Epac2-mediated dendritic spine remodeling: Implications for disease
Keywords: Dendritic spine; Autism; Neuroligin; GEF; Rap; GTPase; GluR2; cAMP; Dopamine;
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The Fc receptor-cytoskeleton complex from human neutrophils
Keywords: AEBSF; 4-(2-Aminoethyl) benzenesulfonyl fluoride; CID; Collision-induced dissociation; Da; Dalton; ESI; electro spray ionization; GAP; GTPase activating protein; GEF; guanine exchange factor; HPMI; HEPES Park Memorial Institute; LARC; live-cell affinity r
Cellular signaling of Dock family proteins in neural function
Keywords: GEF; Neuronal cells; Glial cells; Dock180-related proteins; Rho GTPase;
Non-canonical functions of RGS proteins
Keywords: AC; adenylyl cyclase; CHO; Chinese hamster ovary; CNK1; connector enhancer of KSR1; CREB; cAMP-response element binding protein; DH; dbl-homology; DMAP1; Dnmt1-associated protein 1; EGF; epidermal growth factor; eIF; eukaryotic initiation factor; ERK; ext
RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways
Keywords: RGS; regulators of G protein signalling; RBD; Ras/Rap binding domain; GPCR; G protein coupled receptor; MAPkinase; Mitogen-activated protein kinases; GPR/GoLoco (GL); G protein regulatory motif; GEF; guanine exchange factor; GDI; guanine nucleotide dissoc
Vav1 couples the T cell receptor to cAMP response element activation via a PKC-dependent pathway
Keywords: Vav; GEF; T cell receptor; CRE
Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo
Keywords: Axon pathfinding; Xenopus; GEF; Rac1; L1; Commissural interneuron; Growth cone
Actin cytoskeleton dynamics and the cell division cycle
Keywords: APC; adenomatous polyposis coli; CDK1; cyclin-dependent kinase 1; ECM; extra cellular matrix; FAK; focal adhesion kinase; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; MLCK; myosin light chain kinase; PAK; p21-activate kinase; P
Differential distribution of exchange proteins directly activated by cyclic AMP within the adult rat retina
Keywords: PKA; immunohistochemistry; PDE; CNG; Rap; H89; BCA; bicinchoninic acid; cAMP; cyclic AMP; cDNA; complimentary DNA; cGMP; cyclic guanosine monophosphate; ChAT; choline acetalytransferase; CNB; cyclic nucleotide binding site; CNG; cyclic nucleotide gated ch
Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking
Keywords: EEA1; Early endosomal autoantigen 1; FRAP; Fluorescence recovery after photobleaching; GAP; GTPase activating protein; GDI; Guanine nucleotide dissociation inhibitor; GEF; Guanine nucleotide exchange factor; MAPK; Mitogen-activated protein kinase; p85α;
START-GAP1/DLC1 is localized in focal adhesions through interaction with the PTB domain of tensin2
Keywords: DLC; deleted in liver cancer; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; PLC; phospholipase C; FAT; focal adhesion targeting; PKC; protein kinase C; PTB; phosphotyrosine binding; PtdIns(4,5)P2; phosphatidylinositol 4,5-bispho
Vav1: A hematopoietic signal transduction molecule involved in human malignancies
Keywords: Vav1; GEF; Rac; Immunological synapse; NFAT
Rab GTPase function in Golgi trafficking
Keywords: Golgi; GTPase; Rab; GAP; GEF
Molecular basis for the substrate specificity of plant guanine nucleotide exchange factors for ROP
Keywords: At; Arabidopsis thaliana; Cdc42; cell division cycle 42; cDNA; complementary DNA; Dbl; diffuse B-cell lymphoma; DH; Dbl homology; G protein; guanine nucleotide binding protein; GDI; guanine nucleotide dissociation inhibitor; GEF; guanine nucleotide exchan
Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo
Keywords: GABAA receptor; Gephyrin; GEF; Synaptic plasticity; Granule cell
Juvenile hormone regulation of Drosophila Epac—A guanine nucleotide exchange factor
Keywords: Quantitative real-time RT-PCR; Epac; GEF; JH; Methoprene; Methyl farnesoate; Bisepoxy JH III; 20-Hydroxyecdysone
Expression and function of phospholipase C in breast carcinoma
Keywords: Phosphoinositide-specific phospholipase C; (PLC); DMEM; Dulbecco's modified essential media; Foxn1; forkhead transcription factor N1; GDP; guanosine diphosphate; GTP; guanosine triphosphate; GEF; guanine exchange factor; PGK1; phosphoglycerate 1-kinase; P
Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome
Keywords: Autosomal recessive hyper-IgE syndrome; human gene mutation; DOCK8; primary immunodeficiency; molluscum contagiosum; recurrent infection; T cells; TH17 cells; eosinophils; IgE regulation; copy number variations; genomic deletions; AR; Autosomal-recessive;
An Arf1 GTPase mutant with different responses to GEF inhibitors
Keywords: GTPase; Arf; ADP ribosylation factor; Guanine nucleotide exchange factor; GEF; Sec7; ARNO; Protein-protein interactions; Inhibitor; Fluorescence kinetics
Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis
Keywords: P-Rex1; Rac1; GEF; Chemotaxis; Atherosclerosis
Predominant localization of EFA6A, a guanine nucleotide exchange factor for ARF6, at the perisynaptic photoreceptor processes
Keywords: ARF; ADP ribosylation factor; BIG; brefeldin A-inhibited GEF; BRAG; brefeldin A-resistant ARF-GEF; DAB; 3,3'-diaminobenzidine terahydrochloride; EFA6; exchange factor for ARF6; FBS; F-box/Sec7 protein; FBX; F-box only protein; GAP; GTPase-activating prote
The DH-PH Region of the Giant Protein UNC-89 Activates RHO-1 GTPase in Caenorhabditis elegans Body Wall Muscle
Keywords: GEF, guanine nucleotide exchange factor; GAP, GTPase-activating protein; MBP, maltose-binding protein; MHC, myosin heavy chain; GFP, green fluorescent proteinC. elegans; muscle; GEF; rho; UNC-89
The incremental cost principle and the conservation of globally important habitats: A critical examination
Keywords: Incremental cost; GEF; Conservation financing; Habitat protection;
Aspergillus nidulans hypB encodes a Sec7-domain protein important for hyphal morphogenesis
Keywords: ARF; Aspergillus nidulans; GEF; hypB5; Hyphal morphogenesis; COPI; Membrane trafficking; Secretion; Sec7p
Regulation of cardiac excitation and contraction by p21 activated kinase-1
Keywords: Protein phosphatase 2A; L-type Ca2+-channel; Sarcomeric protein phosphorylation; Ryanodine receptor; AC; denylate cyclase; Ad; adenovirus; BK channel; Ca2+-activated K+ currents; B(PR55); PP2A regulatory subunits; Bâ²(PR61); PP2A regulatory subunits; Bâ
The RCC1 superfamily: From genes, to function, to disease
Keywords: RCC1; RLD; GRF; GEF; HERC; RCBTB
PH domain-mediated membrane targeting of Asef
Keywords: APC; Asef; PH domain; GEF; G-protein; E-cadherin
Cocaine increases Ras-guanine nucleotide-releasing factor 1 protein expression in the rat striatum in vivo
Keywords: Ras-GRF2; GEF; CDC25; Stimulant; MAPK; ERK; Caudate; Nucleus accumbens
ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics
Keywords: ALS2CL; ALS2 carboxy-terminal like; MNDs; motor neuron diseases; GEF; guanine-nucleotide exchange factor; RLD; RCC1-like domain; DH; Dbl homology; PH; pleckstrin homology; VPS9; vacuolar protein sorting 9; MORN; membrane occupation and recognition nexus;
Distinct regions of Gα13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs
Keywords: G alpha 12; G alpha 13; G protein; GAP; GEF; RGS protein; RhoA
EhGEF2, a Dbl-RhoGEF from Entamoeba histolytica has atypical biochemical properties and participates in essential cellular processes
Keywords: GEF; guanine nucleotide exchange factor; DH; Dbl homology; PH; Pleckstrin homology; Arm; armadillo; PA; phosphatidic acid; Dbl proteins; Rho GTPases; EhGEF2; Entamoeba histolytica; Armadillo; Phosphatidic acid; Erythrophagocytosis; Proliferation; Chemotax
Impact of live cell imaging on coated vesicle research
Keywords: AP; adaptor protein; BFA; brefeldin A; CCD; charge-coupled device; CCP; clathrin-coated pit; CFP; cyan fluorescent protein; CI-MPR; cation-independent mannose 6-phosphate receptor; CLEM; correlative light and electron microscopy; COP; coat protein complex
Laser microdissection and microarray analysis of the hippocampus of Ras-GRF1 knockout mice reveals gene expression changes affecting signal transduction pathways related to memory and learning
Keywords: Ras-GRF1; microarray; transcriptome; hippocampus; Ras nucleotide exchange; laser capture microdissection; AD; Alzheimer disease; CJD; Creutzfeldt-Jacobs disease; FDR; false discovery rate; GEF; guanine nucleotide exchange factor; GO; gene ontology; HRP; h
Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth
Keywords: Dock; Rac1; Cdc42; GEF; Neurite outgrowth
Functional analysis of RalGPS2, a murine guanine nucleotide exchange factor for RalA GTPase
Keywords: RalGPS2; GEF; RalA; PH domain; Actin
Ras: The stress and the strain
Keywords: ERK; extracellular signal-regulated kinase; GAP; GTPase activating protein; GEF; guanine nucleotide exchange factor; GqPCR; Gq protein-coupled receptor; GSH; glutathione; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; PI3K; phosphoi
Class-1 release factor eRF1 promotes GTP binding by class-2 release factor eRF3
Keywords: GTPase; eRF1; eRF3; PABP; GDPNP; GEF; eukaryotes; translation termination; polypeptide release factors
Recent advances in Ca2+-dependent Ras regulation and cell proliferation
Keywords: Calcium; Ras; Cell proliferation; Cell cycle; GEF; GAP; Rap; GTPase; Cancer
The Montreal Protocol's multilateral fund and sustainable development
Keywords: CO2; carbon dioxide; CFCs; chlorofluorocarbons; GEF; Global Environment Facility; GWP; global warming potential; HAPs; hydrocarbon aerosol propellants; HCFCs; hyrdochlorofluorocarbons; HFCs; hydrofluorocarbons; IPCC; Intergovernmental Panel on Climate Cha
Traffic accidents: Molecular genetic insights into the pathogenesis of the hereditary spastic paraplegias
Keywords: Mitochondria; Transport; Axon; Degeneration; Golgi apparatus; Vesicle trafficking; Myelin; Endocytosis; Motor; Chaperone; BSCL2; Berardinelli-Seip congenital lipodystrophy 2; CGL; congenital generalized lipodystrophy; ER; endoplasmic reticulum; GEF; gua
A bifunctional Gαi/Gαs modulatory peptide that attenuates adenylyl cyclase activity
Keywords: Adenylyl cyclase; Biosensors; G-proteins; Phage display; Signal transduction; Surface plasmon resonance; AC; adenylyl cyclase [E.C. 4.6.1.1]; AMP; adenosine monophosphate; cAMP; cyclic AMP; FITC; fluorescein isothiocyanate; FSK; forskolin; GDI; guanine nu
Entamoeba histolytica: Identification of EhGPCR-1, a novel putative G protein-coupled receptor that binds to EhRabB
Keywords: GDI; GDP-dissociation inhibitor; GEF; guanine exchange factor; GPCRs; G protein-coupled receptors; ORF; open reading frame; SD; synthetic dropout medium; TM; transmembranal; Entamoeba histolytica; EhRabB; GPCRs; Phagocytosis; Rab GTPase;
Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins
Keywords: PI(3)P; phosphatidylinositol-3-monophosphate; PI(4)P; phosphatidylinositol-4-monophosphate; PI(4,5)P2; phosphatidylinositol-4,5-bisphosphate; GEF; guanine nucleotide exchange factor; RLD; RCC1-like domain; RCC1; regulator of chromosome condensation 1; ARF
Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure
Keywords: Integrin; Cdc42; GEF; PAT-3; UNC-112; Signal transduction; Caenorhabditis elegans;
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac
Keywords: ACh; acetylcholine; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease; Aβ; amyloid β-peptide; APP; amyloid precursor protein; sAPPα; soluble form of the amyloid precursor protein; FSK; forskolin; GEF; guanine nucleotide exchange factor
Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes
Keywords: GC; germinal center; BCR; B cell receptor; GEF; guanine nucleotide exchange factor; CDM; CED-5, DOCK180, Myoblast city; CZH; CDM-zizimin homology; GFP; green fluorescence protein; PNA; peanuts agglutinin; PH; pleckstrin homology; GST; glutathione S-transf
Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes
Keywords: TCR; T cell receptor; HIV-1; human immunodeficiency virus type 1; LTR; long terminal repeat; CHO; Chinese hamster ovary; PBS; phosphate-buffered saline; BSA; bovine serum albumin; PI3K; phosphatidylinositol 3â²-kinase; PP1; 4-amino-5-[4-methylphenyl]-7-[
Mastering time and space: immune cell polarization and chemotaxis
Keywords: Arp2/3; actin-related protein; CRAC; cytosolic regulator for adenylyl cyclase; DOCK-2; downstream of Crk-180 homolog-2 protein; ECM; extracellular matrix; ERM; ezrin-radixin-moesin; F-actin; filamentous actin; fMLP; formyl-methionyl-leucyl-phenylalanine;
Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain
Keywords: EST; expressed sequence tag; GEF; guanine exchange factor; PH; pleckstrin domain; Yeast two-hybrid screen; FLJ protein; Alternative splicing; Perinuclear localization;
Signalling pathways regulating the invasive differentiation of human trophoblasts: a review
Keywords: Human trophoblast; Signal transduction; Differentiation; Cell invasion; ALKs; activin-receptor-like kinases; bHLH; basic helix-loop-helix; CaMKII; Ca/calmodulin-dependent kinase II; CTB; cytotrophoblast; eCTB; endovascular cytotrophoblast; ECM; extracellu