دانلود مقالات ISI درباره بیماری آلزایمر + ترجمه فارسی

Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template

Keywords: بیماری آلزایمر; Glutaminyl cyclase; QC; Alzheimer's disease; Beta amyloid; Pyroglutamate; Enzyme inhibitor;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors

Keywords: بیماری آلزایمر; AChE; acetylcholinesterase; BuChE; butyrylcholinesterase; AD; Alzheimer's disease; AChEI; acetylcholinesterase inhibitors; Aβ; β-amyloid; PAS; peripheral anionic site; eeAChE; Electrophorus electricus AChE; TcAChE; Torpedo californica AChE; hAChE; hum

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Reduced expression of pain mediators and pain sensitivity in amyloid precursor protein over-expressing CRND8 transgenic mice

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; β-amyloid; CFA; complete Freud's adjuvant; CGRP; calcitonin gene-related peptide; DAB; 3,3′-diaminobenzidine; DRG; dorsal root ganglion; IB4; isolectin-4; i.pl.; intraplantar; NGS; norma

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Functional neuroanatomical correlates of the executive clock drawing task (CLOX) performance in Alzheimer's disease: A FDG-PET study

Keywords: بیماری آلزایمر; [18F]FDG-PET; 18F-fluoro-2-deoxy-glucose positron emission tomography; AD; Alzheimer's disease; BA; Brodmann area; CDR; Clinical Dementia Rating; CDR-SB; CDR-sum of boxes; CDTs; clock drawing tests; CERAD; Consortium to Establish a Registry for Alzheime

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; CR; calorie restriction; CREB; cAMP response binding protein; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetracetic acid; FBS; foetal bovine serum; FITC; fluorescein isothiocyanate; HEPES; 4-(2-hydroxyethyl)-1-piperazineetha

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

ReviewMolecular links between Alzheimer's disease and diabetes mellitus

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; APP; amyloid β precursor protein; BACE1; β-site APP-cleaving enzyme 1; Aβ; amyloid β protein; hIAPP; human islet amyloid polypeptide; IDE; insulin-degrading enzyme; IGF; insulin-like growth factor; GSK3β; glycogen synthase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity

Keywords: بیماری آلزایمر; Alzheimer's disease; berberine-thiophenyl hybrids; Inhibitors of AChE; β-Amyloid aggregation; Antioxidants;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

Keywords: بیماری آلزایمر; [18F]T807; Tau; Amyloid β; Alzheimer's disease; Imaging; Autoradiography;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer's disease patients

Keywords: بیماری آلزایمر; Lymphocytes; Alzheimer's disease; p21; Apoptosis; Calmodulin; CaMKII; ERK1/2; FOXO3;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Featured ArticleThe ADAS-Cog revisited: Novel composite scales based on ADAS-Cog to improve efficiency in MCI and early AD trials

Keywords: بیماری آلزایمر; Alzheimer's disease; MCI; Mild cognitive impairment; ADAS-Cog; Composite endpoints; Novel endpoints; Clinical trials; Power; Sample size; Ceiling effects;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Leukotriene D4 induces cognitive impairment through enhancement of CysLT1R-mediated amyloid-β generation in mice

Keywords: بیماری آلزایمر; Leukotriene D4; Cognition; Cysteinyl leukotriene receptor 1; Amyloid-β peptides; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Proteome-wide study of endoplasmic reticulum stress induced by thapsigargin in N2a neuroblastoma cells

Keywords: بیماری آلزایمر; 2-DE; two-dimensional electrophoresis; AD; Alzheimer's disease; BSA; bovine serum albumin; Calr; calreticulin; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; CV; coefficient of variation; DAVID; Database for Annotation, Visualisation

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Ach; acetylcholine; AchE; acetylcholinesterase; APP; amyloid precursor protein; BBB; blood brain barrier; DCC; N,N′-dicyclohexylcarbodiimide; DCF; 2,7-dichlorofluorescein; DCFH-DA; 2′,7′-dichlorodihydrofluorescein diacetat

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids

Keywords: بیماری آلزایمر; Alzheimer's disease; Cholinesterase; Monoamine oxidase-B;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

ATP-ases of synaptic plasma membranes in striatum: Enzymatic systems for synapses functionality by in vivo administration of l-acetylcarnitine in relation to Parkinson's Disease

Keywords: بیماری آلزایمر; AChE; acetylcholinesterase; AD; Alzheimer's Disease; ANOVA; analysis of variance; AP; action potentials; DTNB; 5,5′-dithiobis-(2-nitrobenzoic acid); EDTA; ethylenediamine tetraacetic acid; EGTA; ethylene glycol tetraacetic acid; HEPES; 4-(2-hydroxyeth

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Effects of different amyloid β-protein analogues on synaptic function

Keywords: بیماری آلزایمر; Amyloid-β protein; Long-term potentiation; Synaptic transmission; Dentritic spines; Methionine 35; Synaptophysin; PSD-95; mEPCS; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Potential therapeutic applications of differentiated induced pluripotent stem cells (iPSCs) in the treatment of neurodegenerative diseases

Keywords: بیماری آلزایمر; Aβ; amyloid-β; AD; Alzheimer's disease; ALS; amyotrophic Lateral Sclerosis; APP; amyloid precursor protein; BDNF; brain-derived neurotrophic factor; BM-MSCs; bone marrow-derived MSCs; DNA; deoxyribonucleic acid; EBs; embryoid bodies; ESC; embryonic st

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner

Keywords: بیماری آلزایمر; ANOVA; analysis of variance; HO-1; heme oxygenase 1; HSF1; heat shock factor 1; Hsc70; heat shock cognate 70; Hsp70; heat shock protein 70; PBS; phosphate-buffered saline; Parkinson's disease; Alzheimer's disease; heat shock protein 70; heat shock cog

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; ADYLC3; adenylyl cyclase 3; ATP; adenosine triphosphate; cAMP; cyclic adenosine monophosphate; CJD; Creutzfeldt-Jakob disease; CNG; cyclic nucleotide-gated; Gnal; olfactory G protein; GUS-β; β-glucuronidase; HSD; Honestly Si

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

ReviewPharmacological and toxicological insights to the South African Amaryllidaceae

Keywords: بیماری آلزایمر; AChE; acetylcholineserase; AD; Alzheimer's disease; CNS; central nervous system; COX; cyclo-oxygenase; DCM; dichloromethane; MIC; minimum inhibitory concentration; MBC; minimum bactericidal concentration; SI; selectivity index; T/C index; ratio of treat

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Research ReportEarly life nutrient restriction impairs blood-brain metabolic profile and neurobehavior predisposing to Alzheimer's disease with aging

Keywords: بیماری آلزایمر; Nutrient restriction; Alzheimer's disease; Insulin; Amyloid beta; Anxiety;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Neuroprotection of rat retinal ganglion cells mediated through alpha7 nicotinic acetylcholine receptors

Keywords: بیماری آلزایمر; ACh; acetylcholine; AD; Alzheimer's disease; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; α7 nAChR; α7 nicotinic acetylcholine receptor; ANOVA; analysis-of-variance; α-Bgt; α-bungarotoxin; Bcl2; B-cell lymphoma protein; CNS; central

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Okadaic acid-induced Tau phosphorylation in rat brain: Role of NMDA receptor

Keywords: بیماری آلزایمر; aCSF; artificial cerebrospinal fluid; AD; Alzheimer's disease; BSA; Bovine serum albumin; CaMKII; Ca2+/calmodulin-dependent protein kinase II; EDTA; ethylenediaminetetraacetic acid; ELT; escape latency time; GSK-3β; glycogen synthase kinase-3β; HEPES;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

Conformational restriction approach to β-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations

Keywords: بیماری آلزایمر; Alzheimer's disease; β-Secretase (BACE1); Conformational restriction; Cyclopropane; Isothermal titration calorimetry;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

A one-pot domino synthesis and discovery of highly functionalized dihydrobenzo[b]thiophenes as AChE inhibitors

Keywords: بیماری آلزایمر; Domino; Thiophenone; Malononitrile; Acetylcholinesterase; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2013 سفارش ترجمه

Neuroscience Forefront ReviewTargeting the neural extracellular matrix in neurological disorders

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; ADDLs; amyloid-derived diffusible ligands; BDNF; brain-derived neurotrophic factor; ChABC; chondroitinase ABC; CSPGs; chondroitin sulfate proteoglycans; ECM; extracellular matrix; GAG; glycosaminoglycan; HSPGs; heparan sulfate p

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2013 سفارش ترجمه

1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases

Keywords: بیماری آلزایمر; Alzheimer's disease; Anellated xanthines; Tetrahydropyrimido[2,1-f]purinediones; Adenosine A1 receptor antagonists; Adenosine A2A receptor antagonists; Caffeine derivatives; Monoamine oxidase B inhibitors; Parkinson's disease; Tricyclic compounds; Syn

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2013 سفارش ترجمه

Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies

Keywords: بیماری آلزایمر; Renin-angiotensin system; Angiotensin IV; Angiotensin-(1-7); AT4R; Alzheimer's disease; Cognition;

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2018 سفارش ترجمه

Leptin and ghrelin prevent hippocampal dysfunction induced by Aβ oligomers

Keywords: بیماری آلزایمر; ΔΨm; mitochondrial membrane potential; AD; Alzheimer's disease; Aβ; amyloid-beta peptide; AβO; Aβ oligomers; BSA; bovine serum albumin; DHE; dihydroethidium; DMSO; dimethyl sulfoxide; DTT; 1,4-dithiotreitol; ECF; enhanced chemifluorescence; EDTA; e

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

PPARγ regulates the mitochondrial dysfunction in human neural stem cells with tumor necrosis factor alpha

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; adenosine monophosphate-activated protein kinase; Aβ; beta-amyloid; DHE; dihydroethidium; hNSCs; human neural stem cells; NRF1; nuclear respiratory factor1; PCR; polymerase chain reacti

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis of novel cognition enhancers with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at γ-aminobutyric acid type A (GABAA) receptor

Keywords: بیماری آلزایمر; α7nACh-R; α7nicotinic acetylcoline receptor; AD; Alzheimer's disease; BMS; borane methylsulfide; Bz site/GABAA-R; benzodiazepine site on GABAA receptor; CMC; carboxymethylcellulose; CNS; central nervous system; DAZ; diazepam, 7-chloro-1-methyl-5-pheny

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Magnetic Resonance Spectroscopy in Common Dementias

Keywords: بیماری آلزایمر; Magnetic resonance spectroscopy; Dementias; Alzheimer's disease; N-Acetylaspartate; Mild cognitive impairment;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Research NewsCommon Alzheimer's Disease Research Ontology: National Institute on Aging and Alzheimer's Association Collaborative Project

Keywords: بیماری آلزایمر; Alzheimer's disease; Research ontology;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

PerspectiveComparison of International Working Group criteria and National Institute on Aging-Alzheimer's Association criteria for Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; Diagnosis; Biomarkers; Neuropsychology; MCI;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease

Keywords: بیماری آلزایمر; Oxindole; Neurofibirillary tangles; Tau protein; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors

Keywords: بیماری آلزایمر; Alzheimer's disease; γ-Secretase; Aβ42; APP-YAC; In vivo clearance;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Large-scale production of soluble recombinant amyloid-β peptide 1-42 using cold-inducible expression system

Keywords: بیماری آلزایمر; Aggregation-prone; Alzheimer's disease; Amyloid-β peptide 1-42; Cell viability; Cold induction; Soluble expression;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain

Keywords: بیماری آلزایمر; Alzheimer's disease; Amyloid; Brain; Mapt; Neurotoxicity; Neurodegeneration; Tau;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease model

Keywords: بیماری آلزایمر; Aβ42; amyloid-β-42; AD; Alzheimer's disease; dFOXO; Drosophila forkhead box subgroup O; JNK; Jun-N-terminal kinase; Alzheimer's disease; Apoptosis; dFOXO; Drosophila; Jun-N-terminal kinase;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

The Nogo receptor 2 is a novel substrate of Fbs1

Keywords: بیماری آلزایمر; Nogo receptor 2; Fbs1; SCF; Degradation; Proteasome; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Smaller quantal size and faster kinetics of single exocytotic events in chromaffin cells from the APP/PS1 mouse model of Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; APP/PS1; Chromaffin cell; Exocytosis; Amperometry; Amyloid beta;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Solid-state NMR analysis of the β-strand orientation of the protofibrils of amyloid β-protein

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Aβ; amyloid β; SP; senile plaque; NMR; nuclear magnetic resonance; HPLC; high performance liquid chromatography; MALDI-TOF-MS; matrix-assisted laser desorption/ionization time-of flight mass spectroscopy; FAB-MS; fast atom bom

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents

Keywords: بیماری آلزایمر; Alzheimer's disease; Indanone derivatives; Acetylcholinesterase inhibitors; Metal-chelating agents;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and biological evaluation of novel technetium-99m labeled phenylbenzoxazole derivatives as potential imaging probes for β-amyloid plaques in brain

Keywords: بیماری آلزایمر; Alzheimer's disease; β-Amyloid plaque; Technetium-99m; Phenylbenzoxazole; Imaging probe;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Design, synthesis, and evaluation of resveratrol derivatives as Aß1-42 aggregation inhibitors, antioxidants, and neuroprotective agents

Keywords: بیماری آلزایمر; Resveratrol derivatives; Alzheimer's disease; Aß aggregation; Antioxidant; Neuroprotective;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease

Keywords: بیماری آلزایمر; BYUCENOZTGVBAU-UHFFFAOYSA-M; DFMPGFLPNGLYSZ-UHFFFAOYSA-M; YNVCGZRAQOHCEC-UHFFFAOYSA-M; GUNZDBGLCFMCGT-UHFFFAOYSA-M; IPOZUTQBTFRBLZ-UHFFFAOYSA-N; IRPSTTBCEOBEMW-JHGYPSGKSA-M; Alzheimer's disease; Neurofibrillary tangles; Zebrafish; Cytotoxicity; Imaging;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Role of the C8gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

Keywords: بیماری آلزایمر; Bryostatin; Phorbol ester; Protein kinase C; Cancer; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Efficient synthesis and reaction pathway studies of novel fused morpholine oxadiazolines for use as gamma secretase modulators

Keywords: بیماری آلزایمر; Morpholine; Oxadiazoline; Cyclization; Heterocycles; Gamma secretase modulator; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Short ReportCardiovascular fitness is associated with altered cortical glucose metabolism during working memory in ɛ4 carriers

Keywords: بیماری آلزایمر; Apolipoprotein-E; ɛ4; Positron emission tomography; FDG-PET; Alzheimer's disease; Fitness; Sternberg working memory task; Working memory;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Hippocampal metabolites and memory performances in patients with amnestic mild cognitive impairment and Alzheimer's disease

Keywords: بیماری آلزایمر; Amnestic mild cognitive impairment; Alzheimer's disease; Proton magnetic resonance spectroscopy; N-acetylaspartate; Myo-inositol; Wechsler memory scale-revised;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه