Autophagy contributes to gefitinib-induced glioma cell growth inhibition
Keywords: AMPK; Autophagy; EGFR; Gefitinib; Glioma;
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Decorin deficiency promotes hepatic carcinogenesis
Keywords: SLRP; small leucine-rich proteoglycan; RTK; receptor tyrosine kinase; TA; thioacetamide; DEN; diethyl nitrosamine; HCC; hepatocellular carcinoma; Dcnâ/â; decorin null; WT; wild type; p21WAF1/CIP1; cyclin-dependent kinase inhibitor p21; AP4; transcript
A systematic review of dual targeting in HER2-positive breast cancer
Keywords: ADCC; antibody-dependent cell-mediated cytotoxicity; ASCO; American Society of Clinical Oncology; CBR; clinical benefit rate; CHF; congestive heart failure; CI; confidence interval; DFS; disease free survival; EGFR; epidermal growth factor receptor; ER; e
Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling
Keywords: LPA; lysophosphatidic acid; LPAR; LPA receptor; ERK; extracellular signal-related kinase, p44/42 MAP kinase; GPCR; G-protein coupled receptor; ROS; reactive oxygen species; Nox; NADPH oxidase; EGF; epidermal growth factor; EGFR; EGF receptor; PDGF; platel
Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux
Keywords: ABC; ATP-binding cassette transporter; AcLDL; acetylated LDL; apo; apolipoprotein; BSA; bovine serum albumin; CAV1; caveolin-1; CL; cytoplasmic loop; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; EGFR; epidermal growth f
Nucleolin enhances internal ribosomal entry site (IRES)-mediated translation of Sp1 in tumorigenesis
Keywords: Sp1; IRES; Nucleolin; Phosphorylation; EGFR;
Cbl-family ubiquitin ligases and their recruitment of CIN85 are largely dispensable for epidermal growth factor receptor endocytosis
Keywords: EGFR; epidermal growth factor receptor; CIN85; Cbl interacting protein of 85Â kDa; Cbl; casitas B-lineage lymphoma; EEA1; early endosome antigen 1; FACS; fluorescence-activated cell sorting; PFA; paraformaldehyde; mAb; monoclonal antibody; pAb; polyclonal
Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-β1-mediated anchorage
Keywords: Angiogenesis; GD3; Integrin-β1; Pancreatic ductal adenocarcinoma; S phase; B-MAA; biotinylated-Maackia amurensis lectin; b-FGF; basic fibroblast growth factor; B-SNA; biotinylated-Sambucus nigra lectin; DAPI; 4â²,6-diamidino-2-phenylindole; ECM; extra-c
Secretory Hyperresponsiveness and Pulmonary Mucus Hypersecretion
Keywords: BAC; bronchoalveolar carcinoma; BHR; bronchial hyperresponsiveness; CDA; cough-dominant asthma; CF; cystic fibrosis; EGFR; epidermal growth factor receptor; ERK; extracellular-regulated kinase; LPS; lipopolysaccharide; MEC; mucoepidermoid carcinoma; MLS;
Caveolin-1 promotes gastric cancer progression by up-regulating epithelial to mesenchymal transition by crosstalk of signalling mechanisms under hypoxic condition
Keywords: Cav-1; caveolin-1; EGFR; epidermal growth factor receptor; EMT; epithelial to mesenchymal transition; pSTAT3; Phosphorylated Signal transducer and activator of transcription 3; pSMAD3; phosphorylated Mothers against decapentaplegic homolog 3; FITC; Fluore
Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: Focus on the role and impact of proteoglycans
Keywords: ER; estrogen receptor; PgR; progesterone receptor; HER2/erbB2; human epidermal growth factor receptor-2; E2; estradiol; RTK; receptor tyrosine kinase; IGF-IR; insulin-like growth factor I receptor; EGFR; epidermal growth factor receptor; MAPK; mitogen act
Biological, diagnostic and therapeutic relevance of the MET receptor signaling in head and neck cancer
Keywords: Head and neck cancer; MET receptor tyrosine kinase; Targeted therapy; Prognostic impact; Treatment resistance; CSC; cancer stem-like cell; DDR; DNA damage response; ECM; extracellular matrix; EGFR; epidermal growth factor receptor; Egr-1; early growth res
β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt
Keywords: ANOVA; analysis of variance; AR; adrenergic receptor; EGFR; epidermal growth factor receptor; ELISA; enzyme-linked immunosorbent assay; GPCR; G protein-coupled receptor; HF; heart failure; ISO; Isoproterenol; LDH; lactate dehydrogenase; RNCM; rat neonatal
Biomarkers for virus-induced hepatocellular carcinoma (HCC)
Keywords: AFP; α-fetoprotein; HCC; hepatocellular carcinoma; HBV/HCV; Hepatitis B virus/C virus; DCP; des-gamma-carboxy prothrombin; GP73; Golgi protein; GPC3; Glypican-3; CD10; Cluster of differentiation 10; CD36; Cluster of differentiation 36; SAGE; serial analy
Annexins - Scaffolds modulating PKC localization and signaling
Keywords: AKAP; A-kinase-anchoring protein; Anx; annexin; Ca2Â +; calcium; DAG; diacylglycerol; EGFR; epidermal growth factor receptor; HSP; heat shock protein; IP3; inositol triphosphate; MAPK; mitogen-activated protein kinase; PI(4,5)P2; phosphoinositide 4,5-biph
HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4)
Keywords: MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; MAP3K4; mitogen-activated protein kinase kinase kinase 4; MEKK4; mitogen-activated, extracellular signal-regulated kinase kinase; MTK1; mitogen activated protein three kin
Effects of activated fibroblasts on phenotype modulation, EGFR signalling and cell cycle regulation in OSCC cells
Keywords: Akt; protein kinase B; CAF; cancer associated fibroblast; EGFR; epidermal growth factor receptor; EMT; epithelial mesenchymal transition; ERK; extracellular signal-regulated protein kinase; FCM; fibroblast conditioned medium; HNSCC; head and neck squamous
Sialosignaling: Sialyltransferases as engines of self-fueling loops in cancer progression
Keywords: ALL; acute lymphocytic leukemia; AML; acute myeloblastic leukemia; 5-AZA; 5â²-azacytidine; BCG; Bacillus Calmette-Guerin; CIN; chromosome instability; DP; degree of polymerization; ECM; extracellular matrix; EGF; epidermal growth factor; EGFR; epiderma
Expression of zebrafish anterior gradient 2 in the semicircular canals and supporting cells of otic vesicle sensory patches is regulated by Sox10
Keywords: agr2; anterior gradient 2; cls; colorless; DIC; Differential interference contrast; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; ERK; Extracellular Signal-regulated Kinase; Fgf; fibroblast growth factor; EMSA; electrophoretic mobilit
Circulating tumor-cell detection and capture using microfluidic devices
Keywords: BM; Bone marrow; CTC; Circulating tumor cell; DEP; Dielectrophoresis; EGFR; Epithelial growth factor receptor; EpCAM; Epithelial cell adhesion molecule; HeLa; Cervical cancer cell line; HER; Human epidermal growth factor receptor; LNCaP; Androgen-sensitiv
Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors
Keywords: Quinazoline; EGFR; VEGFR-2; Antitumor; Cancer
A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology
Keywords: RAS; renin-angiotensin system; AOG; angiotensinogen; Ang II; angiotensin II; ACE; angiotensin converting enzyme; ARBs; angiotensin AT1 receptor blockers; Mas R; Mas receptor; TGF-β; transforming growth factor-β; Ang A; angiotensin A; eNOS; endothelial
Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics
Keywords: Breast cancer; Receptor tyrosine kinase; Small molecule inhibitor; Senescence; Polyploidy; mTOR signaling; Chemosensitivity; AXL; Greek word anexelekto; BCR; breakpoint cluster region; BRAF; B-Rapidly Accelerated Fibrosarcoma; DAPI; 4â²,6â²-diamidino-2-
Down-regulation of lipid raft-associated onco-proteins via cholesterol-dependent lipid raft internalization in docosahexaenoic acid-induced apoptosis
Keywords: Docosahexaenoic acid (DHA); Lipid raft; Hsp90; EGFR; Akt; Cholesterol
Are erlotinib and gefitinib interchangeable, opposite or complementary for non-small cell lung cancer treatment? Biological, pharmacological and clinical aspects
Keywords: Lung cancer; Gefitinib; Erlotinib; Tyrosine kinase; EGFR; NSCLC
G protein-coupled receptors as oncogenic signals in glioma: Emerging therapeutic avenues
Keywords: Anx A1; Annexin 1; ATX; autaxin; cAMP; cyclic-AMP; CDK; cyclin-dependent kinase; CDKI; CDK inhibitor; ECM; extracellular matrix; EGFR; epidermal growth factor receptor; fMLF; N-formyl-methionyl-leucyl-phenylalanine; FPR; formyl peptide receptor; GBM; glio
Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model
Keywords: 3D tumor model; Boolean model; EMT; Invasion; Personalized medicine; Targeted therapy; BioVaSc; Biological Vascularized Scaffold; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; MUC1; mucin-1; PI; proliferation index; TGF
DNA Testing and Molecular Screening for Colon Cancer
Keywords: Genetics; Heredity; Colon Cancer; Fecal DNA Test; Polyposis; CLIA; Clinical Laboratories Improvement Act; CRC; colorectal cancer; EGFR; epidermal growth factor receptor; FIT; fecal immunochemical test; FOBT; fecal occult blood test; MMR; mismatch repair;
Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses
Keywords: Janus kinase 1/3; asthma; TH2; AHR; Airway hyperresponsiveness; BAL; Bronchoalveolar lavage; BFA; Brefeldin A; EGF; Epidermal growth factor; EGFR; Epidermal growth factor receptor; EPO; Erythropoietin; FACS; Fluorescence-activated cell sorting; Foxp3; For
Cetuximab Induces Eme1-Mediated DNA Repair: a Novel Mechanism for Cetuximab Resistance
Keywords: BRCA1; breast cancer tumor suppressor 1; BrdU; bromodeoxyuridine (5-bromo-2'-deoxyuridine); Chk; checkpoint kinase; DDR; DNA damage response; EGFR; epidermal growth factor receptor; Eme1; essential meiotic endonuclease 1 homolog 1; Erk; extracellular sign
Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic activity
Keywords: Pyrrolo[3,4-h]quinazolines; Antiproliferative activity; Antimitotic activity; Tubulin polymerization; Vascular disrupting activity; AO; acridine orange; EGFR; Epidermal Growth Factor Receptor; FITC; fluorescein isothiocyanate; H2DCFDA; 2â²,7â²-dichlorod
PI3K Regulation of RAC1 Is Required for KRAS-Induced Pancreatic Tumorigenesis in Mice
Keywords: Pancreatic Cancer; Signal Transduction; Cytoskeleton; Oncogene; ADM; acinar-to-ductal metaplasia; DAPI; 4â²,6-diamidino-2-phenylindole; EGFR; epidermal growth factor receptor; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GEF; guanine nucleotide excha
The structural basis of action of vanadyl (VO2+) chelates in cells
Keywords: acac; acetylacetonate, as in bis(acetylacetonato)oxidovanadium(IV) or VO(acac)2; alx; allixin; ASP; acylation-stimulating protein; CHO; Chinese hamster ovary; ENDOR; electron nuclear double resonance; EGFR; epidermal growth factor receptor; EPR; electron
A Summary and Critical Assessment of the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Disease Risk in Adults: Filling the Gaps
Keywords: A to Z; Aggrastat to Zocor; ABI; ankle-brachial index; ACC/AHA; American College of Cardiology/American Heart Association; ACCORD; Action to Control Cardiovascular Risk in Diabetes; AFCAPS-TexCAPS; Air Force/Texas Coronary Atherosclerosis Prevention Study
Summary of 2013 ESH/ESC Guidelines for the management of arterial hypertension
Keywords: ABPM; ambulatory blood pressure monitoring; ACE; angiotensin converting enzyme; ARB; angiotensin II receptor blocker; BP; blood pressure; CHD; coronary heart disease; CKD; chronic kidney disease; CV; cardiovascular; DBP; diastolic blood pressure; ECG; ele
MicroRNA expression profiling of thymic epithelial tumors
Keywords: microRNAs; Thymic epithelial tumors; miR-145; EGFR;
Agile delivery of protein therapeutics to CNS
Keywords: Aβ; amyloid β; Ab-InsR; antibodies against insulin receptor; Ab-TfR; antibodies against transferrin receptor; AD; Alzheimer's disease; Aerosol OT; bis-(2-ethylhexyl) sulfosucciate; ALS; amyotrophic lateral sclerosis; ApoB; apolipoprotein B; ApoE; apolip
Activation of EGFR and ERBB2 by Helicobacter pylori Results in Survival of Gastric Epithelial Cells With DNA Damage
Keywords: Marker; Prognostic Factor; Risk; Signal Transduction Pathways; EGFR; epidermal growth factor receptor; ERBB; erythroblastic leukemia-associated viral oncogene B; GC; gastric cancer; IM; intestinal metaplasia; ImSt; immortalized stomach; mRNA; messenger RN
PARP and other prospective targets for poisoning cancer cell metabolism
Keywords: ATP; adenosine 5â²-triphosphate; 3-BrPA; 3-bromopyruvate; EGFR; epidermal growth factor receptor; FDA; food and drug administration; GSH; glutathione; GSSG; oxidized GSH; GST; glutathione S-transferase; HDAC; histone deacetylase; HIF1; hypoxia inducible
AKT inhibition synergistically enhances growth-inhibitory effects of gefitinib and increases apoptosis in non-small cell lung cancer cell lines
Keywords: NSCLC; EGFR; AKT; S6; Gefitinib; Akt inhibitor; Synergism;
BRAF inhibitors in cancer therapy
Keywords: BRAF mutation; BRAF inhibitors; Cancer therapy; Resistance mechanisms; Combination therapy; EGFR; epidermal growth factor receptor; MAPK; mitogen-activated protein kinase; PI3K; phosphatidylinositol-4,5-bisphosphate 3-kinase; PFS; progression free surviva
CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation
Keywords: NSCLC; CIP2A; Erlotinib; PP2A; Apoptosis; EGFR;
The protein kinases TPL2 and EGFR contribute to ERK1/ERK2 hyper-activation in CFTRÎF508-expressing airway epithelial cells exposed to Pseudomonas aeruginosa
Keywords: AEC; airway epithelial cells; CF; cystic fibrosis; CFTR; CF transmembrane regulator; EGF; epidermal growth factor; EGFR; EGF receptor; ERK; extracellular signal-regulated kinase; MAPK; mitogen activated protein kinase; PsaDM; P. aeruginosa diffusible mate
Chronic kidney disease and percutaneous coronary interventions with drug-eluting stents: Does the K/DOQI classification matter?
Keywords: Chronic kidney disease; eGFR; Drug-eluting stent; Percutaneous coronary intervention; Renal dysfunction;
Transformation to “high grade” neuroendocrine carcinoma as an acquired drug resistance mechanism in EGFR-mutant lung adenocarcinoma
Keywords: Adenocarcinoma; EGFR; Mutation; Neuroendocrine; NSCLC; SCLC;
High-dose, pulsatile erlotinib in two NSCLC patients with leptomeningeal metastases-One with a remarkable thoracic response as well
Keywords: Lung cancer; Leptomeningeal metastases; Erlotinib; EGFR; Pulsatile dosing; TKI;
Mucous hypersecretion and relationship to cough
Keywords: Cough; Mucins; Mucous hypersecretion; EGFR; Mucous plugging; Positive feedback;
Long-term survival after hospitalization for acute heart failure - Differences in prognosis of acutely decompensated chronic and new-onset acute heart failure
Keywords: ACEI/ARB; angiotensin converting enzyme inhibitor/angiotensin receptor blocker; AHF; acute heart failure; ACS; acute coronary syndrome; ADCHF; acutely decompensated chronic heart failure; LVEF; left ventricular ejection fraction; eGFR; estimated glomerula
Regular ArticleTreatment with everolimus is associated with a procoagulant state
Keywords: AMC; Academic Medical Center; APC; activated protein C; APCsr; APC sensitivity ratio; APTT; activated partial thromboplastin time; AUC; area under the curve; CKD; chronic kidney disease; CNI; calcineurin inhibitor; CsA; cyclosporine A; eGFR; estimated GFR
Association of high post-transplant soluble CD30 serum levels with chronic allograft nephropathy
Keywords: Ab; Antibody; ah; Arteriolar hyaline thickening; AUC; Area under the curve; AZA; Azathioprine; CAN; Chronic allograft nephropathy; CI; Confidence interval; cg; Glomerulopathy; ci; Interstitial fibrosis; ct; Tubular atrophy; cv; Vascular fibrous intimal th