Activation of the AMP-Activated Protein Kinase Reduces Inflammatory Nociception
Keywords: AMPK; AICAR; metformin; inflammation; pain behavior; spinal cord;
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Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: Potential therapeutic targets for cardiac cachexia
Keywords: Ang II; angiotensin II; AT1R; angiotensin II type 1 receptor; CHF; congestive heart failure; ESRD; end-stage renal disease; ACE; angiotensin-converting enzyme; UPS; ubiquitin proteasome system; ROS; reactive oxygen species; IGF-1; insulin-like growth fact
Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes
Keywords: AICAR; 5-amino-4-imidazole-carboxamideriboside; ACC; acetyl-CoA carboxylase; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; CRP; C-reactive protein; HP; haptoglobin; IKK; IkappaB kinase; IL-6; Interleukin-6; IL6Rα; IL-6 receptor subun
Inhibition of platelet-derived growth factor receptor tyrosine kinase and downstream signaling pathways by Compound C
Keywords: AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; AMPK; AMP-activated protein kinase; BS3; bis-sulfosuccinimidyl suberate; Cdk; cyclin-dependent protein kinases; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ERK; extrace
AMP-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in Duchenne muscular dystrophy
Keywords: AMPK; autophagy; fiber type; AICAR; utrophin A; DMD
The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells
Keywords: Leukaemia; PTEN; mTOR; AMPK; Metformin; AICAR
Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism
Keywords: ACh; acetylcholine; AICAR; aminoimidazole carboxamide ribonucleotide; AMPK; adenosine monophosphate protein kinase; COX; cyclooxygenase; CVD; cardiovascular disease; EDD; endothelium dependent dilation; EDHF; endothelial derived hyperpolarizing factor; l-
AMP-activated protein kinase stimulates myostatin expression in C2C12 cells
Keywords: AMPK; Myostatin; AICAR; Metformin; C2C12 cells
(â)-Epigallocatechin-3-gallate stimulates both AMP-activated protein kinase and nuclear factor-kappa B signaling pathways
Keywords: EGCG; (â)-epigallocatechin-3-gallate; SHARP; enhancer of split- and hairy-related protein; PEPCK; phosphoenolpyruvate carboxykinase; PI 3-K; phosphoinositide 3-kinase; aPKCλ; atypical protein kinase C lambda; AMPK; AMP-activated protein kinase; NF-κB;
Glucocorticoids reduce inflammation in cystic fibrosis bronchial epithelial cells
Keywords: Aicar; 5-aminoimidazole-4-carboxamide-1-d-ribonucleoside; AMPK; AMP-activated protein kinase; AP-1; activator protein-1; CF; cystic fibrosis; CFTR; cystic fibrosis transmembrane conductance regulator; COPD; chronic obstructive pulmonary disease; CXCR; che
AMP-activated kinase relaxes agonist induced contractions in the mouse aorta via effects on PKC signaling and inhibits NO-induced relaxation
Keywords: AICAR; AMPK; Mouse; PKC; NO; SNP
Coenzyme Q10 increases the fatty acid oxidation through AMPK-mediated PPARα induction in 3T3-L1 preadipocytes
Keywords: ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxy-amide-1-D-ribofuranoside; AMPK; AMP-activated protein kinase; CaMKK; Ca2 +/calmodulin-dependent protein kinase kinase; CoQ10; coenzyme Q10; PPARα; peroxisome proliferator-activated receptor
Dancing with the sterols: Critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis
Keywords: ABC; ATP Binding Cassette; AICAR; Aminoimidazole Carboxamide Ribonucleotide; ApoE; Apolipoprotein E; ApoER2; ApoE receptor 2 (LRP8); AR; Androgen Receptor; BAC; Bacterial Artificial Chromosome; CETP; Cholesterol Ester Transfer Protein; eNOS; endothelial N
Antiproliferative activity of levobupivacaine and aminoimidazole carboxamide ribonucleotide on human cancer cells of variable bioenergetic profile
Keywords: ADP; adenosine diphosphate; AICAR; 5-amino-4-imidazolecarboxamide ribonucleoside; ANT; adenine nucleoide translocator; ATP; adenosine triphosphate; COX; cytochrome c oxidase; Cyt c; cytochrome c; CoQ; coenzyme Q; OXPHOS; Oxidative Phosphorylation; RCR; re
Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
Keywords: 7-KC; 7-ketocholesterol; AAA; abdominal aortic aneurysm; AICAR; 5â²-aminoimidazole-4-carboxamide ribonucleoside; AMPK; adenosine monophosphate-activated protein kinase; AngII; angiotensin II; ApoE; apolipoprotein E; BH4; 5,6,7,8-tetrahydrobiopterin; CaMK
Potent vasodilation effect of amurensin G is mediated through the phosphorylation of endothelial nitric oxide synthase
Keywords: ACC; acetyl-CoA carboxylase; ACh; acetylcholine; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; AMPK; adenosine 5â²-monophosphate-activated protein kinase; CA-AMPK; constitutive active AMPK; CaMK II; calmodulin-dependent protein kinase II;
Adiponectin promotes hyaluronan synthesis along with increases in hyaluronan synthase 2 transcripts through an AMP-activated protein kinase/peroxisome proliferator-activated receptor-α-dependent pathway in human dermal fibroblasts
Keywords: HAS2; hyaluronan synthase 2; AMPK; AMP-activated protein kinase; AICAR; 5-aminoimidazole-4-carboxamide-1β-ribofuranoside; PPARα; peroxisome proliferator-activated receptor-α; AdipoR; adiponectin receptor; FBS; fetal bovine serum; MEM; modified Eagle'
Central AMP-activated protein kinase affects sympathetic nerve activity in rats
Keywords: Sympathetic nerve; Kidney; Hypothalamus; AICAR; Compound C; Adrenal gland;
AICAR response element binding protein (AREBP), a key modulator of hepatic glucose production regulated by AMPK in vivo
Keywords: AICAR; 5-aminoimidzole-4-carboxamide-1-β-d-ribofuranoside; AMPK; AMP-activated protein kinase; AREBP; AICAR response element binding protein; GLUT4; glucose transporter 4; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenolpyruvate carboxykinase; AREBP; AI
AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats
Keywords: AMPK; AMP-activated protein kinase; AICAR; 5-aminoimidazole-4-carboxamide-1β-riboside; ARC; arcuate nucleus; HKRB; HEPES-buffered Krebs-Ringer bicarbonate buffer; NPY; neuropeptide Y; POMC; proopiomelanocortin; SD; Sprague-Dawley; AMPK; AICAR; NPY; POM
AICAR induced AMPK activation potentiates neuronal insulin signaling and glucose uptake
Keywords: AMPK, AMP activated protein kinase; AICAR, 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; GSK-3β, glycogen synthase kinase-3β; AD, Alzheimer ’s disease; Aβ, β-amyloidNeuronal insulin signaling; AMPK; AICAR; Glucose uptake
AMP-activated protein kinase attenuates Wnt/β-catenin signaling in human osteoblastic Saos-2 cells
Keywords: AMPK; AMP-activated protein kinase; TCF; T-cell transcription factor; LiCl; lithium chloride; LRP; low-density lipoprotein receptor-related protein; APC; adenomatous polyposis coli; axin; axis inhibitor; CK1; casein kinase 1; GSK3β; glycogen synthase kin
AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells
Keywords: AMP-activated protein kinase (AMPK); Metformin; AICAR; Dlx5; Runx2; Osteoblast differentiation
Accelerated cellular senescence phenotype of GAPDH-depleted human lung carcinoma cells
Keywords: AICAR; 5-aminoimidazole-4-carboxyamide ribonucleoside; Compound C; 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine; DAPI; 4â²,6â²-diamidino-2-phenylindole; 2DG; 2-deoxyglucose; DSB; double strand breaks; pGAPDH; GAPDH-expres
Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo
Keywords: AICAR; 5-aminoimidazole-4-carboxamide 1-β-d-furanoside; AMPK; adenosine monophosphate-activated protein kinase; HUVEC; human umbilical vein endothelial cells; NF-κB; nuclear factor kappa-B; PI3K; phopsphatidyl inositol-3kinase; iNOS; inducible nitric ox
Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients
Keywords: T2D; type 2 diabetes; IMCL; intramuscular lipid; ACC; acetyl-CoA carboxylase; AMPK; AMP activated protein kinase; AICAR; AMP-mimetic 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; FA; fatty-acid; ASM; acid-soluble metabolites; CS; citrate synthase;
14-3-3 proteins in neurodegeneration
Keywords: TH; tyrosine hydroxylase; 3â²UTR; three prime untranslated region; CSF; cerebrospinal fluid; 2D-PAGE; two-dimensional polyacrylamide gel electrophoresis; PD; Parkinson disease; AD; Alzheimer disease; CJD; Creutzfeldt-Jakob disease; MSA; multiple system a
5-Aminoimidazole-4-Carboxamide Riboside Enhances Effect of Ionizing Radiation in PC3 Prostate Cancer Cells
Keywords: 5-aminoimidazole-4-carboxamide riboside; AICAR; Radiosensitization; Prostate cancer; Adenosine monophosphate-activated protein kinase; In vitro;
Supplementation of pyruvate prevents palmitate-induced impairment of glucose uptake in C2 myotubes
Keywords: AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; AMPK; AMP-activated protein kinase; BCH; 2-aminobicyclo[2.2.1]heptan-2-carboxylic acid; CPT-1; carnitine palmitoyl transferase-1; FFA; free fatty acid; FAO; fatty acid oxidation; GLUT4; glucose
Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death
Keywords: 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; ACC; acetyl-CoA carboxylase; AD; Alzheimer disease; AICAR; 5-amino-4-imidazolecarboxamide ribose; Akt; protein kinase B; AMPK; AMP-activated kinase; CM-H2DCFDA; 5-(and-6)-chloromethyl-2â²,7â²-di
Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)
Keywords: ASL; adenylosuccinate lyase; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; ZMP; 5-aminoimidazole-4-carboxamide ribonucleotide; Plasmodium falciparum; AICAR; ZMP; Adenylosuccinate lyase; Purine salvage pathway; Anti-malarial;
Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass
Keywords: 4E-BP1; 4E binding protein 1; 5â²UTR; 5â² untranslated region; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMP; adenosine monophosphate; AMPK; 5â²-AMP-activated protein kinase; AMPK α1â/â; AMPK α1 subunit knockout; AMPKα1â/âα2â/â; A
AICAR and Compound C regulate food intake independently of AMP-activated protein kinase in lines of chickens selected for high or low body weight
Keywords: AICAR; AMPK; Chick; Compound C; Food intake
Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain
Keywords: AMP; adenosine 5â²-monophosphate; IMP; inosine 5â²-monophosphate; IMPDH; inosine monophosphate dehydrogenase; NAD; nicotinamide adenine dinucleotide; NMN; nicotinamide mononucleotide; TR; tiazofurin; TAD; thiazole-4-carboxamide adenine dinucleotide; MPA
Energy metabolism in adult neural stem cell fate
Keywords: ACC; adenylate cyclase complex; AICAR; aminoimidazole carboxamide ribonucleotide; AMPK; AMP-activated protein kinase; Aspm; abnormal spindle-like microcephaly-associated; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; bHLH;
AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival
Keywords: AICAR; 5-aminoimidazole-4-carboxamide riboside; AMPK; AMP-activated kinase; mTOR; mammalian target of rapamycin; PI3-K; phosphatidylinositol 3-kinase; AMP-activated kinase (AMPK); Malignant melanoma; 5-Aminoimidazole-4-carboxamide riboside (AICAR); Metfor
Metabolic preconditioning of cells with AICAR-riboside: Improved cryopreservation and cell-type specific impacts on energetics and proliferation
Keywords: AICAR; Adenylate levels; ATP; Metabolism; Cell stasis; Biostabilization
The 5′ adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics
Keywords: AICAR; AMPK; Exercise; Fatty acids; GLUT-4; Glycogen; Muscle
Leptin inhibits glycogen synthase kinase-3β to prevent tau phosphorylation in neuronal cells
Keywords: Leptin; AICAR; GSK-3β; Tau; Alzheimer's disease
AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase
Keywords: Fatty Acid Synthase; AMPK; Cancer; Hepatitis C; Obesity; Diabetes; AICAR
2-Deoxy-d-glucose protects neural progenitor cells against oxidative stress through the activation of AMP-activated protein kinase
Keywords: 2DG; AMP-activated protein kinase; Neural stem cell; Oxidative stress; AICAR;
Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells
Keywords: Alzheimer’s disease; Leptin; AICAR; β-Amyloid; Tau; AMPK; GSK-3β; PPARγ
Adenosine monophosphate-activated protein kinase inhibits cardiac hypertrophy through reactivating peroxisome proliferator-activated receptor-α signaling pathway
Keywords: Cardiac hypertrophy; AICAR; AMPK; PPARα; Fatty acid oxidation
Activación de PP2A y alteraciones metabólicas inducidas por la ingestión de fructosa en forma líquida
Keywords: Leptina; Fructosa; AMPK; AICAR; PP2A; FoxO1Leptin; Fructose; AMPK; AICAR; PP2A; FoxO1
Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1
Keywords: ACC; acetyl-CoA carboxylase; ADRP; adipose differentiation-related protein; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; AMPK; AMP-activated protein kinase; ApoB; apolipoprotein B; FAS; fatty acid synthase; GAPDH; glyceraldehyde-3-phosphate dehyd
Protection of Epithelial Barrier Function by the Crohn's Disease Associated Gene Protein Tyrosine Phosphatase N2
Keywords: AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribonucleoside; AMPK; adenosine monophosphate-activated protein kinase; CC; compound C; CD; Crohn's disease; FITC; fluorescein isothiocyanate; IBD; inflammatory bowel disease; IEC; intestinal epithelial cells;
Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons
Keywords: AMPK; NPY; Ghrelin; ACC; Ca2+; AICAR; Compound C; Feeding; Arcuate nucleus
Role of AMP-activated protein kinase in autophagy and proteasome function
Keywords: AICAR; AMPK; Proteasome; PI3-kinase; Protein degradation; Autophagy
Potential role of lipin-1 in exercise-induced mitochondrial biogenesis
Keywords: Lipin-1; Exercise; Skeletal muscle; Mitochondria; Rat; AMP-activated protein kinase; β2-adrenergic receptor; AICAR; Clenbuterol