دانلود مقالات ISI درباره Hts + ترجمه فارسی

AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization

Keywords: [Ca2+]i; intracellular Ca2+ concentration; CDZ; chlordiazepoxide; 95% CI; 95-percent confidence interval (as obtained with best-curve fitting); FLIPR; Fluorescence Imaging Plate Reader™ (assay); GABAB; gamma-amino butyric acid receptor, subtype B; l-Glu

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F

Keywords: GlcNAc; N-acetyl glucosamine; HTS; high-throughput screening; MIC; minimum inhibitory concentration; MRSA; methicillin-resistant Staphylococcus aureus; MurNAc; N-acetyl muramic acid; PRSP; penicillin-resistant Streptococcus pneumoniae; (Q)SAR; (quantitati

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2014 سفارش ترجمه

Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: Identification of novel peptidic inhibitors

Keywords: FAM; carboxyfluorescein; FP; fluorescence polarization; HBTU; O-(1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate; HOBt; 1-hydroxy-1H-benzotriazole; MDM2; mouse double minute 2 homolog; MDMX; mouse double minute X homolog; TAMRA;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

PCR amplification and high throughput sequencing of immunoglobulin heavy chain genes from formalin-fixed paraffin-embedded human biopsies

Keywords: FFPE tissues; formalin-fixed paraffin-embedded tissues; HTS; high throughput sequencing; Ig; immunoglobulin; MID; multiplex identifier; SHM; somatic hypermutation; Formalin-fixed paraffin-embedded tissues; High throughput sequencing; Ig variable region ge

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Heuristic-based tabu search algorithm for folding two-dimensional AB off-lattice model proteins

Keywords: TS; tabu search; HTS; heuristic-based tabu search; 2D; two-dimensional; nPERMis; new pruned-enriched-Rosenbluth method with importance sampling; ACMC; annealing contour Monte Carlo algorithm; CSA; conformational space annealing; STA; statistical temperatu

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

A small molecule inhibitor of fungal histone acetyltransferase Rtt109

Keywords: H3K56; histone H3 lysine 56; HAT; histone acetyltransferase; HTS; high throughput screen; CoA; coenzyme A; Ac-CoA; acetyl-coenzyme A; DTNB; 5,5′-dithiobis-(2-nitrobenzoic acid); HPLC/MS; high pressure liquid chromatography/mass spectrometry; PBS; phosph

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The development of CNS-active LRRK2 inhibitors using property-directed optimisation

Keywords: PD; Parkinson's disease; LRRK2; leucine-rich repeat kinase 2; DLP1; dynamin-like protein 1; FOXO1; forkhead box transcription factor; 4E-BP; eukaryotic initiation factor 4E (eIF4E)-binding protein; SBDD; structure-based drug design; HTS; high throughput

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Development and characterization of a stable eGFP enterovirus 71 for antiviral screening

Keywords: EV71; enterovirus 71; HTS; high-throughput screen; hpi; hour post-infection; pt; post-transfection; pi; post-infection; eGFP; enhanced green fluorescent protein; GuHCl; guanidine hydrochloride; Enterovirus; Reporter virus; High-throughput assay; Antiviral

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery

Keywords: FXR; farnesoid X receptor; NRs; nuclear receptors; HTS; high-throughput screen; LBD; ligand-binding domain; TR-FRET; time resolved fluorescence resonance energy transfer;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Novel inhibitors of bacterial virulence: Development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression

Keywords: GAS; Group A Streptococcus (Streptococcus pyogenes); SK; streptokinase; MRSA; methicillin-resistant Staphylococcus aureus; VRE; vancomycin-resistant Enterococcus; HTS; high-throughput screening; SAR; Structure-activity relationship; MLM; mouse liver mic

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase

Keywords: BLM; Bloom helicase; SAR; structure activity relationship; HTS; high throughput screen; ADME; absorption, distribution, metabolism and excretion; MLM; mouse liver microsomes; NADPH; nicotinamide adenine dinucleotide phosphate; PBS; phosphate buffered sali

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2013 سفارش ترجمه

A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells

Keywords: ALS; amyotrophic lateral sclerosis; iPSC; induced pluripotent stem cells; TDP-43; TARDBP, TAR DNA binding protein; SOD1; superoxide dismutase 1; FTLD; fronto-temporal lobar degeneration; iPSC-MN; induced pluripotent stem cell-derived motor neurons; iPSC-C

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2013 سفارش ترجمه

Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors

Keywords: BSA; bovine serum albumin; DMSO; dimethyl sulfoxide; HIV; human immunodeficiency virus; HTS; high-throughput screening; IN; integrase; INBIs; IN binding inhibitors; INSTIs; integrase strand transfer inhibitors; LTR; long terminal repeat; PBS; phosphate bu

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2013 سفارش ترجمه

Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists

Keywords: EP1 receptor antagonist; Pyrazole; Thiazole; Overactive bladder; HTS

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

HTS planar gradiometer consisting of SQUID with multi-turn input coil and large pickup coil made of GdBCO coated conductor

Keywords: SQUID; HTS; Gradiometer; Balance; Baseline; Coated conductor

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Prospects of High Temperature Superconductors for fusion magnets and power applications

Keywords: High Temperature Superconductor; HTS; High current cable; Fusion; Magnet

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Screening-based discovery of the first novel ATP competitive inhibitors of the Staphylococcus aureus essential enzyme UMP kinase

Keywords: UMP kinase; PyrH; HTS; Antibacterial targets; Inhibitor; Screening;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Complex study of transport AC loss in various 2G HTS racetrack coils

Keywords: AC losses; HTS; Substrate;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

New high throughput screening method for drug release measurements

Keywords: HTS; Release profile; Controlled drug delivery

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

High-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity

Keywords: HTS; FRET; Deubiquitinase assay; AMSH

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Fully filamentized HTS coated conductor via striation and selective electroplating

Keywords: Ac losses; Filamentary; Thin film; HTS; Coated conductor; Critical current

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Cytotoxicity of commercial nano-TiO2 to Escherichia coli assessed by high-throughput screening: Effects of environmental factors

Keywords: Nano-TiO2; Cytotoxicity; HTS; Bacteria; Illumination wavelength; SRFA

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Identification of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one derivatives as inhibitors of the phosphatase SerB653 in Porphyromonas gingivalis, implicated in periodontitis

Keywords: IC50; half-maximal inhibitory concentration; MIC; minimum inhibitory concentration; IL-8; interleukin-8; PMSF; phenylmethylsulfonyl fluoride; DMSO; dimethyl sulfoxide; MAPK; mitogen-activated protein kinase; Periodontitis; Gram-negative anaerobe; Haloacid

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor

Keywords: GPCRs; HTS; APJ; Apelin; Cardiovascular disease; Antagonists; SAR;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Design research on the conductor of 10 kA class HTS DC power cable

Keywords: 10 kA; HTS; DC; Power cable

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

A novel high-throughput cellular screening assay for the discovery of HIV-1 integrase inhibitors

Keywords: HIV; Integrase; Inhibitors; Screening; HTS;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Fast mouse PK (Fast PK): A rapid screening method to increase pharmacokinetic throughput in pre-clinical drug discovery

Keywords: PK; pharmacokinetics; PD; pharmacodynamics; PO; per oral; IV; intravenous; HTS; high throughput screening; DMPK; drug metabolism and pharmacokinetics; AUC; area under the curve; HPMC; hydroxypropylmethyl cellulose; CMC; carboxymethyl cellulose; Pharmacoki

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling

Keywords: Smo; smoothened; Hh; hedgehog; Ptc; patched; Shh; sonic hedgehog; β arr2; β-arrestin2; β arr2-GFP; β-arrestin2-green fluorescent protein chimera; Gli; glioma-associated oncogene; GPCR; G-protein-coupled receptor; V2R; vasopressin2 receptor; HTS; high-

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Lymphopenia induced by a novel selective S1P1 antagonist structurally unrelated to S1P

Keywords: S1P; sphingosine 1-phosphate; S1P1; type 1 sphingosine 1-phosphate receptor; CHS; contact hypersensitivity response; HEK293; human embryonic kidney cell line; CHO-K1; Chinese hamster ovary cell line; HTS; high-throughput screening; GTP; guanosine-5′-tri

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Quantitative microtiter fibronectin fibrillogenesis assay: use in high throughput screening for identification of inhibitor compounds

Keywords: Fibronectin; Fibrillogenesis; Extracellular matrix; HTS; Kinase inhibitors; Piperlongumine; Cantharidin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

BioProfile-Extract knowledge from corporate databases to assess cross-reactivities of compounds

Keywords: HTS; high throughput screening; BI; Boehringer Ingelheim; POC; percent of control; DB; database; DR; dose response; Data mining; Cross reactivities; Frequent Hitter; BioProfile;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

BACE1 in Alzheimer's disease

Keywords: Aβ; β-amyloid; ACDL; acid-cluster dileucine motif; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease domain protein; AICD; amyloid precursor protein intracellular domain; APLP; amyloid precursor-like protein; ApoE; apolipoprotein E; APP;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Automated neurosphere sorting and plating by the COPAS large particle sorter is a suitable method for high-throughput 3D in vitro applications

Keywords: DNT; developmental neurotoxicity; NPC; neural progenitor cell; COPAS; complex object parametric analyzer and sorter; HTS; high throughput screening; ROS; reactive oxygen species; DCF; dichlorofluorescin; PDL; poly-d-lysin; AU; arbitrary units; TOF; time o

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Fluorescence properties of the anti-tumour alkaloid luotonin A and new synthetic analogues: pH modulation as an approach to their fluorimetric quantitation in biological samples

Keywords: CE; Capillary electrophoresis; ESPT; Excited state proton transfer reactions; HPLC; High performance liquid chromatography; HTS; High throughput screening; LOD; Limit of detection; LOQ; Limit of quantitation; NMR; Nuclear magnetic resonance; QY; Quantum y

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Lack of a Functional VHL Gene Product Sensitizes Renal Cell Carcinoma Cells to the Apoptotic Effects of the Protein Synthesis Inhibitor Verrucarin A

Keywords: cFLIP; cellular-FLICE inhibitory protein; CHX; cycloheximide; CCRCC; clear cell renal cell carcinoma; HTS; high-throughput screen; pVHL; VHL gene protein product; SG; stress granule; VA; verrucarin A or muconomycin A; VHL; von Hippel-Lindau; VHL-/-; VHL-d

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Hydroxyethyl disulfide as an efficient metabolic assay for cell viability in vitro

Keywords: G6PD; glucose-6-phosphate dehydrogenase; HEDS; hydroxyethyldisulfide; OPPC; oxidative pentose phosphate cycle; ME; mercaptoethanol; DTNB; dithiobisnitrobenzoicacid; HTS; high throughput screening; Glutathione; Glucose metabolism; Cytotoxicity; Cell prolif

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Ras inhibition via direct Ras binding-is there a path forward?

Keywords: ATP; adenosine triphosphate; FTase; farnesyltransferase; FTmap; fourier transform correlation mapping; GAP; GTPase activating protein; GDP; guanosine diphosphate; GEF; guanine-nucleotide exchange factor; GST; glutathione s-transferase; GTP; guanosine trip

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

High-throughput screening for genes that prevent excess DNA replication in human cells and for molecules that inhibit them

Keywords: HTS; high throughput screening; EDR; excess DNA replication; FACS; fluorescence activated cell sorting; siRNA; small interfering RNA; RNAi; RNA interference; OTEs; off-target effects; High throughput screening; DNA re-replication; Endoreduplication; Endoc

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action

Keywords: GPCR; CB2 agonists; HTS; SAR; Inflammatory pain models;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2012 سفارش ترجمه

Characterization of tyrosine kinase and screening enzyme inhibitor by capillary electrophoresis with laser-induced fluoresce detector

Keywords: HTS; high throughput screening; CE; capillary electrophoresis; TK; tyrosine kinase; ATP; adenosine triphosphate; ELISA; enzyme-linked immunosorbent assay; LIF; laser-induced fluorescence; MOPS; 3-(N-morpholino)-propanesulfonic acid; ADP; adenosine diphosp

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Development of a microplate fluorescence assay for kynurenine aminotransferase

Keywords: Fluorescence; Kynurenine aminotransferase; HTS; Enzymatic assay; Inhibitors

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Development of a high-throughput human rhinovirus infectivity cell-based assay for identifying antiviral compounds

Keywords: Human rhinovirus; HRV serotypes; High-throughput screen; HTS; HeLa OHIO; Cytopathic effect; CellTiter-Glo; Antiviral agents;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Monitoring of particle growth at a low concentration of a poorly water soluble drug using the NanoSight LM20

Keywords: HTS; Solubility; Nanoparticle growth; NTA; DLS; Tolnaftate;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Using cheminformatics to find simulants for chemical warfare agents

Keywords: Chemical warfare agents; Molecular descriptors; Simulants; Similarity search; Tanimoto coefficient; Euclidean distance; BCUT; Burden Chemical Abstracts Service and the University of Texas; CAS; Chemical Abstracts Service; CWAs; Chemical warfare agents; ED

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Natural products and the search for novel vaccine adjuvants

Keywords: NPs; natural products; MDP; muramyl dipeptide; PGN; peptidoglycan; NOD1; nucleotide-binding oligomerization domain 1; CLRs; C-type lectin receptors; NLRs; nucleotide oligomerization domain-like receptors; RLRs; RIF-I-(retinoic acid-inducible gene 1)-like

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibitors of SARS-CoV entry – Identification using an internally-controlled dual envelope pseudovirion assay

Keywords: Inhibitors of SARS-CoV entry; Antiviral; HTS; High-throughput screening; Dual envelope pseudovirion assay; Pseudovirus

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

The Romanian speech synthesis (RSS) corpus: Building a high quality HMM-based speech synthesis system using a high sampling rate

Keywords: Speech synthesis; HTS; Romanian; HMMs; Sampling frequency; Auditory scale

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors

Keywords: RNA-dependent RNA polymerase; RdRP; Inhibitor; Poliovirus; HTS; RNA

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Crack–inclusion problem for a long rectangular slab of superconductor under an electromagnetic force

Keywords: HTS; Crack–inclusion; Finite element analysis; Stress intensity factor; Magnetic field; Electromagnetic force

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

A miniaturized HTS microwave receiver front-end subsystem for radar and communication applications

Keywords: HTS; Filter; Cryocooler; Subsystem

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه