دانلود مقالات ISI درباره Cyp + ترجمه فارسی

Azinphos-methyl and chlorpyrifos, alone or in a binary mixture, produce oxidative stress and lipid peroxidation in the freshwater gastropod Planorbarius corneus

Keywords: AChE; acetylcholinesterase; AZM; azinphos-methyl; BHT; butylated hydroxytoluene; CAT; catalase; CDNB; 1-chloro-2,4-dinitrobenzene; CES; carboxylesterases; CPF; chlorpyrifos; CYP; cytochrome P450; GR; glutathione reductase; G6PDH; glucose 6-phosphate dehyd

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticlePharmacokinetics and safety of co-administered paritaprevir plus ritonavir, ombitasvir, and dasabuvir in hepatic impairment

Keywords: HCV; hepatitis C virus; Cmax; maximal plasma concentration; AUC; area under the plasma concentration-time curve; DAA; direct-acting antiviral agent; NS; nonstructural; CYP; cytochrome P450; Paritaprevir/r; paritaprevir administered with ritonavir; SVR12;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Analysis of pooled phase III trials of adjunctive perampanel for epilepsy: Impact of mechanism of action and pharmacokinetics on clinical outcomes

Keywords: AE; adverse event; AED; antiepileptic drug; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; CYP; cytochrome P450; EIAED; enzyme-inducing antiepileptic drug; SCB; sodium channel blocker; TEAE; treatment-emergent adverse event; Perampanel; Par

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo

Keywords: ACN; acetonitrile; AMV-RT; avian myeloblastosis virus reverse transcriptase; BSA; bovine serum albumin; Ct; comparative threshold cycle; CYP; cytochrome P450; DAG; diclofenac acyl-glucuronide; DCF; diclofenac; DMSO; dimethylsulfoxide; DTNB; 5,5′-dithiob

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project

Keywords: AMI; amiodarone; ADR; adverse drug reaction; CPZ; chlorpromazine; CsA; cyclosporine A; CYP; cytochrome P450-dependent monooxygenases; DICI; Drug Induced Cholestasis Index; DILI; drug-induced liver injury; DME; drug metabolizing enzyme; IBU; ibuprofen; NSA

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Constitutive expression of the AHR signaling pathway in a bovine mammary epithelial cell line and modulation by dioxin-like PCB and other AHR ligands

Keywords: AHR; aryl hydrocarbon receptor; AHR; RAHR-repressor; ARNT; AHR-nuclear translocator; B[a]P; benzo[a]pyrene; β-NAF; β-naphthoflavone; CYP; cytochrome P450; cDNA; complimentary DNA; DL; dioxin-like; GST; glutathione S-transferase; NQO1; quinone oxidoreduc

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Effects of aflatoxin B1, fumonisin B1 and their mixture on the aryl hydrocarbon receptor and cytochrome P450 1A induction

Keywords: AFB1; aflatoxin B1; Ahr; aryl hydrocarbon receptor; AFBO; AFB1-exo-8,9-epoxide; βNF; β-naphthoflavone; Cyp; cytochrome P450; DRE; dioxin responsive elements; EROD; 7-ethoxyresorufin-O-deethylase; FB1; fumonisin B1; ERK; extracellular signal-regulated ki

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes

Keywords: Cytochrome P450; Structure-function relationship; Site-directed mutagenesis; Monooxygenase coupling; CYP; cytochrome P450; ITC; isothermal titration calorimetry; H/D; hydrogen deuterium; DXMS; H/D exchange coupled to mass spectrometry; SNP; single nucle

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo

Keywords: P-gp; P-glycoprotein; PCIS; Precision-Cut Intestinal Slices; R123; Rhodamine 123; DDI(s); drug-drug interaction(s); IC50; half maximal inhibitory concentration; ABC; ATP-binding cassette; CYP; cytochrome P450; CP100356; 4-(3,4-dihydro-6,7-dimethoxy-2(1H

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period

Keywords: CYP; cytochrome P450; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; LFC; log2 fold change; PPAR; peroxisome proliferator-activated receptor; HepaRG cells; Transcriptomics; PPAR agonists; Repeated treatments; Time-dependent changes; Gene profiling;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Modulating effect of synthetic statins against damage induced by doxorubicin in somatic cells of Drosophila melanogaster

Keywords: Atorvastatin; Rosuvastatin; Modulatory effect; Smart; Drosophila melanogaster; BH; balancer heterozygote descendants; CYP; cytochrome P450; CYP2C9; cytochrome P450 2C9; CYP 2C19; cytochrome P450 2C19; DXR; doxorubicin; eNOS; endothelial nitric oxide synth

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Functional characterization of CYP1A9 and CYP1C1 from Anguillus japonica

Keywords: Fish; HPLC; CYP; Monooxygenase; progesterone; P450; Site-directed mutagenesisCYP, Cytochrome P450; IPTG, isopropyl-thio-β-D-thiogalactopyranoside; ANF, α-naphthoflavone

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Metabolomic analysis revealed the role of DNA methylation in the balance of arachidonic acid metabolism and endothelial activation

Keywords: AA; arachidonic acid; COX; cyclooxygenases; LOX; lipoxygenases; CYP; cytochrome P450; EETs; epoxyeicosatrienoic acids; HETEs; hydroxyeicosatetraenoic acids; PGs; prostaglandins; PGD2; prostaglandin D2; PTGDS; prostaglandin D2 synthase; TXB2; thromboxane B

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats

Keywords: AUC; area under the curve; AUs; action units; CFA; complete Freund's adjuvant; CYP; cyclophosphamide; DRG; dorsal root ganglia; HEK; human embryonic kidney; NMDA; N-Methyl-d-aspartate; PBS; phosphate-buffered saline; RGS; rat grimace scale; ROS; reactiv

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Mechanisms and latest clinical studies of new NK1 receptor antagonists for chemotherapy-induced nausea and vomiting: Rolapitant and NEPA (netupitant/palonosetron)

Keywords: AE; adverse event; AUC; area under the curve; 5-HT3; serotonin subtype 3; CINV; chemotherapy-induced nausea/vomiting; Cmax; maximum serum concentration; CNS; central nervous system; CR; complete response; CYP; cytochrome P450; ECG; electrocardiogram; FLIE

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Reference gene validation for qRT-PCR based gene expression studies in different developmental stages and under biotic stress in apple

Keywords: 18S; 18S ribosomal RNA; ACT; actin; APRT; adenine phosphoribosyl transferases; CT; cycle threshold; CYP; cyclophilin; EF-1α; elongation factor-1α; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; PP2A; protein phosphatase 2A; qRT-PCR; quantitative real-

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

The effect of antibiotic exposure on eicosanoid generation from arachidonic acid and gene expression in a primitive chordate, Branchiostoma belcheri

Keywords: Chl; chloramphenicol; AA; arachidonic acid; Amp; ampicillin; COX; cyclooxygenase; LOX; lipoxygenases; CYP; mono-oxygenases from cytochrome P450; Amphioxus; Chloramphenicol; Ampicillin; Immune system; Eicosanoid;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Noscapine recirculates enterohepatically and induces self-clearance

Keywords: ACN; Acetonitrile; Cap; capsaicin; Cur; curcumin; CYP; cytochrome P450; DLM; dog liver microsomes; DMSO; Dimethylsulfoxide; Eu; eugenol; IC50; inhibitory concentration 50%; HLM; human liver microsomes; LC-MS/MS; liquid chromatography tandem mass spectro

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Differential expression and regulation of vitamin D hydroxylases and inflammatory genes in prostate stroma and epithelium by 1,25-dihydroxyvitamin D in men with prostate cancer and an in vitro model

Keywords: 1α,25(OH)2D; 1α,25-dihydroxyvitamin D3; PCa; prostate cancer; VDR; vitamin D receptor; CYP; cytochrome P450; LCM; laser capture microdissection; RT; reverse transcription; qPCR; quantitative polymerase chain reaction; PTGS2 or COX2; prostaglandin syntha

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Determination of species-difference in microsomal metabolism of amitriptyline using a predictive MRM-IDA-EPI method

Keywords: Amitriptyline; CYP; UGT; Metabolic stability; Metabolite identification;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants

Keywords: CPA; cyclophosphamide; IFA; ifosfamide; CYP; cytochrome P450; 4-OH-CPA; 4-hydroxycyclophosphamide; 4-OH-IFA; 4-hydroxyifosfamide; PM; phosphoramidemustard; IM; ifosforamide mustard; CAA; chloroacetylaldehyde; GDEPT; gene-directed enzyme prodrug therapy; C

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs

Keywords: CYP; Gene expression; H4IIE; Mixtures; PAHs; TCDD

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11β-Hydroxylase

Keywords: 11β-hydroxylase; Human and rat CYP11B1; Inhibitors; Cushing's syndrome; Selectivity; Aromatase; CYP; cytochrome P450; hCYP11B1; steroid 11β-hydroxylase; hCYP11B2; aldosterone synthase; hCYP17; 17α-hydroxylase-17,20-lyase; hCYP19; aromatase; SF; selecti

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates

Keywords: CYP; cytochrome P450 (specific isoforms); SDHA; succinate dehydrogenase; SERCA; sarco/endoplasmic reticulum Ca2+-ATPase; CYP2E1; Cooperativity; Styrene; Aniline; 4-Nitrophenol; Mitochondrial transport;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production

Keywords: AO; aldehyde oxidase; ANA; antinuclear antibody; AADAC; arylacetamide deacetylase; BNPP; bis(4-nitrophenyl)phosphate; CES; carboxylesterase; CYP; cytochrome P450; DTNB; 5,5′-dithiobis(2-nitrobenzoic acid); EDTA; ethylenediamine-N,N,N′N′-tetraacetic

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Troxerutin protects against 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47)-induced liver inflammation by attenuating oxidative stress-mediated NAD+-depletion

Keywords: Polybrominated diphenyl ethers; Oxidative stress; NAD+; Inflammation; Troxerutin; AC-H3K9; acetyl-histone H3 (Lys9); AC-p65 (K310); acetyl-NF-κB p65 (Lys310); ALT; alanine aminotransferase; BDE-47; 2,2′,4,4′-tetrabromodiphenyl ether; CYP; cytochrome

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies

Keywords: AA; arachidonic acid; a.m.u.; atomic mass unit; a.u.; arbitrary units; CYP; cytochrome P450; Deb; debrisoquine; 1- 3-, 4-, 5-, 6-, 7- and 8-OH-Deb; 1-, 3-, 4-, 5-, 6-, 7-, and 8-hydroxy-debrisoquine, respectively; N-OH-Deb; N-hydroxy-debrisoquine; Deb-ure

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane

Keywords: Estrogen receptor-positive breast cancer; Aromatase inhibitors; Exemestane metabolites; Apoptosis; Autophagy; Acquired-resistance; AIs; aromatase inhibitors; AO; acridine orange; AVOs; acid vesicular organelles; CCCP; carbonyl cyanide m-chlorophenylhydraz

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Liver maturation deficiency in p57Kip2−/− mice occurs in a hepatocytic p57Kip2 expression-independent manner

Keywords: Afp; α-fetoprotein; Bmp; bone morphogenic proteins; C/EBPα; CCAAT/enhancer-binding protein α; CK; cytokeratin; CKI; cyclin-dependent kinase inhibitor; Cyp; cytochrome P450; DAPI; 4′,6-diamidino-2-phenylindole dihydrochloride; Dlk1; delta-like 1 homol

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6

Keywords: Cyps; cyclophilins; FKBPs; immunophilins; FKBD; FK506-binding domain; ER; rough endoplasmic reticulum; SERCA; sarco-endoplasmic Ca2+-ATPase; IP3Rs; inositol 1,4,5-trisphosphate receptors; IP3; inositol 1,4,5-trisphosphate; TRPC; transient receptor potenti

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation

Keywords: ALCL; anaplastic large cell lymphoma; ALOX; lipoxygenase A; CCID; circular chemorepellent induced defect; CYP; cytochrome P450; DCM; dichloromethane extract; EROD; ethoxyresorufin-O-deethylase; HO/PI; Hoechst 33258/propidium iodide; LEC; lymph endothelial

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Permanent uncoupling of male-specific CYP2C11 transcription/translation by perinatal glutamate

Keywords: CHIP; chromatin immunoprecipitation; CYP; cytochrome P450; GH; growth hormone; GHR; growth hormone receptor; HYPOX; hypophysectomized; JAK; Janus kinase; miRNA; microRNA; MSG; monosodium glutamate; pSTAT5b; phospho signal transducers and activators of tra

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation

Keywords: Neurolenins; NPM/ALK; ALCL; Intravasation; 3D-compound testing; Toxicity; ALCL; anaplastic large cell lymphoma; ALOX; lipoxygenase A; CCID; circular chemorepellent induced defect; CYP; cytochrome P450; DME; dichloro methane extract; EROD; ethoxyresorufin-

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis

Keywords: ABC; ATP-binding cassette; ACN; acetonitrile; ADH; alcohol dehydrogenase(s); ALDH; aldehyde dehydrogenase(s); b. w.; body weight; CYP; cytochrome P450 monooxygenase(s); Em; echimidine; GST; glutathione S-transferase(s); Hn; heliotrine; i. p.; intraperiton

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Quantitative in vitro to in vivo extrapolation of tissues toxicity

Keywords: ADME; absorption, distribution, metabolism, and excretion; ARE; antioxidant responses elements; BBB; blood brain barrier; CsA; cyclosporine A; CYP; cytochrome P450; EPA; Environmental Protection Agency; GCL; glutamate cysteine ligase; GCLC; glutamate cyst

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence

Keywords: CBR; cytochrome b5 reductase; b5; cytochrome b5; CPR; cytochrome P450 reductase; CYP; cytochrome P450; STB; Septoria tritici blotch; DPI; days post inoculation; WT; wild-type; HPLC; high pressure liquid chromatography; GC-MS; gas chromatography-mass s

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure-activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase

Keywords: TB; tuberculosis; Mtb; Mycobacterium tuberculosis; MIC; minimal inhibitory concentration; CYP; cytochrome P450; SAR; structure-activity relationships; MMIC; mammalian cytotoxicity; DprE1; decaprenylphosphoryl-β-d-ribose 2′-oxidase; TEA; triethylamine

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

Herbal Products and the Liver: A Review of Adverse Effects and Mechanisms

Keywords: Dietary Supplement Health and Education Act; Contamination and Adulteration; Herbal Therapie; sSilymarin; ALT; alanine aminotransferase; CAM; complementary and alternative medicine; CHC; chronic hepatitis C; CYP; cytochrome P450; DILI; drug-induced liver

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2015 سفارش ترجمه

In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

Keywords: ADME; absorption, distribution, metabolism and excretion; AFs; aflatoxins; ALT; alanine aminotransferase; HFB1; aminopentol; AS; aluminosilicate; AST; aspartate aminotransferase; AUC; area under curve; BEA; beauvericin; bw; body weight; CAT; catalase; CYP

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2015 سفارش ترجمه

Incorporation of charged residues in the CYP2J2 F-G loop disrupts CYP2J2-lipid bilayer interactions

Keywords: CYP; cytochrome P450; ER; endoplasmic reticulum; ND; nanodisc; PYR; pyrene; PYR-PC; pyrene phosphatidylcholine; MD; molecular dynamics; HMMM; highly mobile membrane mimetic; POPC; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPS; 1-hexadecanoyl-2-(9

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2015 سفارش ترجمه

Beyond Triphos - New hinges for a classical chelating ligand

Keywords: R′EP3R; in general structures with general formula R′E(CH2PR2)3; AACVD; aerosol-assisted chemical vapour deposition; acac; acetylacetone; ATRA; atom-transfer radical additions; ATRP; atom-transfer radical polymerization; cod; 1,5-cyclooctadiene; Cp−

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2015 سفارش ترجمه

Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor

Keywords: AhR; arylhydrocarbon receptor; CAR; constitutive androstane receptor; CYP; cytochrome P450; DMSO; dimethylsulphoxide; DBD; DNA binding domain; LBD; ligand binding domain; NBH; New Bedford Harbor; PCR; polymerase chain reaction; PXR; pregnane-X-receptor; P

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2015 سفارش ترجمه

Alisporivir Inhibition of Hepatocyte Cyclophilins Reduces HBV Replication and Hepatitis B Surface Antigen Production

Keywords: Cyclophilin Inhibition; Direct-Acting Antiviral Agent; Peptidyl-Prolyl Isomerase; Viral Replication; ALV; alisporivir; BL; baseline; CYP; cyclophilin; DMEM; Dulbecco's modified Eagle medium; DMSO; dimethyl sulfoxide; ELISA; enzyme-linked immunosorbent a

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2015 سفارش ترجمه

Zebrafish: An Important Tool for Liver Disease Research

Keywords: Development; Technology; Liver Cancer; Toxicology; Regeneration; ALD; alcoholic liver disease; CYP; cytochrome P450; DILI; drug-induced liver injury; DMBA; dimethylbenzanthracene; dpf; days postfertilization; ER; endoplasmic reticulum; FLD; fatty liver di

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2015 سفارش ترجمه

Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury

Keywords: 4-HNE; 4-hydroxynonenal; ARDS; acute respiratory distress syndrome; ALI; acute lung injury; AHR; aryl hydrocarbon receptor; CYP; cytochrome P450; ELISA; enzyme-linked immunosorbent assay; EROD; ethoxyresorufin O-deethylase; GC-MS; gas chromatography-m

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2015 سفارش ترجمه

Impact of inhalational exposure to ethanol fuel on the pharmacokinetics of verapamil, ibuprofen and fluoxetine as in vivo probe drugs for CYP3A, CYP2C and CYP2D in rats

Keywords: Ethanol fuel; Inhalation; Pharmacokinetics; CYP3A; CYP2C; CYP2D; ACGIH; American Conference of Governmental Industrial Hygienists; AUC0-∞; area under the curve plasma concentration versus time over the infinite time interval; Cl/F; apparent total clea

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2015 سفارش ترجمه

Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities

Keywords: ACAT; acyl CoA:cholesterol acyltransferase; ADME; absorption, distribution, metabolism and excretion; APCI; atomospheric pressure chemical ionization; CM; chylomicron; dba; dibenzylideneacetone; CYP; cytochrome P450; DDI; drug-drug interaction; DGAT; ac

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2015 سفارش ترجمه

Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

Keywords: Coumarins; Anticancer; Synthesis; Targets; SAR; IC50; ARI; aromatase inhibitor; CAM; choriallanotoic membrane; CDC; cell cycle division protein; CDK2; cyclin dependent kinase 2; CDKN1A; cyclin-dependent kinase inhibitor 1A; CYP; cytochromes P450; DDIT4; D

دانلود رایگان متن کامل مقاله ISI 72 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors

Keywords: 5-HT; serotonin; NE; norepinephrine; DA; dopamine; SSRI; selective serotonin reuptake inhibitor; SNRI; serotonin norepinephrine reuptake inhibitor; TRI; triple reuptake inhibitor; CYP; cytochrome P450; hERG; human ether-a go-go-related gene; HEK; human em

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

The phenolic metabolites of the anti-HIV drug efavirenz: Evidence for distinct reactivities upon oxidation with Frémy's salt

Keywords: Efavirenz; Phenolic metabolites; Oxidation; Quinone-imine; Quinoline; Anti-HIV drug; CYP; cytochrome P450; EFV; efavirenz; ESI; electrospray ionization; HIV; human immunodeficiency virus type 1; HPLC-DAD; high performance liquid chromatography with diod

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه