Synthesis of 6″-triazole-substituted α-GalCer analogues as potent iNKT cell stimulating ligands
Keywords: α-GalCer; CD1d; iNKT cell; Triazole; IL-2; Click chemistry
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Dissecting the effects of endogenous brain IL-2 and normal versus autoreactive T lymphocytes on microglial responsiveness and T cell trafficking in response to axonal injury
Keywords: IL-2; Knockout; Neuroimmunology; Congenic mice; Immune reconstitution; T cells; Microglia; Motoneuron; Nerve injury; Autoimmunity; Brain
Antitumor activity and immunomodulatory effects of the intraperitoneal administration of Kanglaite in vivo in Lewis lung carcinoma
Keywords: Kanglaite; Coix seed; Lewis lung carcinoma; Immunomodulatory; NF-kappaB; IL-2;
Effects of in vivo injection of anti-chicken CD25 monoclonal antibody on regulatory T cell depletion and CD4+CD25− T cell properties in chickens
Keywords: Tregs, regulatory T cellsTregs; T cells; IL-2; IFNγ
Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells
Keywords: IL-2; TGF-beta; Rapamycin; Induced regulatory T cell; Controlled release PLGA
GB virus C: the good boy virus?
Keywords: GBV-C; HIV; T cell; activation; IL-2
The role of cytokines in the establishment, persistence and eradication of the HIV reservoir
Keywords: HIV; Viral reservoirs; Cytokines; Memory CD4+ T cells; HAART; IL-7; IL-2
Magnesium-deficiency does not alter calcineurin inhibitors activity in mice
Keywords: CN, calcineurin; CsA, cyclosporin; TAC, tacrolimus; Mg2+, magnesium; MLR, mixed lymphocyte reaction; SC, spleen cellImmunosuppressive drugs; Cyclosporin; Tacrolimus; Hypomagnesemia; Calcineurin activity; IL-2; MLR
Research ArticleNaïve CD8 T cell activation by liver bone marrow-derived cells leads to a “neglected” IL-2low Bimhigh phenotype, poor CTL function and cell death
Keywords: IL-2R; interleukin-2 receptor; bm; bone marrow; IL-2; interleukin-2; KC; Kupffer cells; LSEC; liver sinusoidal endothelial cells; DC; dendritic cells; APC; antigen presenting cells; ICAM-1; intercellular adhesion molecule-1; LN; lymph node; TCR; T cell re
Circadian Aspects of Growth Hormone–Insulin-Like Growth Factor Axis Function in Patients With Lung Cancer
Keywords: Circadian rhythmicity; GH; IGF1; IL-2; Lung cancer; Melatonin
SJSZ glycoprotein (38 kDa) prevents thymus atrophy and enhances expression of IL-2 and IL-12 in diethylnitrosamine-induced hepatocarcinogenesis
Keywords: SJSZ glycoprotein (38 kDa); Thymic atrophy; T-bet/GATA-3; IL-2; IL-12
Pharmaceutical NanotechnologyAggregation behavior and in vitro biocompatibility study of octopus-shaped macromolecules based on tert-butylcalix[4]arenes
Keywords: Calix[4]arenes; PEO; Self-assembled structures; Biocompatibility; Cytotoxicity; Hemolysis; IL-2;
Phytocomponent p-Hydroxycinnamic acid inhibits T-cell activation by modulation of protein kinase C-θ-dependent pathway
Keywords: p-Hydroxycinnamic acid; Immunosuppression; IL-2; Apoptosis; T-cell activation; Protein kinase C-θ
Nitric oxide affects immune cells bioenergetics
Keywords: CsA; cyclosporine A; DMSO; dimethyl sulfoxide; DO; dissolved oxygen; GLUT; glucose transporter; IL-2; interleukin-2; iNOS; inducible nitric oxide synthase; MPTP; mitochondrial permeability transition pore; NO; nitric oxide; NSAID; non-steroidal anti-infla
Immune responses elicited by a fourth dose of the HPV-16/18 AS04-adjuvanted vaccine in previously vaccinated adult women
Keywords: AE; adverse event; ATP; according-to-protocol; CD40L; CD40 ligand; CI; confidence interval; CMI; cell-mediated immune; CVS; cervico-vaginal secretion; DNA; deoxyribonucleic acid; ELISA; enzyme-linked immunosorbent assay; Gmean; geometric mean; GMT; geomet
B cell increases and ex vivo IL-2 production as secondary endpoints for the detection of sensitizers in non-radioisotopic local lymph node assay using flow cytometry
Keywords: LLNA; local lymph node assay; tLLNA; traditional local lymph node assay; BrdU; 5-bromo-2â²-deoxyuridine; FCM; flow cytometry; Non-radioisotopic local lymph node assay; 5-Bromo-2â²-deoxyuridine; Flow cytometry; B cell; Cytokine; IL-2;
Polymyxin B increases the depletion of T regulatory cell induced by purinergic agonist
Keywords: PMB; polymyxin B; Treg; regulatory T cells; IL-2; interleukin 2; CD25; interleukin 2 receptor α chain; BBG; brilliant blue G; oATP; oxidized ATP; PPADS; pyridoxal-phosphate-6-azophenyl-2â²,4â²-disulfonate; NAD; nicotinamide adenine dinucleotide; BzATP;
Safety Science ArticleIdentification of contact and respiratory sensitizers according to IL-4 receptor α expression and IL-2 production
Keywords: Chemical contact and respiratory sensitizers; Flow cytometry; IgE-positive B cells; IL-2; IL-4; IL-4Rα;
Down-regulation of interleukin-2 production by CD4+ T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription
Keywords: NFAT, nuclear factor of activated T cells; PD-1, programmed death-1; PI3K, phosphatidylinositol 3-kinase; PMA, phorbol myristate acetate; SD, standard deviation; TIM-3, T cell immunoglobulin mucin domain containing molecule-3AP-1; CD4+ T cells; IL-2; NFAT
Study of biomaterial-induced macrophage activation, cell-mediated immune response and molecular oxidative damage in patients with dermal bioimplants
Keywords: AOPPs; advanced oxidation protein products; AR; adverse reactions; CAHA; calcium hydroxylapatite; ChT; human chitotriosidase; FACS; fluorescence-activated cell sorting; FLPs; fluorescent peroxidation products; HA; hyaluronic acid; HLA-class II; human leuk
Glycohydrolases β-hexosaminidase and β-galactosidase are associated with lipid microdomains of Jurkat T-lymphocytes
Keywords: Acidic glycohydrolases; Membrane microdomains; T-lymphocytes; ASB-14; amidosulfobetaine-14; Brij 98; polyoxyethylene (20) oleyl ether; CNS; central nervous system; CT-B; cholera toxin B subunit; EEA1; early endosome antigen 1; EZ-link Sulfo-NHS-LC-Biotin;
The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of γδ T lymphocytes in pigs
Keywords: BAL; bronchoalveolar lavage; BM; bone marrow; GF; germ-free; IL-2; interleukin 2; MHC-II; major histocompatibility complex class II; MLN; mesenteric lymph nodes; PBS; phosphate buffered saline; PMA; phorbol-12-myristate-13-acetate; SWC1, SWC7; swine works
Channel catfish leukocyte immune-type receptor mediated inhibition of cellular cytotoxicity is facilitated by SHP-1-dependent and -independent mechanisms
Keywords: IpLITRs; Ictalurus punctatus leukocyte immune-type receptors; SH2; Src homology 2; SHP; Src homology 2 domain-containing cytoplasmic phosphatase; Csk; C-terminal Src kinase; ITAM; immune receptor tyrosine-based activation motif; SFK; Src-family protein ty
Intravitreous interleukin-2 treatment and inflammation modulates glial cells activation and uncrossed retinotectal development
Keywords: IL-2; critical period; development; superior colliculus; plasticity; glial cellsDAPI, 4′,6-diamidino-2-phenylindole; GFAP, glial fibrillary acidic protein; HRP, horseradish peroxidase; IL-2, interleukin-2; LTD, long-term depression; LTP, long-term potenti
On the pulmonary toxicity of oxygen. 4. The thyroid arena
Keywords: Pulmonary oxygen toxicity; Thyroid factors in lung disease; Effect of birth on thyroid size; Respiratory distress syndrome; Hyaline membrane disease; Animal models for human disease; Starvation metabolism; Defined subset of premature newborns; IL-2; hCG
The transferrin receptor and the targeted delivery of therapeutic agents against cancer
Keywords: AD; adamantane; ADEPT; antibody-directed enzyme prodrug therapy; ADR; doxorubicin/adriamycin; Av; avidin; AVET; adenovirus-enhanced transferrinfection; ART; artemisinin; BAP; biotin-adaptor peptide; BBB; blood-brain barrier; BFU-E; blast forming unit-er
A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells
Keywords: Centella asiatica; Apiaceae; Ursane-type triterpene glycoside; Asiaticoside G; IL-2; Anti-inflammatory; Nitric oxide; Tumor necrosis factor-α
Loss of CNS IL-2 gene expression modifies brain T lymphocyte trafficking: Response of normal versus autoreactive Treg-deficient T cells
Keywords: IL-2; Neuroimmunology; Congenic mice; Gene deletion; T cells; Autoimmunity; Brain
Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling
Keywords: CD25; Curcumin; Foxp3; IκB; IL-2; JAK-STAT pathway; T-lymphocyte;
Inonotus obliquus extracts suppress antigen-specific IgE production through the modulation of Th1/Th2 cytokines in ovalbumin-sensitized mice
Keywords: OVA; ovalbumin; ConA; concanavalin A; LPS; lipopolysaccharide; IL-4; interleukin-4; IFN-γ; interferon-γ; IL-2; interleukin-2; NO; nitric oxide; TNF-α; tumor necrosis factor-α; IO; Inonotus obliquus; Ig; immunoglobulin; IOE; Inonotus obliquus hot water
JunB and c-Rel cooperatively enhance Foxp3 expression during induced regulatory T cell differentiation
Keywords: Treg, regulatory T cells; TCR, T cell receptor; TGF-β, transforming growth factor; IL-2, interleukin-2; ChIP, chromatin immunoprecipitationFoxp3; Transcription; TCR; TGF-β; IL-2; Epigenetics; JunB; c-Rel
The analgesic and anti-rheumatic effects of Thladiantha dubia fruit crude polysaccharide fraction in mice and rats
Keywords: TF-P; Thladiantha dubia fruit crude polysaccharide fraction; RA; rheumatoid arthritis; SOD; superoxide dismutase; MDA; malondialdehyde; NO; nitric oxide; CFA; complete Freund's adjuvant; IL-2; interleukin-2; TNF-α; tumor necrosis factor-α; NSAID; non-st
IL-2: A two-faced master regulator of autoimmunity
Keywords: IL-2; Regulatory T-cells; Th cytokines; Trafficking; Inflammation; Autoimmunity; Scurfy
Human activated CD4+ T lymphocytes increase IL-2 expression by downregulating microRNA-181c
Keywords: miRNA; microRNA; mAb; monoclonal Ab; 3â² UTR; 3â² untranslational region; N.C.; negative-control scrambled miRNA; mRNA; messenger RNA; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-dimethyltetrazolium bromide; ELISA; enzyme-linked immunosorbent assay; miRNA; mi
Targeted immunotherapy for acute myeloid leukemia
Keywords: acute myeloid leukemia; AML; allogeneic; graft versus leukemia; GVL; hematopoietic stem cell transplantation; HSCT; interleukin-2; IL-2; killer immunoglobulin-like receptors; KIR; natural killer; NK; T cell
IL-2 limits IL-12 enhanced lymphocyte proliferation during Leishmania amazonensis infection
Keywords: Leishmania; IL-2; IL-12; Tolerance; T cell
ER stress impairs MHC Class I surface expression and increases susceptibility of thyroid cells to NK-mediated cytotoxicity
Keywords: BiP; binding protein (GRP78); ER; endoplasmic reticulum; ERAD; ER associated degradation; GRP94; glucose regulated protein 94; HFE; hereditary hemochromatosis protein; HLA-I; human leukocyte antigen-I; IFN-γ; interferon-γ; IL-2; interleukin-2; MHC-I; ma
Mechanisms of cytokine secretion: A portfolio of distinct pathways allows flexibility in cytokine activity
Keywords: IL-1β; IL-2; IL-12; IL-15; TNF-α
The interleukin-2 antagonizing antibody MT204 delays allogeneic skin graft rejection in non-human primates and is well tolerated
Keywords: IL-2; Immunotherapy; Monoclonal antibody; Primate; Transplantation
hsBAFF regulates proliferation and response in cultured CD4+ T lymphocytes by upregulation of intracellular free Ca2+ homeostasis
Keywords: Human soluble BAFF; CD4+ T lymphocyte; Calcium ion; IL-2; INF-γ2-APB, 2-aminoethoxydiphenyl borate; BAFF, B cell activating factor belonging to the TNF family; BAPTA/AM, 1,2-bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid acetoxymethyl ester; BLyS, B l
Topical application of porcine placenta extract inhibits the progression of experimental contact hypersensitivity
Keywords: PE; placenta extract; LPS; lipopolysachharide; TNF-α; tumor necrosis factor alpha; IL-1β; interleukin 1 beta; IFN-γ; interferon gamma; IL-4; interleukin 4; IL-6; interleukin 6; IL-2; interleukin 2; IL-17; interleukin 17; CHS; contact hypersensitivity;
Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel
Keywords: IRF-4; interferon regulatory factor-4; IFN; interferon; ISRE; IFN-stimulated response element; TCR; T-cell receptor; PMA; phorbol-12-myristate-13-acetate; I; Ionomycin; TAP; tandem affinity purification; IL-4; interleukin-4; HTLV-1; human adult T-cell leu
Cell activation by CpG ODN leads to improved electrofusion in hybridoma production
Keywords: CpG ODN; CpG oligodeoxynucleotide; PEG; Polyethyleneglycol; HAT; Hypoxanthine; LPS; Lipopolysaccharide; PWM; Pokeweed mitogen; IL-2; Interleukin-2; PBS; Phosphate buffered saline; FBS; Fetal bovine serum; IL-10; Interleukin-10; IL-12; Interleukin-12; GM-C
Enhancing the potency of a whole-cell breast cancer vaccine in mice with an antibody-IL-2 immunocytokine that targets exposed phosphatidylserine
Keywords: IL-2; interleukin 2; IFNγ; interferon gamma; PS; phosphatidylserine; HRP; horseradish peroxidase; i.p.; intraperitoneal(ly); s.c.; subcutaneous(ly); ADCC; antibody dependent cellular cytotoxicity; ROS; reactive oxygen species; Phosphatidylserine; Cancer
The HIV-1 Nef protein has a dual role in T cell receptor signaling in infected CD4+ T lymphocytes
Keywords: HIV-1; Nef; CD4+ T lymphocytes; TCR; T cell activation; NFAT; IL-2
Application of cellular biosensors for analysis of bioactivity associated with airborne particulate matter
Keywords: Fluorescent Cell Chip; Oxibios; Airborne particulate matter; IL-2; IL-4; IFN-γ; IL-10; NFκB
Comparison of GD2 binding capture ELISA assays for anti-GD2-antibodies using GD2-coated plates and a GD2-expressing cell-based ELISA
Keywords: ADCC; antibody-dependent cellular cytotoxicity; CbELISA; cell-based ELISA; CDC; complement-dependent cytotoxicity; ch14.18; mouse-human chimera of mAb14.18; DPBS; Dulbecco's phosphate-buffered saline; FACS; fluorescence activated cell sorting; FBS; fetal
Research ReportCyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages
Keywords: CyCAP; cyclophilin C-associated protein; CsA; cyclosporin A; DAPI; 4â²,6â²-diamidine-2-phenylindole dihydrochloride; GFAP; glial fibrillary acidic protein; GFP; green fluorescent protein; IL-2; interleukin 2; IP; Immunoprecipitate; MCA; middle cerebral
Reduced TH1/TH17 CD4 T-cell numbers are associated with impaired purified protein derivative-specific cytokine responses in patients with HIV-1 infection
Keywords: HIV; Mycobacterium tuberculosis; tuberculosis; CD4; TH1/TH17 cells; IFN-γ; IL-2; APC; Allophycocyanin; ART; Antiretroviral therapy; BAL; Bronchoalveolar lavage; CV; Coefficient of variation; ELISPOT; Enzyme-linked immunospot; PE; Phycoerythrin; PerCP; Pe
Bone Marrow Stromal Cell Transplants Prevent Experimental Enterocolitis and Require Host CD11b+ Splenocytes
Keywords: Crohn's Disease; Mesenchymal Stem Cells; Monocyte; Imaging; DC; dendritic cell; IL-2; interleukin-2; MSC; bone marrow stromal cell; TNBS; trinitrobenzosulfonic acid; Tregs; T regulatory cells;