes, Alicia N. Minniti, Nibaldo C. Inestrosa,