The electro-oxidation of water and alcohols at BDD in hexafluoroisopropanol
Keywords: Boron doped diamond; Nonaqueous electrolyte; HFIP; Rotating ring disc electrode;
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Stability of early-stage amyloid-β(1-42) aggregation species
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β protein; GuHCl; guanidine hydrochloride; HFIP; hexafluoroisopropanol; SDS; sodium dodecyl sulfate; SEC; size exclusion chromatography; ThT; thioflavin T; Amyloid-beta protein; Aggregation; Fibrillar oligomer;
Proanthocyanidins are the major anti-diabetic components of cinnamon water extract
Keywords: CD; circular dichroism; CWE; cinnamon water extract; EGCG; (â)-epigallocatechin 3-gallate; HFIP; hexafluoroisopropanol; hIAPP; human islet amyloid polypeptide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PA; proanthocyanidins; PBS
Membrane thickness and the mechanism of action of the short peptaibol trichogin GA IV
Keywords: HFIP; 1,1,1,3,3,3-hexafluoroisopropanol; Aib; α-aminoisobutyric acid; Alm; alamethicin; AMP; antimicrobial peptide; CF; carboxyfluorescein; DIEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; EDC; N-ethyl, Nâ²-[3-(dimethylamino)propyl]carbodiim
Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric β-amyloid 1-42-induced neurotoxicity
Keywords: AD; Alzheimer's disease; Aβ; β-amyloid peptide; APP; amyloid precursor protein; SPs; senile plaques; NFTs; neurofibrillary tangles; ROS; reactive oxygen species; COSs; chitosan oligosaccharides; Aβ42; β-amyloid fragments 1-42; HFIP; 1,1,1,3,3,3-hexafl
Basic NeuroscienceShort communicationA novel approach for Aβ1-40 quantification using immuno-PCR
Keywords: AD; Alzheimer's disease; Aβ; amyloid β-peptide; IPCR; immuno-PCR; HFIP; 1,1,1,3,3,3-hexafluoro-2-propanol; TBS; Tris-buffered saline; TBST; TBS containing 0.05% Tween-20; Ct; threshold cycle; RIPA buffer; radio-immunoprecipitation assay buffer; CA1; cor
Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide
Keywords: CD; circular dichroism; EGCG; (â)-epigallocatechin 3-gallate; HFIP; hexafluoroisopropanol; hIAPP; human islet amyloid polypeptide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; T2DM; type 2 diabetes mellitus; TEM; transmission elect
Peptide-based electrochemical biosensor for amyloid β 1-42 soluble oligomer assay
Keywords: ET; electron transfer; Aβ 1-42; amyloid β 1-42; SAM; self-assembly monolayer; MUA; 11-mercaptoundecanoic acid; Fc; Ferrocene; HFIP; 1,1,1,3,3,3-hexafluoro-2-propanol; TCEP; Tris(2-carboxyethyl) phosphine hydrochloride; MNH; 9-mercapto-1-nonanol; DMS
Biophysical studies with AICD-47 reveal unique binding behavior characteristic of an unfolded domain
Keywords: APP; amyloid precursor's protein; AICD; APP-intracellular C-terminal domain; AD; Alzheimer's disease; SH2; Src homology 2; PTR and pY; phosphorylated tyrosine; IUD; intrinsically unstructured domain; Grb2; growth factor receptor binding protein 2, TFE
The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia
Keywords: LPS; lipopolysaccharide; MLA; methyllycaconitine; MAPK; mitogenâactivated protein kinase; nAChR; nicotinic acetylcholine receptor; PAM; positive allosteric modulator; HFIP; 1,1,1,3,3,3âhexafluoroâ2âpropanol; Nicotinic acetylcholine receptor; Infla
Inhibitory effect of curcumin on the Al(III)-induced Aβ42 aggregation and neurotoxicity in vitro
Keywords: AD; Alzheimer's disease; Aβ42; amyloid-β 42; Al(III); Aluminum ion; CD; circular dichroism; ThT; thioflavin T; AFM; atomic force microscopy; HFIP; hexafluoroisopropanol; CBB; Coomassie Brilliant Blue; A595; absorption at wavelength of 595 nm; Alzheimer
Porphyrins in bio-inspired transformations: Light-harvesting to solar cell
Keywords: BDP; boron dipyrrin; CDCA; chenodeoxycholic acid; CIGS; copper indium gallium selenide; CNT; carbon nanotube; CS; charge seperation; C60; fullerene-C60; D-A; donar-acceptor; DSSC; dye-sensitized solar cell; EET; excited electron transfer; GO; graphene
'Click peptide' using production of monomer Aβ from the O-acyl isopeptide: Application to assay system of aggregation inhibitors and cellular cytotoxicity
Keywords: Aggregation; Amyloid; Alzheimer; Click peptide; Inhibitor; Isopeptide; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; HFIP; 1,1,1,3,3,3-hexafluoro-2-propanol; Myr; myricetin; NDGA; nordihydroguaiaretic acid; Rif; rifampicin; TFA;
Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers
Keywords: Aβ; beta-amyloid; AD; Alzheimer's disease; HSA; human serum albumin; BBB; blood-brain barrier; HPLC; high-performance liquid chromatography; MALDI-TOF; matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; HFIP; hexafluoroisop
Purified high molecular weight synthetic Aβ(1-42) and biological Aβ oligomers are equipotent in rapidly inducing MTT formazan exocytosis
Keywords: APP; amyloid precursor protein; ELISA; enzyme-linked immunoassay; FBS; fetal bovine serum; HFIP; 1,1,1,3,3,3-hexafluoroisopropanol; HRP; horseradish peroxidase; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; H4 neuroglioma; C2C12 myobl
Specificity and sensitivity of the Abeta oligomer ELISA
Keywords: BSA; bovine serum albumin; ELISA; enzyme-linked immunosorbent assay; HFIP; hexafluoro-2-propanol; LMW; low molecular weight; OD; optical density; PBS; phosphate buffered saline; PBS-T; PBS with 0.05% Tween-20; SEM; standard error of the mean; TFA; trifl
L-selectin transmembrane and cytoplasmic domains are monomeric in membranes
Keywords: CAT; chloramphenicol acetyl transferase; CD; circular dichroism; DPC; dodecylphosphocholine; FRET; fluorescence resonance energy transfer; GST; glutathione S-transferase; HFIP; hexafluoroisopropanol; HPLC; high performance liquid chromatography; PSGL-1; P
Porcine islet amyloid polypeptide fragments are refractory to amyloid formation
Keywords: CD; circular dichroism; HFIP; hexafluoroisopropanol; IAPP; islet amyloid polypeptide; MTT; 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; SEC; size-exclusion chromatography; SPPS; solid phase peptide synthesis; T2DM; type 2 diabetes mellitu
Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death
Keywords: AD; Alzheimer's disease; Aβ; beta-amyloid; APP; amyloid-precursor protein; CTF; C-terminal fragment of APP; sAPP; soluble APP; BACE; beta-site of APP cleaving enzyme; DHA; docosahezaenoic acid; PUFA; polyunsaturated fatty acid; ELISA; enzyme linked imm
Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity
Keywords: AD; Alzheimer's diseases; APP; amyloid precursor protein; Aβ; amyloid-β peptide; ACSF; artificial cerebral spinal fluid; BCA; bicinchoninic acid; CF; 5-carboxyfluorescein; DBU; 1,8-diazabicyclo[5,4,0]-undec-7-ene; DCF; dichlorofluorescein diacetate; DIV
Simple assay of plasma sevoflurane and its metabolite hexafluoroisopropanol by headspace GC–MS
Keywords: Sevoflurane; HFIP; Headspace gas chromatography; Mass spectroscopy; Pharmacokinetic study; Anesthetic conserving device
NMR structure of the transmembrane domain of the n-acetylcholine receptor β2 subunit
Keywords: Nicotinic acetylcholine receptor; nAChR; NMR; HFIP; Ion channel structure; Cys-loop structure
Separation of fluorinated amino acids and oligopeptides from their non-fluorinated counterparts using high-performance liquid chromatography
Keywords: Cys; cysteine; DCM; dichloromethane; DIC; N,Nâ²-diisopropylcarbodiimide; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; EtOH; ethanol; F%wt; fluorine weight percentage in an analyte or a solvent; Fmoc; fluorenylmethoxycarbonyl; HFIP; hexaf
Dunaliella salina extract effect on diabetic rats: Metabolic fingerprinting and target metabolite analysis
Keywords: ANOVA; analysis of variance; BGE; background electrolyte; CE; capillary electrophoresis; EDTA; ethylene diamino tetra acetic; GSH; reduced glutathione; GSSG; oxidized glutathione; HFIP; hexafluoroisopropanol; LV; latent variable; PCA; principal component
Structure of hexafluoroisopropanol–water mixture studied by FTIR-ATR spectra and selected chemometric methods
Keywords: 1,1,1,3,3,3-Hexafluoro-2-propanol; HFIP; Multivariate curve resolution; MCR-ALS; Two-dimensional correlation spectroscopy; 2DCOS
Potential pathogenic role of β-amyloid1-42-aluminum complex in Alzheimer's disease
Keywords: AD; Alzheimer's disease; Aβ; β-amyloid; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; DPH; 1,6-diphenyl-1,3,5-hexatriene; TMA-DPH; N,N,N-trimethyl-4-(6-phenyl-1,3,5-hexatrien-1-yl) phenylammonium p-toluenesulfonate; ETASS; electroth
Advances in the Baylis-Hillman reaction-assisted synthesis of cyclic frameworks
Keywords: Baylis-Hillman reaction; Cyclic compounds; Heterocycles; Nucleophilic substitution; Ac; acetyl; AIBN; 2,20-azobisisobutyronitrile; Aq; aqueous; Ar; aryl; 9BBN; 9-borabicyclo[3.3.1]nonane; BINAP; 2,20-bis(diphenylphosphanyl)-1,10-binaphthyl; BF3·Et2O; b
Solid-phase synthesis of backbone-cyclized β-helical peptides
Keywords: Alkanesulfonamide; Safety-catch linker; Cyclic peptide; Solid-phase peptide synthesis; β-Hairpin; β-Turn; β-Helix; HPLC; Gel-permeation chromatography; AS-SLC; alkanesulfonamide safety-catch linker; CBC; cleavage-by-cyclization; Boc; t-butoxycarbonyl;
Separation and quantification of a novel two-component vaccine adjuvant
Keywords: AUC; area under the curve; HFIP; hexafluoroisopropanol; IC31; two-component adjuvant comprising KLK and ODN1a; IEX; ion exchange; IU; international units; KLK; 11-mer cationic peptide; component of IC31; MALDI-TOF; matrix-assisted laser desorption ionisat
Conformational polymorphism, stability and aggregation in spider dragline silks proteins
Keywords: c.m.c.; critical micelle concentration; DOTAC; dodecyltrimethylammonium chloride; EtOH; ethanol; HFIP; hexafluoroisopropanol; IsoP; isopropanol; MeOH; methanol; SRCD; synchrotron radiation circular dichroism; TFE; trifluoroisopropanol; Silk aggregation; H
Characterization and quantification of Bcl-2 antisense G3139 and metabolites in plasma and urine by ion-pair reversed phase HPLC coupled with electrospray ion-trap mass spectrometry
Keywords: HFIP; 1,1,1,3,3,3-hexafluoro-2-propanol; CVs; coefficients of variations; CID; collision induced dissociation; CIVI; continuous intravenous infusion; ESI; electrospray ionisation; ELISA; enzyme-linked immunosorbent assay; IP-RP-HPLC; ion-pair reversed pha
Recent developments in the Nazarov process
Keywords: Nazarov cyclisation; Divinyl ketone; Electrocyclisation; Cyclopentenone; Ar; aryl; BF3·Et2O; boron trifluoride etherate; Boc; tert-butoxycarbonyl; Bu; butyl; Cbz; benzyloxycarbonyl; Chx; cyclohexyl; Cp; cyclopentadienyl; DIB; o-diiodobenzene; Dppe; bis(d