دانلود مقالات ISI درباره بیماری آلزایمر + ترجمه فارسی

Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade

Keywords: بیماری آلزایمر; AChE; acetylcholinesterase; AD; Alzheimer's disease; B12H; bis(12)-hupyridone; CGNs; cerebellar granule neurons; DHβE; dihydro-β-erythroidine; GSK3β; glycogen synthase kinase 3β; mAChR; muscarinic acetylcholine receptor; MLA; methyllycaconitine; NMD

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

The thiol proteinase inhibitor E-64-d ameliorates amyloid-β-induced reduction of sAPPα secretion by reversing ceramide-induced protein kinase C down-regulation in SH-SY5Y neuroblastoma cells

Keywords: بیماری آلزایمر; Alzheimer's disease; Amyloid precursor protein; Calpain; Ceramide; Protein kinase C;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Formation of non-toxic Aβ fibrils by small heat shock protein under heat-stress conditions

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; SPs; senile plaques; NFTs; neurofibrillary tangles; CAA; cerebrovascular amyloid angiopathy; Aβ; amyloid-β peptides; sHsp; small heat shock protein; SpHsp16.0; sHsp from fission yeast Schizosaccharomyces pombe; Amyloid-β; Amy

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; Oxadiazepine; Amyloid precursor protein; Gamma secretase modulator; hERG;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Fibrillar seeds alleviate amyloid-β cytotoxicity by omitting formation of higher-molecular-weight oligomers

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Aβ; β-amyloid; ITC; isothermal titration calorimetry; SEC; size exclusion chromatography; PBS; phosphate buffered saline; ThT; Thioflavin T; MTT; 3-(4,5-dimethyl-2-thiazoyl)-2,5-diphenyltetrazoliumbromide; SDS-PAGE; sodium dod

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Two β-strands of RAGE participate in the recognition and transport of amyloid-β peptide across the blood brain barrier

Keywords: بیماری آلزایمر; RAGE; Aβ; Alzheimer's disease; β-Strand;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Metabolic profile and biological activities of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco: Studies on the essential oil and polar extracts

Keywords: بیماری آلزایمر; Aβ; amyloid beta; AAPH; 2,2′-azobis(2-methylpropionamidine) dihydrochloride; ABTS+; 2,2′-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) radical cation; ACh; acetylcholine; AChE; acetylcholinesterase; AD; Alzheimer's disease; ATCI; acetylthiochol

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis, molecular modeling and evaluation of novel N′-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aβ aggregation

Keywords: بیماری آلزایمر; Alzheimer's disease; Cholinesterase; Beta-amyloid fibril; N-Acylhydrazone; Molecular modeling;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Accumulation of phenolic compounds in in vitro cultures and wild plants of Lavandula viridis L'Hér and their antioxidant and anti-cholinesterase potential

Keywords: بیماری آلزایمر; Aβ; amyloid beta; AAPH; 2,2′-azobis(2-methylpropionamidine) dihydrochloride; ABTS+; 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation; ACh; acetylcholine; AChE; acetylcholinesterase; AD; Alzheimer's disease; ATCI; acetylthiocholi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Brain expression level and activity of HDAC6 protein in neurodegenerative dementia

Keywords: بیماری آلزایمر; Alzheimer's disease; Deacetylase; Dementia with Lewy bodies; Frontotemporal lobar degeneration; HDAC6; Multiple system atrophy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Featured ArticleProgression of Alzheimer's disease as measured by Clinical Dementia Rating Sum of Boxes scores

Keywords: بیماری آلزایمر; Alzheimer's disease; Assessment of dementia; Clinical Dementia Rating; Clinical Dementia Rating Sum of Boxes; Cohort studies;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Featured ArticlePutting the Alzheimer's cognitive test to the test I: Traditional psychometric methods

Keywords: بیماری آلزایمر; Alzheimer's disease; Clinical trials; Psychometrics; Reliability; Validity;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Proteomic profiling of brain cortex tissues in a Tau transgenic mouse model of Alzheimer's disease

Keywords: بیماری آلزایمر; 2-DE; 2-dimensional gel electrophoresis; AD; Alzheimer's disease; ANOVA; analysis of variance; CSF; cerebrospinal fluid; ESI-Q-TOF MS/MS; electrospray ionization quadruple time-of-flight mass spectrometry; IEF; isoelectric focusing; KFDA; Korea Food & D

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Featured ArticleThe influence of insulin infusion on the metabolism of amyloid β peptides in plasma

Keywords: بیماری آلزایمر; Alzheimer's disease; Diabetes mellitus; Insulin; Amyloid β; Insulin degrading enzyme;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Aβ; amyloid-beta peptide; ThT; thioflavin T; PFE; methanol extract of Psoraleae Fructus; BKC; bakuchiol; PLD; psoralidin; BCN; bavachinin; IBC; isobavachalcone; NBIF; neobavaisoflavone; BC; bavachin; IPL; isopsoralen; PL; psora

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Featured Articleβ-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau

Keywords: بیماری آلزایمر; Alzheimer's disease; Dementia; Biomarker; Amyloid cascade; β-secretase;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates

Keywords: بیماری آلزایمر; Alzheimer's disease; Beta-secretase; BACE-1 inhibitor;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Neuroserpin up-regulation in the Alzheimer's disease brain is associated with elevated thyroid hormone receptor-β1 and HuD expression

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Aβ; amyloid-beta protein; NS; neuroserpin; THRβ1; thyroid hormone receptor-beta 1; HuD; Hu protein D; APP; amyloid precursor protein; Alzheimer's disease; Neuroserpin; Thyroid hormone receptor-β1; Tissue plasminogen activat

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity

Keywords: بیماری آلزایمر; Conformational constraint; Alzheimer's disease; BACE1 inhibitor; Macrocycle; β-Secretase;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Silencing of the P2X7 receptor enhances amyloid-β phagocytosis by microglia

Keywords: بیماری آلزایمر; Alzheimer's disease; Amyloid-β peptides; Microglia; P2X7 receptor; RNA interference;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for β-amyloid plaques

Keywords: بیماری آلزایمر; Alzheimer's disease; β-Amyloid plaque; PET; Autoradiography; Phenylindole;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides

Keywords: بیماری آلزایمر; BACE-1; Inhibitor; Alzheimer's disease; Structure based design; Cyclic sulfoxide hydroxyethylamine inhibitors; In vivo reduction of amyloid β-peptides;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Non-Gaussian diffusion MRI assessment of brain microstructure in mild cognitive impairment and Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; Mild cognitive impairment; MRI; Diffusion; Kurtosis; DKI;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators

Keywords: بیماری آلزایمر; Alzheimer's disease; γ-Secretase modulators;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Baroreflex function is reduced in Alzheimer's disease: a candidate biomarker?

Keywords: بیماری آلزایمر; Baroreflex; Alzheimer's disease; Diagnostics; Dementia; Mild cognitive impairment; Autonomic nervous system; Causal model;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

SO2 inhalation causes synaptic injury in rat hippocampus via its derivatives in vivo

Keywords: بیماری آلزایمر; SO2; Developing hippocampal neurons; Synaptic plasticity; Ischemic injury; Cognitive impairment; SO2; sulfur dioxide; SYP; synaptophysin; SV; synaptic vesicle; AD; Alzheimer's disease; PSD; postsynaptic densities; ERK; extracellular signal-regulated pro

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Substitution of membrane cholesterol with β-sitosterol promotes nonamyloidogenic cleavage of endogenous amyloid precursor protein

Keywords: بیماری آلزایمر; Aβ; beta amyloid; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE-1; β-secretase-1; BS; β-sitosterol; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; DMEM; Dulbecco's Minimum Essential Medium; ELISA; enzyme-linked im

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation

Keywords: بیماری آلزایمر; proNGF; Sortilin; Alzheimer's disease; Amyloid β; Tau; Choline acetyltransferase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Tartary buckwheat improves cognition and memory function in an in vivo amyloid-β-induced Alzheimer model

Keywords: بیماری آلزایمر; Amyloid beta; Alzheimer's disease; Buckwheat; Memory; Oxidative stress;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Cerebrospinal fluid Aβ42 is the best predictor of clinical progression in patients with subjective complaints

Keywords: بیماری آلزایمر; Subjective complaints; Biomarkers; Cerebrospinal fluid; Alzheimer's disease; Clinical progression; Predictive value;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia

Keywords: بیماری آلزایمر; Primary progressive aphasia; Logopenic variant of primary progressive aphasia; Alzheimer's disease; Neurofibrillary tangles; Hippocampus; MRI; Apolipoprotein E; TDP-43; Voxel-based morphometry; Alzheimer's dementia;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of function

Keywords: بیماری آلزایمر; TDP-43; trans-activation region DNA-binding protein of 43-kDa; RRM; RNA recognition motif; ALS; amyotrophic lateral sclerosis; FTLD; frontotemporal lobar degeneration; AD; Alzheimer's disease; PD; Parkinson's disease; HD; Huntington's disease; NTD;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Knockout of Toll-like receptor 2 attenuates Aβ25-35-induced neurotoxicity in organotypic hippocampal slice cultures

Keywords: بیماری آلزایمر; TLR2; Toll-like receptor 2; TLR2-KO; Toll-like receptor 2-knockout; WT; wild-type; PI; propidium iodide; AD; Alzheimer's disease; Aβ; amyloid beta peptide; OHSCs; organotypic hippocampal slice cultures; Toll-like receptor 2 (TLR2); Aβ25-35-induced n

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Protective effects of EphB2 on Aβ1-42 oligomer-induced neurotoxicity and synaptic NMDA receptor signaling in hippocampal neurons

Keywords: بیماری آلزایمر; Aβ; amyloid-β; AD; Alzheimer's disease; CREB; cAMP response element binding protein; DIV; days in vitro; FBS; fetal bovine serum; hAPP; human amyloid precursor protein; LDH; lactate dehydrogenase; LTP; long-term potentiation; MAPK; mitogen-activated p

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

The basic structural motif and major biophysical properties of Amyloid-β are encoded in the fragment 18-35

Keywords: بیماری آلزایمر; Alzheimer's disease; Protein aggregation; Solid-state NMR; Fluorescence correlation spectroscopy;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Structural and vibrational study of 8-hydroxyquinoline-2-carboxaldehyde isonicotinoyl hydrazone - A potential metal-protein attenuating compound (MPAC) for the treatment of Alzheimer's disease

Keywords: بیماری آلزایمر; Vibrational spectroscopy; XRD; DFT calculations; Alzheimer's disease; Isoniazid;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Interaction of glycine zipper fragments of Aβ-peptides with neuronal nitric oxide synthase: Kinetic, thermodynamic and spectrofluorimetric analysis

Keywords: بیماری آلزایمر; Amyloid peptides; Neuronal nitric oxide synthase; Alzheimer's disease; Kinetic; Thermodynamic; Spectrofluorimetric analysis; Dynamic quenching;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Intersite variability of CSF Alzheimer's disease biomarkers in clinical setting

Keywords: بیماری آلزایمر; Alzheimer's disease; Amyloid-β; Biomarkers; Cerebrospinal fluid; Tau; Variability;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian case-control cohorts

Keywords: بیماری آلزایمر; Sirtuin; Alzheimer's disease; SIRT2; SIRT3; APOE; Genetics;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

TOMM40 intron 6 poly-T length, age at onset, and neuropathology of AD in individuals with APOE ɛ3/ɛ3

Keywords: بیماری آلزایمر; Alzheimer's disease; Age at onset; Genetic; APOE; TOMM40; PSEN1 mutation; PSEN2 mutation; Neuropathology;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Novel BACE1 inhibitors with a non-acidic heterocycle at the P1′ position

Keywords: بیماری آلزایمر; Non-acidic inhibitor; β-Secretase; Alzheimer's disease; Quantitative structure-activity relationship; Hydroxymethylcarbonyl isostere;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Amyloid-β oligomer detection by ELISA in cerebrospinal fluid and brain tissue

Keywords: بیماری آلزایمر; Alzheimer's disease; Amyloid-β; Oligomers; ELISA; Brain tissue; CSF; Heterophilic antibodies;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Decisive role of Reelin signaling during early stages of Alzheimer's disease

Keywords: بیماری آلزایمر; Aβ; amyloid beta; AD; Alzheimer's disease; AON; anterior olfactory nucleus; ApoER2; apolipoprotein E receptor 2; APP; amyloid precursor protein; Dab-1; Disabled-1; GWA; genome-wide association; LTP; long term potentiation; MCI; mild cognitive impairmen

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3

Keywords: بیماری آلزایمر; Aβ; amyloid-β protein; AD; Alzheimer's disease; AMPAR; a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; DHPG; 3,5-dihydroxyphenylglycine; EPSP; excitatory postsynaptic potential; fEPSPs; field excitatory postsynaptic potentials; LTP; lon

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Time course study of Aβ formation and neurite outgrowth disruption in differentiated human neuroblastoma cells exposed to H2O2: Protective role of autophagy

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Aβ; Amyloid-β; AO/EB; acridine orange/ethidium bromide; Atg; autophagy related-gene; ECL; electrochemiluminescence; FBS; fetal bovine serum; H2O2; hydrogen peroxide; 3MA; 3-methyladenine; LC3B; microtubule-associated protein l

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Featured ArticlePotentially avoidable hospitalizations among Medicare beneficiaries with Alzheimer's disease and related disorders

Keywords: بیماری آلزایمر; Alzheimer's disease; Hospitalization; Comorbidity; Medicare expenditures; Quality of care; High-risk patients; Diabetes; Hypertension; CDPD/asthma; Heart failure;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

β-Amyloid-aluminum complex alters cytoskeletal stability and increases ROS production in cortical neurons

Keywords: بیماری آلزایمر; Alzheimer's Disease; Metal ions; Neurodegeneration; Oligomers;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Featured ArticleThe Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress

Keywords: بیماری آلزایمر; Cognitive impairment; Dementia; Alzheimer's disease; Lifestyle; Intervention; Randomized trial;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Dose-dependent folic acid and memantine treatments promote synergistic or additive protection against Aβ(25-35) peptide-induced apoptosis in SH-SY5Y cells mediated by mitochondria stress-associated death signals

Keywords: بیماری آلزایمر; Aβ(25-35); amyloid-β; AD; Alzheimer's disease; AV; annexin-V-FITC; CCCP; carbonyl cyanide 3-chlorophenylhydrazone; COX; cytochrome c oxidase; DCFH-DA; 2′,7′-dichlorodihydrofluorescin diacetate; DCF; 2′,7′-dichlorofluorescin; FA; folic acid;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Featured ArticleLongitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer's disease

Keywords: بیماری آلزایمر; Longitudinal; Alzheimer's disease; DTI; Anisotropy; Diffusivity;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه