کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918838 | 1557560 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Absorption-enhancing effect of glycyrrhizin induced in the presence of capric acid
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کلمات کلیدی
TEERdipotassium glycyrrhizinateFD-4PKCIP3HBSSScT - ScT درEDTA - اتیلن دی آمین تترا استیک اسید Sodium caprate - اسید سدیمColon delivery - تحویل کولونAbsorption enhancer - تقویت جذبCaco-2 cell - سلول Caco-2Sodium fluorescein - فلورسین سدیمHanks’ balanced salt solution - محلول نمک متعادل هانکسtransepithelial electrical resistance - مقاومت الکتریکی transepithelialProtein kinase C - پروتئین کیناز سیSalmon calcitonin - کالسیتورین ماهی قزل آلاGlycyrrhizin - گلیسیریزین
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Absorption-enhancing effect of glycyrrhizin induced in the presence of capric acid Absorption-enhancing effect of glycyrrhizin induced in the presence of capric acid](/preview/png/9918838.png)
چکیده انگلیسی
The absorption-enhancing effect of the simultaneous administration of sodium caprate (Cap-Na) and dipotassium glycyrrhizinate (Grz-K) was investigated to clarify an effect of Grz-K. A combination of 0.1% (w/v) Cap-Na and 2% (w/v) Grz-K had a rapid and long-lasting absorption-enhancing activity in Caco-2 cell monolayers under conditions where Cap-Na and Grz-K showed a weak and no activity, respectively. The simultaneous treatment of a Caco-2 cell monolayer with Cap-Na and Grz-K showed no change in intracellular calcium ion level, although a major mechanism of absorption-enhancing effect for Cap-Na was elevation of intracellular calcium ion level. On the other hand, the simultaneous enhancing effect of Cap-Na and Grz-K was inhibited by H7, a PKC inhibitor. Possibly, Grz-K showed an absorption-enhancing effect via PKC cellular signaling pathway after penetration into cell according to increasing membrane permeability by Cap-Na. The absorption of sCT by the rat colon was enhanced by a combination of 0.1% (w/v) Cap-Na and 2% (w/v) Grz-K, and its effect continued even 9Â h after the onset of the experiment. Furthermore, the simultaneous treatment of 0.1% (w/v) Cap-Na and 2% (w/v) Grz-K showed a negligible histological changes to the colon mucosal membrane and a negligible toxicity on Caco-2 cell monolayer. A combination of Cap-Na and Grz-K shows a synergistic absorption-enhancing effect with little mucosal injury, which is applicable to colon-specific delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 294, Issues 1â2, 27 April 2005, Pages 11-21
Journal: International Journal of Pharmaceutics - Volume 294, Issues 1â2, 27 April 2005, Pages 11-21
نویسندگان
Teruko Imai, Michinori Sakai, Hiroshi Ohtake, Hidekazu Azuma, Masaki Otagiri,