Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras
Keywords: Breast cancer; Cell proliferation; GEF; Phospholipase; Ras;
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p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells
Keywords: DH; Dbl homology; FCS; fetal calf serum; GEF; guanine nucleotide exchange factor; GST; glutathione S-transferase; PH; pleckstrin homology; RBD; Rho-binding domain; shRNA; short hairpin RNA; p63RhoGEF; RhoA; Rho-GEF; Cell migration; Lamellipodium; MDA-MB-2
Tiam-1, a GEF for Rac1, plays a critical role in metformin-mediated glucose uptake in C2C12 cells
Keywords: ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxyamide-1-d-robofuranoside; AMPK; AMP-activated protein kinase; GEF; guanine nucleotide exchange factor; Tiam-1; T-lymphoma invasion and metastasis-inducing protein-1; AMPK; GEF; Glucose uptake;
Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein
Keywords: G protein; guanosine triphosphate binding protein; Rho; Rho family small GTPase; GEF; guanine-nucleotide exchange factor; RhoGEF; Rho specific GEF; GPCR; heterotrimeric G protein coupled receptor; PBS; phosphate-buffered saline; FLJ00018; Actin; G protein
Glutathiolated Ras: Characterization and implications for Ras activation
Keywords: BAEC; bovine aortic endothelial cell; DAF; diaminofluorescein; DEANO; diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate; eNOS; endothelial nitric oxide synthase; GAP; GTPase activating protein; GEF; guanine nucleotide exchange factors; HCD;
Rit subfamily small GTPases: Regulators in neuronal differentiation and survival
Keywords: CA; constitutively active; cAMP; cyclic adenosine monophosphate; CaM; calmodulin; CCI; controlled cortical impact; CREB; cAMP response element binding protein; CRIB; Cdc42/Rac interactive binding; DA; dopamine; DAT; dopamine transporter; DN; dominant nega
Rho participates in chemoreceptor-induced changes in morphology to hair bundle mechanoreceptors of the sea anemone, Nematostella vectensis
Keywords: BSA; bovine serum albumin; CN; calcineurin; CaM-kinase; calmodulin-dependent kinase; GDI; GDP dissociation inhibitor; GEF; guanine nucleotide exchange factor; GPCR; G-protein coupled receptors; IP3; inositol 1,4,5-triphosphate; KSW; high potassium seawate
Epac activator critically regulates action potential duration by decreasing potassium current in rat adult ventricle
Keywords: cAMP; cyclic adenosine 3â², 5â²-monophosphate; PKA; cAMP-dependent protein kinase; IK; delayed rectifier potassium current; Epac; exchange proteins directly activated by cAMP; GEF; guanine nucleotide exchange factors; ICa; L-type calcium current; PDE; p
PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively
Keywords: ECM; extracellular matrix; EGF; epidermal growth factor; FGF; fibroblast growth factor; GEF; guanine nucleotide exchange factor; HGF; hepatocyte growth factor; MMP; matrix metalloproteinase; PAK; p21-activated kinase; PI3K; phosphoinositide 3-kinase; PTEN
8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1
Keywords: 8-oxoG; 8-oxo-7,8-dihydroguanine; 8-oxodG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; 8-OH-Ade; 8-oxo-7,8-dihydroadenine; APE1; apurinic/apyrimidinic endonuclease 1; DNA BER; base excision repair; FapyG; 2,6-diamino-4-hydroxy-5-formamidopyrimidine; FU; fluore
The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis
Keywords: BAR; Bin-Amphiphysin-Rvs; Bin; Bridging integrator; CSA; Cross-sectional area; DM; Differentiation media; eMyHC; Embryonic myosin heavy chain; F-actin; Filamentous actin; GAP; GTPase-activating protein; GEF; Guanine nucleotide exchange factor; GM; Growth
Structural and functional analysis of FIP2 binding to the endosome-localised Rab25 GTPase
Keywords: ERC; endosomal-recycling compartment; FIP2; Rab11 family interacting protein 2; GAP; GTPase-activating protein; GDI; GTP/GDP dissociation inhibitor; GEF; guanine nucleotide exchange factor; GTP; guanosine 5â² triphosphate; ITC; isothermal titration calor
LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4
Keywords: F-actin; filamentous actin; G-actin; globular actin; LIMK; LIM domain kinase; LRRK2; leucine-rich repeat kinase 2; PAK; p21 protein (Cdc42/Rac)-activated kinase; qRT-PCR; quantitative reverse transcription polymerase chain reaction; GEF; guanine nucleotid
Beyond symmetry-breaking: competition and negative feedback in GTPase regulation
Keywords: Cdc42; Rac; Rop; GEF; GAP
Ect2, an ortholog of Drosophila Pebble, regulates formation of growth cones in primary cortical neurons
Keywords: GEF; Neuronal development; Cerebral cortex; Growth cones
The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis
Keywords: GPCR; G protein-coupled receptor; GRK; GPCR kinase; GIT; GRK-interacting protein; ARF-GAPs; ADP-ribosylation factor GTPase-activating proteins; GEF; guanine nucleotide exchange factor; MSC; mesenchymal stem cell; qCT; quantitative micro-computed tomograph
cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells
Keywords: NO; nitric oxide; cGK; cGMP-dependent protein kinase; GEF; guanine nucleotide exchange factor; GAP; GTPase-activating protein; 8-pCPT-cGMP; 8-(4-chlorophenylthio)-cGMP; RA; all-trans-retinoic acid; LPA; 1-oleoyl lysophosphatidic acid; VASP; vasodilator-st
Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells
Keywords: GEF; guanine nucleotide exchange factor; GFP; green fluorescent protein; GST; glutathione S-transferase; HA; hemagglutinin; PI3K; phosphoinositide 3 kinase; siRNA; small interfering RNA; TRITC; tetramethylrhodamine isothiocyanate; Glucose uptake; GTPase;
A novel calmodulin-β-PIX interaction and its implication in receptor tyrosine kinase regulation
Keywords: β-PIX; β-p21-activated kinase interacting exchange factor; Ca2 +; calcium; CaM; calmodulin; c-Cbl; casitas B-cell lymphoma; CC; coiled-coil; CD; circular dichroism; DH; diffuse B-cell lymphoma homology; EGFR; epidermal growth factor receptor; GEF; guan
Epac enhances excitation-transcription coupling in cardiac myocytes
Keywords: [Ca2Â +]; calcium concentration; [Ca2Â +]i; intracytoplasmic calcium concentration; [Ca2Â +]n; intranuclear calcium concentration; 2-APB; 2-aminoethoxydiphenyl borate; 8-pCPT; 8-(4-chlorophenylthio)-2-O-methyladenosine-3,5_-cyclic monophosphate; BP; band
Localization of Ras signaling complex in budding yeast
Keywords: cAMP; 3â²-5â²-cyclic adenosine monophosphate; GEF; guanine exchange factor; GAP; GTPase activating protein; ER; endoplasmic reticulum; PKA; protein kinase A; GPCR; G-protein coupled receptor; Saccharomyces cerevisiae; Cdc25; Ira; Adenylate cyclase; Memb
Vav1 in differentiation of tumoral promyelocytes
Keywords: GEF; guanosine exchange factor; APL; acute promyelocytic leukemia; ATRA; All-trans retinoic acid; LIC; leukemia initiating cells; PMA; phorbol 12-myristate 13-acetate; PIP; phosphatidylinositol 4-phosphate; PIP2; phosphatidylinositol 4, 5-bisphosphate; PI
Small GTPases Rap1 and RhoA regulate superoxide formation by Rac1 GTPases activation during the phagocytosis of IgG-opsonized zymosans in macrophages
Keywords: DHE; dihydroethidium; DMEM; Dulbecco's modified Eagle medium; Epac; exchange protein directly activated by cAMP; ERK; extracellular signal-regulated kinases; FBS; fetal bovine serum; FITC; fluorescein isothiocyanate; GAP; GTPase activating proteins; GDI;
Role of phospholipase Cε in physiological phosphoinositide signaling networks
Keywords: PLC; phosphoinositide-specific phospholipase C; PKC; protein kinase C; LPA; lysophosphatidic acid; S1P; sphingosine-1 phosphate; Epac; Exchange protein directly activated by cAMP; GPCR; G protein-coupled receptor; GEF; guanine nucleotide exchange factor;
Regulation of the Golgi complex by phospholipid remodeling enzymes
Keywords: AA; Arachidonic acid; ACAT; acyl-CoA cholesterol acyltransferase; AGPAT; 1-acylglycerol-3-phosphate acyltransferase; Arf; ADP-ribosylating factor; BARS; BFA-inhibited, ADP-ribosylated substrate; BFA; Brefeldin A; CPT1; Choline-phosphotransferase; DAG; Dia
Ras inhibition via direct Ras binding-is there a path forward?
Keywords: ATP; adenosine triphosphate; FTase; farnesyltransferase; FTmap; fourier transform correlation mapping; GAP; GTPase activating protein; GDP; guanosine diphosphate; GEF; guanine-nucleotide exchange factor; GST; glutathione s-transferase; GTP; guanosine trip
RhoA and Rho kinase mediate cyclosporine A and sirolimus-induced barrier tightening in renal proximal tubular cells
Keywords: CsA; cyclosporine A (CsA); GEF; GDP-GTP exchange factor; NR; non-related; RBD; Rho binding domain; ROK; Rho kinase; SRL; sirolimus; TER; transepithelial resistance; TJ; tight junction; VC; vehicle control; Transepithelial resistance; Tight junctions; Im
Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners
Keywords: AMPK; AMP-activated protein kinase; ARF; ADP-ribosylation factor; CDK5; cyclin-dependent kinase 5; CEM; caveolin-enriched membrane; CRMP-2; collapsin response mediator protein-2; EGF; epidermal growth factor; EGFR; EGF receptor; GAP; GTPase-activating pro
Identification and structural basis for a novel interaction between Vav2 and Arap3
Keywords: GEF; guanine nucleotide exchange factor; GAP; GTPase-activating protein; SH2; Src homology 2; pY; phosphotyrosine; PV; pervanadate; MD; molecular dynamics; Vav2; Arap3; SH2 domain; NMR; Protein-peptide interaction; Complex structure;
The ribosome modulates the structural dynamics of the conserved GTPase HflX and triggers tight nucleotide binding
Keywords: HflX; Nucleotide binding; Ribosome; Limited trypsinolysis; GTPase-activated state; Stopped-flow; P-loop; phosphate-binding loop; GEF; guanine nucleotide exchange factor; GAP; GTPase activating protein; GDI; guanine nucleotide dissociation inhibitor; EF; e
Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation
Keywords: CRC; colorectal cancer; APC; Adenomatous Polyposis Coli; GEF; guanine nucleotide exchange factor; GAP; GTPase activating protein; NL; non-linear; EBI; European Bioinformatics Institute; XCorr; cross-correlation number; DelCn; Delta correlation number; BCA
A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei
Keywords: Arf; ADP-ribosylation factor; Arl; ADP-ribosylation factor-like; Arl6ip; Arl6 interacting protein; BBS; Bardet-Biedl syndrome; BBS1; Bardet-Biedl syndrome 1 protein; BSF; bloodstream form; ConA; Concanavalin A; GEF; guanine nucleotide exchange factor;
Interaction of activated Rab5 with actin-bundling proteins, L- and T-plastin and its relevance to endocytic functions in mammalian cells
Keywords: GAPs; GTPase-activating proteins; GEF; guanine nucleotide-exchange factors; GDI; GDP dissociation inhibitors; LC-MS/MS; liquid chromatography-mass spectrometry/mass spectrometry; R5BD; Rab5 binding domain; Rab5; L-plastin; T-plastin; Endocytosis;
Rho GTPases and exocytosis: What are the molecular links?
Keywords: Arp; actin related protein; GAP; GTPase activating protein; GDI; guanosine nucleotide dissociation inhibitor; GEF; guanosine nucleotide exchange factor; GTPase; guanosine triphosphatase; MMPs; metalloproteinases; PA; phosphatidic acid; PI4K; phosphatidyl
ALS pathogenesis: Recent insights from genetics and mouse models
Keywords: ALS; amyotrophic lateral sclerosis; ER; endoplasmic reticulum; FTLD-U; frontotemporal lobar dementia with ubiquitinated inclusions; FUS; fused in sarcoma; GEF; guanine nucleotide exchange factor; IAHSP; infantile ascending hereditary spastic paralysis; IF
Models for the functions of Arf GAPs
Keywords: Arf; ADP-ribosylation factor; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; ER; endoplasmic reticulum; ERGIC; endoplasmic reticulum-Golgi intermediate compartment; SNARE; soluble N-ethylmaleimide-sensitive factor attachment prot
Renewable energy policies and initiatives for a sustainable energy future in Malaysia
Keywords: RE; renewable energy; SREP; small renewable energy power programme; 8MP; Eighth Malaysia Plan; BioGen; biomass generation and demonstration project; GoM; Government of Malaysia; 9MP; Ninth Malaysia Plan; MBIPV; Malaysia building integrated photovoltaic; C
Institutional design for improved forest governance through REDD: Lessons from the global environment facility
Keywords: REDD; Legitimacy; Biodiversity; Climate change; GEF; Governance;
Rho GTPases as regulators of morphological neuroplasticity
Keywords: C3; Clostridium botulinum ribosyltransferase; cAMP; cyclic adenosine monophosphate; Cdc42; cell division control protein 42 homolog; CRIB; Cdc42/Rac interactive binding; DRG; dorsal root ganglia; ERK; extracellular signal-regulated kinase; FAK; focal adhe
Research ArticleInactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer
Keywords: AIP1; ASK1-interacting protein 1; ASK1; apoptosis signal-regulating kinase 1; CAPRI; Ca2+-promoted Ras inactivator; DAB2IP; disabled homolog 2 interacting protein; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; HCC; hepatocellula
New links between vesicle coats and Rab-mediated vesicle targeting
Keywords: AP; adaptor protein complex; CCV; clathrin-coated vesicle; COG; conserved oligomeric Golgi; COP; coat protein complex; GAP; GTPase activating protein; GEF; guanine nucleotide exchange factor; HOPS; homotypic fusion and vacuole protein sorting; hRME-6; hum
Rho proteins of plants – Functional cycle and regulation of cytoskeletal dynamics
Keywords: Plant; Cytoskeleton; Actin; Microtubules; Rho; ROP; GEF; GAP; Effector; Polar growth
Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers
Keywords: Cdc42; cell division cycle 42; GEF; Guanine nucleotide exchange factor; GPCR; G-protein coupled receptor; LFA-1; Leukocyte function-associated antigen-1; LTB4; leukotriene B4; PAF; platelet activating factor; PI3K; Phosphatidylinositol 3-kinase; PIP2; pho
The 1.9Â Ã
crystal structure of Prp20p from Saccharomyces cerevisiae and its binding properties to Gsp1p and histones
Keywords: RCC1; regulator of chromosome condensation 1; GEF; guanine nucleotide exchange factor; GAP; GTPase-activating protein; NLS; nuclear localization signal; RLD; RCC1-like domain; MD; molecular dynamics; NPC; nuclear pore complex; BA; boundary activity; GST;
Hippocampal phenotypes in kalirin-deficient mice
Keywords: GEF; Synaptic plasticity; Dendrite; Dendritic spine; Rac1; Knockout; Fear conditioning;
Synthetic biosensing systems
Keywords: RBS; ribosome binding site; GPCR; G protein coupled receptor; RTK; receptor tyrosine kinase; MAPK; mitogen-activated protein kinase; GDP; guanosine diphosphate; GTP; guanosine triphosphate; GEF; guanine nucleotide exchange factor; GAP; GTPase activating p
Unique sequences and predicted functions of myosins in Tetrahymena thermophila
Keywords: ATP; adenosine 5â²-triphosphate; GAP; guanosine 5â²-triphosphatase-activating protein; GDP; guanosine 5â²-diphosphate; GTP; guanosine 5â²-triphosphate; F-actin; filamentous actin; FERM; band 4.1/ezrin/radixin/moesin; GEF; guanine nucleotide exchange f
Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy?
Keywords: Vav1; Cytoskeleton; Rac; GEF; RhoGTPases
swap70 Promotes neural precursor cell cycle exit and oligodendrocyte formation
Keywords: CNS; central nervous system; OPCs; oligodendrocyte progenitor cells; GEF; guanine nucleotide exchange factor; PIP3; phosphatidylinositol-3,4,5-triphosphate; Neural precursor; Oligodendrocyte; Glia; Zebrafish; Neurogenesis;
Rab GTPases implicated in inherited and acquired disorders
Keywords: ER; endoplasmic reticulum; EEA; early endosome antigen; GDP; guanosine diphosphate; GDI; GDP dissociation inhibitor; GEF; guanine exchange factor; GAP; GTPase activating protein; GLUT4; glucose transporter 4; GTP; guanosine triphosphate; MAPK; mitogen act