دانلود مقالات ISI درباره Gsis + ترجمه فارسی

The bile acid TUDCA increases glucose-induced insulin secretion via the cAMP/PKA pathway in pancreatic beta cells

Keywords: 6E-CDCA; 6-Ethyl-chedeoxycholic acid; ADP; Adenosine diphosphate; AKT or PTB; Protein kinase B; ATP; Adenosine triphosphate; AUC; Area under curve; BSA; Bovine serum albumin; cAMP; Cyclic adenosine monophosphate; CREB; cAMP response element-binding protei

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Efficient generation of pancreatic β-like cells from the mouse gallbladder

Keywords: GBCs; gallbladder cells; rGBC1; 1st generation reprogrammed islet-like cells; rGBC2; 2nd generation reprogrammed β-like cells; GSIS; glucose-stimulated insulin secretion; FACS; fluorescence-activated cell sorting; Gallbladder; Type 1 diabetes; Pancreatic

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Disrupted dynamics of F-actin and insulin granule fusion in INS-1 832/13 beta-cells exposed to glucotoxicity: partial restoration by glucagon-like peptide 1

Keywords: C; Control; EGFP; Enhanced Green Fluorescent protein; ESI-05; 4-Methylphenyl-2, 4, 6-trimethylphenylsulfone; F-actin; Filamentous Actin; GLP-1; Glucagon-like peptide 1; GSIS; Glucose-stimulated insulin secretion; HG; High-glucose; NPY; Neuropeptide Y; RFP

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells

Keywords: NA; nicotinic acid; BHB; β-hydroxybutyrate; FFAs; free fatty acids; cAMP; cyclic adenosine monophosphate; GSIS; glucose stimulated insulin secretion; PTX; pertussis toxin; IBMX; 3-isobutyl-1-methylxanthine; DAB; 3,3′-diaminobenzidine; DAPI; 4',6-diam

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic β Cells during Fasting and in Type 2 Diabetes

Keywords: ACC; acetyl CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; AIR; acute insulin response; AMPK; AMP-activated protein kinase; CT; computed tomography; 2-DG; 2-deoxy-d-glucose; 18F-FDG; 2-[fluorine-18]-2-deoxy-d-glucose; GIP; g

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells

Keywords: 4E-BP1; 4E binding protein; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; ATP; adenosine triphosphate; DEPTOR; DEP domain containing mTOR-interacting protein; CI; complexes I; CII; complex II; CIII; complex III; CIV; complex

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

Type II PKAs are anchored to mature insulin secretory granules in INS-1 β-cells and required for cAMP-dependent potentiation of exocytosis

Keywords: Pancreatic; Endocrine; Insulin; Exocytosis; Potentiation; Protein kinase-A; cAMP; Compartmentalization; AKAP; A-Kinase anchoring protein; Epac; Exchange proteins directly activated by cAMP; GEF; Guanine nucleotide exchange factor; GLP-1; Glucagon-like pep

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response

Keywords: FBS; fetal bovine serum; FFA; free fatty acids; FFAR1; free fatty acid receptor 1; GSIS; glucose-stimulated insulin secretion; SFA; saturated FFA; USFA; unsaturated FFA; OCR; oxygen consumption rate; MS; mass spectrometry; Palmitate; Oleate; Insulin secre

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Glucagon-like peptide-1 improves beta-cell antioxidant capacity via extracellular regulated kinases pathway and Nrf2 translocation

Keywords: DCFH; dichorofluorescin; GLP-1; glucagon-like peptide-1; GPx; glutathione peroxidase; GR; glutathione reductase; GSIS; glucose-stimulated insulin secretion; GSH; reduced glutathione; Nrf2; nuclear transcription factor erythroid 2p45-related factor; ROS; r

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2016 سفارش ترجمه

Dietary vitamin D3 improves postprandial hyperglycemia in aged mice

Keywords: Vitamin D3; Insulin secretion; Postprandial hyperglycemia; GLP-1; GSIS; glucose stimulated insulin secretion; RT-PCR; reverse transcription-polymerase chain reaction; OGTT; oral glucose tolerance test; VDR; vitamin D3 receptor; 1,25(OH)2D3; 1-25 dihydroxy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models

Keywords: Yhhu4488; GPR40; Type 2 diabetes mellitus; Glucagon-like peptide-1; Insulin; DPP IV; dipeptidyl peptidase IV; FRIC; fetal rat intestinal cells; GLP-1; glucagon-like peptide-1; GPR40; G protein-coupled receptor 40; GSIS; glucose-stimulated insulin secretio

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Uncoupling protein-2 attenuates palmitoleate protection against the cytotoxic production of mitochondrial reactive oxygen species in INS-1E insulinoma cells

Keywords: Pancreatic beta cells; Glucolipotoxicity; Cytoprotection; Mitochondrial dysfunction; Uncoupling protein-2 (UCP2); Reactive oxygen species; INS-1E insulinoma cells; Non-esterified fatty acids; Obesity; Type 2 diabetes; BSA; bovine serum albumin; DAPI; 4′

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis

Keywords: GLP-1; GSIS; Pancreatic β-cells; TCF7L2; TCF7L2DN; Wnt; Incretin receptors

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells

Keywords: Arf6; ADP-ribosylation factor 6; Cdc42; Cell division control protein 42; ERK1/2; Extracellular signal-regulated kinases; GEF; Guanine nucleotide exchange factor; GDP; Guanosine diphosphate; GTP; Guanosine triphosphate; GGTI; Geranylgeranyl transferase in

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Developmental exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin attenuates later-life Notch1-mediated T cell development and leukemogenesis

Keywords: AHR; aryl hydrocarbon receptor; GSIs; gamma-secretase inhibitors; GD; gestational day; ICN; intracellular Notch; MFI; mean fluorescence intensity; PPD; post-partum day; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; 2,3,7,8-tetrachlorodibenzo-p-dioxin; Develo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic β-cell insulin secretion

Keywords: Glutathione; Redox; Insulin secretion; Mitochondria; Pancreatic beta-cell; Grx1; Glutaredoxin-1; GSIS; Glucose-stimulated insulin secretion; roGFP; Reduction-oxidation sensitive green fluorescent protein; ROS; Reactive oxygen species; GSH; reduced glutath

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2015 سفارش ترجمه

Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways

Keywords: AKT/PKB; protein kinase B; DCF; dichorofluorescein; DHBA; 2,3-dihydroxybenzoic acid; DHPAA; 3,4-dihydroxyphenylacetic acid; ERK; extra cellular regulated kinase; GSIS; glucose-stimulated insulin secretion; HPPA; 3-hydroxyphenylpropionic acid; KRB; Krebsâ€

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Acute exposure of beta-cells to troglitazone decreases insulin hypersecretion via activating AMPK

Keywords: AMPK; AMP-activated protein kinase; TZD; thiazolidinediones; IGT; impaired glucose tolerance; IFG; impaired fasting glucose; GSIS; glucose-stimulated insulin secretion; ACC; acetyl-CoA carboxylase; PPARγ; peroxisome proliferator-activated receptor γ; sh

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor

Keywords: PPARβ/δ; peroxisome proliferator-activated receptor β/δ; GLP-1R; glucagon-like peptide-1 receptor; GW; GW501516; PA; palmitate; qPCR; quantitative polymerase chain reaction; SREBP-1c; sterol regulatory element binding protein-1c; GSIS; glucose-stimula

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus

Keywords: Type 2 diabetes mellitus (T2DM); Glucokinase activator (GKA); GK; glucokinase; GKA; glucokinase activator; SU; sulfonylurea; DPP-4; dipeptidyl peptidase-4; TZD; thiazolidinedione; SGLT2; sodium-glucose co-transporter 2; GSIS; glucose-stimulated insulin se

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells

Keywords: FFAR1; free fatty acid receptor 1; FFAs; free fatty acids; PIO; pioglitazone; PA; palmitic acid; ROS; reactive oxygen specific; PLCγ; Phospholipase C γ; ERK1/2; extracellular signal-regulated kinase 1/2; PPARγ; peroxisome proliferator activated recepto

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: Has it been overlooked?

Keywords: AAT; aspartate aminotransferase; ANT; adenine nucleotide transporter; Asp; aspartate; Asp/Glu; aspartate glutamate transporter; αKG; alpha-ketoglutarate; αKGT; alpha-ketoglutarate transporter; CIC; citrate isocitrate transporter; cytAAT; cytosolic aspar

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2014 سفارش ترجمه

The orphan nuclear receptor small heterodimer partner negatively regulates pancreatic beta cell survival and hyperglycemia in multiple low-dose streptozotocin-induced type 1 diabetic mice

Keywords: GSIS; glucose-stimulated insulin secretion; PDX-1; pancreatic duodenal homeobox factor 1; SHP; small heterodimer partner; STZ; streptozotocin; Small heterodimer partner; Streptozotocin; Diabetes; Beta cell apoptosis; Insulin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming

Keywords: PSCs; pluripotent stem cells; GBC; gall bladder cell; RA; retinoic acid; DBZ; dibenzazepine; GSIS; glucose-stimulated insulin secretion; qPCR; quantitative PCR; RT-PCR; reverse transcription PCR; FACS; fluorescence-activated cell sorting;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

PPARs: Fatty acid sensors controlling metabolism

Keywords: AF; activation function; AMPK; AMP-activated protein kinase; BAT; brown adipose tissue; C/EBPα; CCAAT-enhancer binding protein α; DBD; DNA binding domain; FA; fatty acid; FAO; FA oxidation; HAT; histone acetyl transferase; HFD; high fat diet; GSIS; gluc

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage

Keywords: 18S; 18S ribosomal RNA; ARE; antioxidant response element; DMA3 +; dimethylarsinous acid; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; GCLC; γ-glutamate cysteine ligase catalytic subunit; GSIS; glucose-stimulated insulin secretion;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes

Keywords: T2D; type 2 diabetes; GSIS; glucose-stimulated insulin secretion; SNP; polymorphism; DGI; diabetes Genetic Initiative; BIS; basal insulin secretion; Type 2 diabetes; Islet; Beta-cell; Exocytosis; SYT; GWAS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction

Keywords: FFA; free fatty acid; PDX1; pancreatic and duodenal homeobox 1; GSIS; glucose-stimulated insulin secretion; JNK; Jun N-terminal kinase; SIRT1; sirtuin 1; PGC-1; peroxisome proliferator-activated receptor gamma coactivator 1; NeuroD; neurogenic differentia

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Role of phospholipase Cε in physiological phosphoinositide signaling networks

Keywords: PLC; phosphoinositide-specific phospholipase C; PKC; protein kinase C; LPA; lysophosphatidic acid; S1P; sphingosine-1 phosphate; Epac; Exchange protein directly activated by cAMP; GPCR; G protein-coupled receptor; GEF; guanine nucleotide exchange factor;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes

Keywords: Insulin secretion; Glycerolipid/fatty acid cycle; Glucolipotoxicity; Lipogenesis; Lipolysis; ABHD6; α/β-domain containing hydrolase-6; ADRP; adipocyte differentiation-related protein; AGPAT; 1-acyl-sn-glycerol-3-phosphate acyltransferase; AMPK; AMP acti

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

The Zinc Finger Protein ZBTB20 Regulates Transcription of Fructose-1,6-Bisphosphatase 1 and β Cell Function in Mice

Keywords: Pancreas; Mouse Model; RIP-Cre; Repressor; ChIP; chromatin immunoprecipitation; FBPase; fructose-1,6-bisphosphatase; G-6-P; glucose-6-phosphate; Gk; glucokinase; GSIS; glucose-stimulated insulin secretion; PFK; phosphofructokinase; RT-PCR; reverse-transcr

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Suppression of FAT/CD36 mRNA by human growth hormone in pancreatic β-cells

Keywords: CA; constitutively active; DN; dominant negative; FA; fatty acid; GSIS; glucose-stimulated insulin secretion; FATP; fatty acid transport protein; FABP; fatty acid binding protein; FASN; fatty acid synthase; FAT; fatty acid translocase; GFP; green fluoresc

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: Implications for understanding genetic association signals at this locus

Keywords: FACs; fluorescence activated cell sorting; FPG; fasting plasma glucose; SNP; single nucleotide polymorphism; GSIS; glucose stimulated insulin secretion; Human genetics; Diabetes; Human islets; Pancreatic beta-cells; GWAS signal translation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Differences in islet-enriched miRNAs in healthy and glucose intolerant human subjects

Keywords: miRNA; microRNA; GSIS; glucose-stimulated insulin secretion; KRB buffer; Krebs Ringer bicarbonate buffer; Human; Pancreatic islet; β-Cell; miRNA; Insulin secretion; Diabetes;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Sauchinone protects pancreatic β cells against cytokine-mediated toxicity

Keywords: Sauchinone; Pancreatic β-cell; Cytokines; Cytoprotection; NF-κB; GSIS;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

Keywords: ∆ψ; mitochondrial membrane potential; DAPI; 4′,6-diamidino-2-phenylindole; DHE; hydroethidine; FCS; fetal calf serum; FCCP; carbonyl cyanide p-trifluoromethoxyphenylhydrazone; GSIS; glucose-stimulated insulin secretion; KRH; Hepes-buffered Krebs-Ri

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice

Keywords: GPR119; G protein-coupled receptor 119; GSIS; glucose-stimulated insulin secretion; T2DM; type 2 diabetes mellitus; SU; sulfonylurea; GPCR; G protein-coupled receptor; GLP-1; glucagon-like peptide-1; HEK; human embryonic kidney; LPC; lysophosphatidylcholi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells

Keywords: MicroRNA; GSIS; Insulin secretion; MIN6 cells

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity

Keywords: BA; bile acids; BSA; bovine serum albumin; FGF; fibroblast growth factor; GSCN; guanidinium thiocyanate; FXR; farnesoid X receptor; GSIS; glucose-stimulated insulin secretion; IAPP; islet amyloid polypeptide; IPGTT; intraperitoneal glucose tolerance test;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Site location analysis for small hydropower using geo-spatial information system

Keywords: Small hydropower; Location analysis; GSIS; Energy; Resources survey

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Glucolipotoxicity in INS-1E cells is counteracted by carnitine palmitoyltransferase 1 over-expression

Keywords: Type 2 diabetes; Glucolipotoxicity; INS-1E; Palmitate; Carnitine palmitoyltransferase 1; ER-stress; GSIS; Apoptosis; p-eIF2α; CHOP/GADD153

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

A chemical chaperone 4-PBA ameliorates palmitate-induced inhibition of glucose-stimulated insulin secretion (GSIS)

Keywords: Chemical chaperone; ER stress; Free fatty acid; GSIS; Palmitate

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells

Keywords: ANT; adenine nucleotide translocase; GSIS; glucose-stimulated insulin secretion; FCS; fetal calf serum; Q; glutamine; ROS; reactive oxygen species; UCP; uncoupling protein; rUCP2; recombinant UCP2; Glutamine; Half-life; Mitochondria; Pancreatic beta-cell;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

The intravenous glucose tolerance test in cannulated Wistar rats: A robust method for the in vivo assessment of glucose-stimulated insulin secretion

Keywords: GSIS; IVGTT; Methods; Wistar rat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

The Development and Initial Validation of the Geriatric Suicide Ideation Scale

Keywords: Suicide ideation; suicide; GSIS; older adults; assessment;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه