Keywords: diabetes; heart failure; metabolism; obesity; Krüppel-like factors; APOE; apolipoprotein E; ATP; adenosine triphosphate; BAT; brown adipose tissue; BCAA; branched chain amino acid; C/EBP; CCAAT/enhancer-binding protein; CBP; cAMP response element binding
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Keywords: Retinal ganglion cells; Axon regeneration; Cancer genes; PTEN; Visual system repair mechanisms; AAV; Adeno-associated virus; CNS; Central Nervous System; CNTF; ciliary neurotrophic factor; DLK; dual leucine zipper kinase; DRG; dorsal root ganglion; EGFR;
Keywords: 4-HPR; N-(4-hydroxyphenyl)retinamide; 5â²-UTR; 5â²-untranslated region; 9-cis-RA; 9-cis retinoic acid; 9cUAB30; (2E,4E,6Z,8E)-8-(3â²,4â²-dihydro-1â²(2'H)-naphthalen-1â²-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid; Acitretin; (2E,4E,6E,8E)-9-(4-met
Keywords: AP-1; activator protein 1; BMDAC; bone marrow-derived angiogenic cells; Egr; early growth response transcription factor; HIF; hypoxia-inducible factor; HOX; homeobox; IL-1; interleukin 1; iNOS; inducible nitric oxide synthase; KLF; Kruppel-like factor; MI
Keywords: cDC; conventional dendritic cells; CDP; common dendritic cell precursors; cMoP; common monocyte progenitor; CMP; common myeloid precursors; CNS; central nervous system; DC; dendritic cells; GMP; granulocyte-macrophage precursors; HSC; hematopoietic stem c
Keywords: TERT; telomerase reverse transcriptase; RNP; ribonucleoprotein; TR; telomerase RNA; CSCs; cancer stem cells; TEN; telomerase essential N-terminal; TRB; TERT RNA-binding; RT; reverse transcriptase; CTE; C-terminal extension; DAT; dissociates activities of
Keywords: AP-1; activator protein-1; BLNK; B cell linker protein; BTK; Bruton's tyrosine kinase; CCT; choline cytidylyltransferase; CDP-choline; cytidine diphosphocholine; CEPT1; choline/ethanolamine phosphotransferase 1; Cer; ceramide; CK; choline kinase; CPT1; ch
The MEK5/ERK5 mitogen-activated protein kinase cascade is an effector pathway of bone-sustaining bisphosphonates that regulates osteogenic differentiation and mineralization
Keywords: ANOVA; analysis of variance; ANT; adenine-nucleotide-translocase; ALPL; alkaline phosphatase; Apppl; ATP analogue triphosphoric acid-1-adenosine-5â²yl ester 3-(3-methylbut-3-enyl) ester; BP; bisphosphonate; EC; endothelial cell; eNOS; endothelial nitric
Krüppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity
Keywords: Kruppel-like factor; KLF; KLF15; Transcription; Circadian; Nitrogen; Branched chain amino acid; Bcaa; Gluconeogenesis; Heart failure; Metabolism; Skeletal muscle; Cardiac muscle; Liver; Arrhythmia; Fasting;
Cholangiocytes: Cell transplantation
Keywords: ALDH; Aldehydedehydrogenase; CD; Cluster differentiation; EGF; Epidermal growth factor; EpCAM; Epithelial cell adhesion molecule; ECM; Extracellular matrix; FGF; Fibroblast growth factor; GMP; Good manufacturing practice; G-CSF; Granulocyte colony-stimula
Genetic variants in the promoter region of the KLF3 gene associated with fat deposition in Qinchuan cattle
Keywords: KLF; Krüppel-like factors; MAS; molecular marker-assisted selection; SNPs; single nucleotide polymorphisms; IFC; intramuscular fat content; BT; backfat thickness; C/EBPα; CCAAT/enhancer-binding protein alpha; qPCR; quantitative real-time PCR; RT; revers
Role of Kruppel homolog 1 (Kr-h1) in methyl farnesoate-mediated vitellogenesis in the swimming crab Portunus trituberculatus
Keywords: Kr-h1; Kruppel homolog 1; KLF; Kruppel-like factor; JH; juvenile hormone; MF; methyl farnesoate; RACE; rapid amplification of cDNA ends; Met; Methoprene-tolerant; SRC; steroid receptor coactivator; bHLH-PAS; basic helix-loop-helix Per/Arnt/Sim; JHRE;
KLF15 promotes transcription of KLF3 gene in bovine adipocytes
Keywords: KLF; Krüppel-like factors; EMSA; Electrophoretic mobility shift; ChIP; Chromatin immunoprecipitation; IMF; Intramuscular fat content; PPARγ; Peroxisome proliferator-activated receptor; GLUT4; glucose transport protein; EAMC; Committee of Experimental An
Regulatory crosstalk between KLF5, miR-29a and Fbw7/CDC4 cooperatively promotes atherosclerotic development
Keywords: Fbw7/CDC4; F-box and WD40 repeat domain-containing 7; HASMC; Human aortic smooth muscle cells; CAD; Coronary artery disease; KLF; Krüppel-like factor; CBP; CREB-binding protein; miR; microRNA; oxLDL; Oxidized low-density lipoprotein; qRT-PCR; Quantitativ
Bioinformatics analysis of non-synonymous variants in the KLF genes related to cardiac diseases
Keywords: KLF; Kruppel-like Factors; ZF; zinc-finger; HCM; hypertrophic cardiomyopathy; Nkx2; NK2 Homeobox; Nkx2.5; NK2 Homeobox 5; TBX5; T-box transcription factor 5; Sp1; transcription factor Sp1; CtBP; Carboxy-terminal binding protein; Sin3A; SIN3 transcription
EMT: Mechanisms and therapeutic implications
Keywords: AJ; adherens junction; aPKC; atypical protein kinase; BM; basement membrane; βHLH; Beta helix-loop-helix; CSC; cancer stem cells; ECM; extracellular matrix; EMT; epithelial mesenchymal transition; FOX; Forkhead box; GAP; GTPase-activating proteins; GDI;
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
Keywords: Vascular smooth muscle; Vasoproliferative disease; Vascular smooth muscle cell; Phenotype switching; Signalling pathways; AJ; adherens junction; ApoE; apolipoprotein E; BMP; bone morphogenetic protein; CAD; coronary artery diseases; CADASIL; cerebral auto
Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice
Keywords: Gene Regulation; Oncogene; Pancreas; Signal Transduction; ADM; acinar-to-ductal metaplasia; CCND1; cyclin D1; ChIP; chromatin immunoprecipitation; DMSO; dimethyl sulfoxide; IF; immunofluorescence; IHC; immunohistochemical; KLF; Krüppel-like factor; KRAS;
Adipocytes spectrum - From homeostasia to obesity and its associated pathology
Keywords: Acrp30 (AdipoQ); adiponectin gene; AdipoR; adiponectin receptor; AGE; angiotensinogen; ALP; alkaline phosphatase; Ang II; angiotensin II; Angptl2; angiopoietin-like protein-2; Aqp7; aquaporin-7; aP2; adipocyte-specific fatty acid binding protein 2 gene; A
β2-glycoprotein I and its antibodies involve in the pathogenesis of the antiphospholipid syndrome
Keywords: ADP; adenosine diphosphate; APS; antiphospholipid syndrome; ICAM; intercellular adhesion molecule; IL; interleukin; IRAK; IL-1 receptor-activated kinase; KLF; Krüppel-like factors; LPS; lipopolysaccharide; MAPK; MAP kinases; MD; myeloid differentiation f
Minimal essential region for krüppel-like factor 5 expression and the regulation by specificity protein 3-GC box binding
Keywords: KLF; Krüppel-like factor; Sp; specificity proteins; MER; minimal essential region; PCR; polymerase chain reaction; Luc; luciferase; siRNA; short interfering RNA; RLA; relative Luc activity; ChIP; chromatin immunoprecipitation; Cancer; Gene transcription;
MicroRNA-145 protects follicular granulosa cells against oxidative stress-induced apoptosis by targeting Krüppel-like factor 4
Keywords: miR-145; Granulosa cell; Oxidative stress; Apoptosis; KLF4; GCs; granulosa cells; ROS; reactive oxygen species; SOD1; superoxide dismutase 1; H2O2; hydrogen peroxide; KLF; Krüppel-like factor; LH; luteinizing hormone; IGF1; insulin-like growth factor 1;
Leflunomide prevents ROS-induced systemic fibrosis in mice
Keywords: Ab; Antibody; AOPP; Advanced oxidation protein products; AU; Arbitrary Unit; mAb; monoclonal Antibody; DHODH; dihydro-orotate dehydrogenase; ECM; Extracellular matrix; FCS; Fetal calf serum; HOCl; Hypochlorous acid; KLF; Krüppfel-like Factor; PBS; Phosph
SP and KLF Transcription Factors in Digestive Physiology and Diseases
Keywords: Specificity Protein; Krüppel-Like Factor; Digestive System; Cancer; Stem Cells; Proliferation; Differentiation; Development; Apoptosis; Cell Cycle; APC; adenomatous polyposis coli; BAX; B-cell lymphoma 2-like protein 4; BCL2; B-cell lymphoma 2; COX2; c
Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis
Keywords: ACACB; acetyl-CoA carboxylase beta acetyl-CoA carboxylase beta; ACAT1; acetyl-CoA acetyltransferase 1; ACLY; ATP citrate lyase; AMPK; 5â²AMP-activated protein kinase; ASCL1; acyl-CoA synthetase long-chain family member 1; ACSL4; acyl CoA synthetases long
Immunohistochemical study of Krüppel-like factor 4 in the spinal cords of rats with experimental autoimmune encephalomyelitis
Keywords: ABC; avidin-biotin-peroxidase-complex; CFA; complete Fruend's adjuvant; CNS; central nervous system; EAE; Experimental autoimmune encephalomyelitis; FITC; fluorescein isothiocyanate; GFAP; glial fibrillary acidic protein; iNOS; inducible nitric oxide
KLF10 affects pancreatic function via the SEI-1/p21Cip1 pathway
Keywords: CDK; cyclin dependent kinase; ChIP; chromatin immunoprecipitation; EMSA; electophoretic mobility shift assay; HOMA; homeostasis model assessments; KLF; Krüppel-like factor; OGTT; oral glucose tolerance tests; SEI-1; selected with Ink4a-1 as bait; SERTAD1
Krüppel-like transcription factor 8 (Klf8) is expressed and active in the neurons of the mouse brain
Keywords: FAK; Focal Adhesion Kinase; KLF; Krüppel-like factor; NLS; nuclear localization signal; ZF; zinc finger; Krüppel-like factor 8; Transcription factor; Mouse brain; Neurons;
Novel zinc finger transcription factor ZFP580 promotes differentiation of bone marrow-derived endothelial progenitor cells into endothelial cells via eNOS/NO pathway
Keywords: bFGF; recombinant rat basic fibroblast growth factor; C2H2; Cys2-His2; DiL-ac-LDL; Dil-conjugated acetylated low-density lipoprotein; ECs; endothelial cells; eNOS; endothelial nitric oxide synthase; EPCs; endothelial progenitor cells; FACS; fluorescence
miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSMC proliferation
Keywords: ATRA; all-trans retinoic acid; cdk2; cyclin-dependent kinase 2; HASMC; human aortic smooth muscle cell; HDAC2; histone deacetylase 2; KLF; Krüppel-like factor; LSD1; lysine-specific demethylase 1; miR; microRNA; NCoR; nuclear receptor corepressor; p21; p
Activation of early phase of adipogenesis through Krüppel-like factor KLF9-mediated, enhanced expression of CCAAT/enhancer-binding protein β in 3T3-L1 cells
Keywords: KLF; Krüppel-like factor; C/EBP; CCAAT/enhancer-binding protein; PPAR; peroxisome proliferator-activated receptor; N.C.; negative control; aP2; fatty acid binding protein 4; LPL; lipoprotein lipase; FAS; fatty acid synthase; SREBP; sterol regulatory elem
Transcription factor KLF9 suppresses the growth of hepatocellular carcinoma cells in vivo and positively regulates p53 expression
Keywords: KLF; Krüppel-like factor; ZNF; Zinc finger domain; SID; Sin3A interaction domain; DOX; Doxycycline; CHX; Cycloheximide; Hepatocellular carcinoma; KLF9; Apoptosis; p53 protein; Transcriptional regulation;
Krüppel-like factors are effectors of nuclear receptor signaling
Keywords: KLF; Krüppel-like factor; NR; nuclear receptor; TF; transcription factor; T3; thyroid hormone; TR; thyroid hormone receptor; CORT; corticosterone; GR; glucocorticoid receptor; PR; progesterone receptor; P4; progesterone; ER; estrogen receptor; E2; estrad
A functional interplay between ZNF217 and Estrogen Receptor alpha exists in luminal breast cancers
Keywords: ZNF217; Estrogen Receptor-α; Breast cancer; Estrogen signalling; Biomarker; Endocrine therapy resistance; KLF; Krüppel-like factor; ERα; estrogen receptor alpha; ER+; ERα-positive; E2; 17β-estradiol; IP; immunoprecipitation; PLA; proximity ligation a
IL-17 inhibits adipogenesis in part via C/EBPα, PPARγ and Krüppel-like factors
Keywords: KLF; Krüppel like factor; IL-; interleukin; GR; glucocorticoid receptor; Egr-2; early growth response gene2 (KROX 20); Srebp1c; sterol regulatory element binding protein 1c; PPARγ; peroxisome proliferator-activated receptor; GRE; glucocorticoid response
Characterization of the expression profiles of adipogenesis-related factors, ZNF423, KLFs and FGF10, during preadipocyte differentiation and abdominal adipose tissue development in chickens
Keywords: PPARγ; ZNF432; KLF; FGF10; Adipogenesis
Retinoid metabolism and its effects on the vasculature
Keywords: ADH; alcohol dehydrogenase; ADMA; asymmetric dimethylarginine; AP-1; activated protein-1; apo14; β-apo-14â²-carotenal; ARVM; adult rat ventricular myocytes; ATBC; Alpha-tocopherol Beta-carotene Cancer Prevention Study; atRA; all-trans retinoic acid; BCO
SUMOylation of Blimp-1 promotes its proteasomal degradation
Keywords: Blimp-1; B lymphocyte induced maturation protein-1; KLF; Krueppel-like factor; PC; plasma cells; SENP; SUMO-specific protease; SUMO; small ubiquitin-like modifier; Plasma cell; SENP1; SUMO protease; Proteasome;
Transcriptional factors that promote formation of white adipose tissue
Keywords: Adipocyte; PPAR; C/EBP; STAT5; KLF; SREBP
Involvement of Neptune in induction of the hatching gland and neural crest in the Xenopus embryo
Keywords: Xenopus; Hatching gland; Neural crest; pax3; KLF
Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish
Keywords: Retina; Retinal ganglion cell; Tubulin; KLF; Optic nerve; p27; Promoter
Transcription of the LAT gene is regulated by multiple binding sites for Sp1 and Sp3
Keywords: LAT; linker of activation in T cells; EMSA; electrophoretic mobility shift assay; KLF; Kruppel-like factor; NK; Natural Killer; NE; nuclear extract; comp.; competitor; Gene regulation; Promoter; T cells; Mast cells;
Structure of the human 5-HT7 receptor gene and characterization of its promoter region
Keywords: 5-HT; 5-hydroxytryptamine; CNS; central nervous system; EMSA; Electrophoresis Mobility Shift Assay; GPCR; G-protein-coupled receptor; KLF; Krüppel-like factor; MAZ; Myc-Associated Zinc finger protein; NCBI; National Center for Biotechnology Information;
A functional screen for Krüppel-like factors that regulate the human γ-globin gene through the CACCC promoter element
Keywords: Krüppel-like factors; γ-Globin; CACCC; Transcription factors; KLF; Gene regulation;
Characterization of the human zinc finger protein 267 promoter: Essential role of nuclear factor Y
Keywords: HSCs; hepatic stellate cells; ZNF267; zinc finger protein 267; ECM; extracellular matrix; C/EBP; CCAAT/enhancer-binding protein; NF-Y; nuclear factor Y; KLF; Kruppel-like factor; KRAB; Kruppel associated box; MMP; matrix metalloproteinase; HEK; human embr