دانلود مقالات ISI درباره هدف پستانداران رپامایسین + ترجمه فارسی

Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's lymphoma

Keywords: هدف پستانداران رپامایسین; Q; quercetin; BL; Burkitt's lymphoma; BCR; B cell receptor; GC; Germinal Center; EBV; Epstein-Barr virus; PI3K; phosphatidylinositol-3-kinase; AKT; AKT or protein kinase B; mTOR; mammalian target of rapamycin; BEZ235; NVP-BEZ235; I-c-Myc; c-Myc inhibi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

The roles of extracellular related-kinases 1 and 2 signaling in CNS myelination

Keywords: هدف پستانداران رپامایسین; Erk; Akt; Fyn; BDNF; Oligodendrocyte; Myelin; Erk1/2; extracellular related-kinase 1 and 2; BDNF; brain-derived neurotrophic factor; NGF; nerve growth factor; NT-3; neurotrophin 3; CNS; central nervous system; PNS; peripheral nervous system; p75NTR; p75 n

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Sporadic versus Tuberous Sclerosis Complex-Associated Angiomyolipomas: Predictors for Long-Term Outcomes following Transcatheter Embolization

Keywords: هدف پستانداران رپامایسین; AML; angiomyolipoma; mTOR; mammalian target of rapamycin; PD; progressive disease; RECIST; Response Evaluation Criteria In Solid Tumors; TSC; tuberous sclerosis complex;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Antidepressant drug action - From rapid changes on network function to network rewiring

Keywords: هدف پستانداران رپامایسین; 5-HT; serotonin; AMPA; amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; DBS; deep brain stimulation; ECS; electroconvulsive shock; ECT; electroconvulsive therapy; GABA; gamma-aminobutyric acid; mTOR; mammalian t

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Lkb1 deletion upregulates Pax7 expression through activating Notch signaling pathway in myoblasts

Keywords: هدف پستانداران رپامایسین; AMPK; AMP-activated protein kinase; BAT; brown adipose tissue; DAPT; N-[N-(3,5-difluorophenacetyl-l-alanyl)]-S-phenylglycine t-butyl ester; FBS; fetal bovine serum; H&E; hematoxylin and eosin; Lkb1; Liver kinase B1; mTOR; mammalian target of rapamycin; N1

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing

Keywords: هدف پستانداران رپامایسین; Rottlerin; AMPK; mTOR; 4EBP-1; Autophagy; Protein synthesis; RPMI; Roswell Park Memorial Institute (RPMI); Becl-1; beclin-1; AMPK; AMP-activated protein kinase; ACC; acetyl-CoA carboxylase; mTOR; mammalian target of rapamycin; raptor; regulatory-associate

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

tPA promotes cortical neuron survival via mTOR-dependent mechanisms

Keywords: هدف پستانداران رپامایسین; DIV; days in vitro; JAK; Janus kinase; mTOR; mammalian target of rapamycin; p2; postnatal day 2; PDL; poly-d-lysine; p-S6; phospho-S6; p-STAT3; phosphorylated signal transducer and activator of transcription 3; tPA; tissue plasminogen activator; Tissue pl

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Dual role of LRRC8A-containing transporters on cisplatin resistance in human ovarian cancer cells

Keywords: هدف پستانداران رپامایسین; A2780WT; drug-sensitive human ovarian cancer cells; A2780CisR; cisplatin resistant A2780 cells; ABC; ATP-binding cassette; Ano6; Anoctamin 6; Apaf-1; apoptotic protease activating factor 1; Atox1; Antioxidant 1 copper chaperone; AP; alkaline phosphatase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

The role of epsilon PKC in acute and chronic diseases: Possible pharmacological implications of its modulators

Keywords: هدف پستانداران رپامایسین; PKC; protein kinase C; IPC; ischemic pre conditioning; RACK; receptor for activated C-kinase; DAG; diacylglycerol; beta COP; coatomer subunit beta; CHOK1; chinese hamster ovary K1; CVD; cardiovascular disease; mKATP; ATP-sensitive mitochondrial potassium

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Desmethylanhydroicaritin isolated from Sophora flavescens, shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion

Keywords: هدف پستانداران رپامایسین; MAPK; mitogen activated protein kinase; PI3K; phosphoinositide 3-kinase; MMP; matrix metalloproteinase; WST-1; 2-(4-iodophenyl)-3(40nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium; DAPI; 4,6-diamidino2-phenylindole dihydrochloride hydrate; PBS; phosphat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Pharmacotherapies for Retinal Detachment

Keywords: هدف پستانداران رپامایسین; AIF; apoptosis-inducing factor; Faim2; Fas apoptotic inhibitory molecule 2; FDA; US Food and Drug Administration; MCP-1; monocyte chemoattractant protein-1; mTOR; mammalian target of rapamycin; PDGF; platelet-derived growth factor; PDGFRα; platelet-deri

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Rapamycin Decreases the Osteogenic Response in Aortic Valve Interstitial Cells Through the Stat3 Pathway

Keywords: هدف پستانداران رپامایسین; ALP; alkaline phosphatase; AVICs; aortic valve interstitial cells; BMP-2; bone morphogenetic protein 2; CAVD; calcific aortic valve disease; LPS; lipopolysaccharide; mTOR; mammalian target of rapamycin; RUNX2; runt-related transcription factor 2; Stat3; s

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells

Keywords: هدف پستانداران رپامایسین; MCE; mitotic clonal expansion; C/EBP; CCAAT/enhancer-binding protein; PPARγ; peroxisome proliferator-activated receptor γ; IR; insulin receptor; PI3K; phosphoinositide 3-kinase; PKB; protein kinase B; Topo IIα and β; DNA Topoisomerase IIα and β; mTO

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Cardiac ubiquitin ligases: Their role in cardiac metabolism, autophagy, cardioprotection and therapeutic potential

Keywords: هدف پستانداران رپامایسین; ATG; autophagy-related gene; AMPK; AMP activated protein kinase; BECN1; beclin1; b-TrCP; beta-transducin repeat-containing protein; Cbl; Casitas B-lineage lymphoma; CHIP; Carboxyl terminus of Hsc70 interacting protein; CHMP2B; charged multivesicular body

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Astemizole-Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosis

Keywords: هدف پستانداران رپامایسین; AST; Astemizole; HIS; Histamine; H1R; Histamine H1 receptor; ROS; Reactive oxygen species; ER; Endoplasmic reticulum; PERK; Protein kinase R-like endoplasmic reticulum kinase; IRE1α; Inositol-requiring enzyme 1; ATF; Activating transcription factor; JNK;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Effects of slow-release urea and rumen-protected methionine and histidine on mammalian target of rapamycin (mTOR) signaling and ubiquitin proteasome-related gene expression in skeletal muscle of dairy cows

Keywords: هدف پستانداران رپامایسین; rumen-protected amino acid; mammalian target of rapamycin; ubiquitin-proteasome system; muscle; dairy cow;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer

Keywords: هدف پستانداران رپامایسین; 4E-BP-1; eukaryotic initiation factor 4E binding protein-1; ATF4; activating transcription factor 4; Bcl2; B-cell lymphoma 2; C/EBP; CAAT/enhancer binding protein; cdc-2; cyclin-dependent kinase 1 (cell division cycle protein 2); CHOP; CAAT/enhancer bindi

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17

Keywords: هدف پستانداران رپامایسین; Purinergic receptors; Oligodendrocytes; Remyelination; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATX; autotaxin; CNS; central nervous system; DRG; dorsal root ganglion; EAE; experimental autoimmune encephalomyelitis; GDNF; glial cell de

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

The role of AMPK in cardiomyocyte health and survival

Keywords: هدف پستانداران رپامایسین; ADP; Adenosine diphosphate; AICAR; 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside; AMPK; Adenosine monophosphate-activated protein kinase; CaMKKβ; Calmodulin-dependent protein kinase kinase beta; CPT1; Carnitine palmitoyltransferase 1; eNOS; Endoth

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis

Keywords: هدف پستانداران رپامایسین; Aβ; Amyloid β; AD; Alzheimer's disease; Akt; protein kinase B; AraC; cytosine arabinoside; ATP; adenosine triphosphate; CaM; calmodulin; CaMKIα; Ca2 +/calmodulin-dependent kinase type 1 alpha; CaMKII; Ca2 +/calmodulin-dependent kinase type II; CDK; c

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

ESAT6 inhibits autophagy flux and promotes BCG proliferation through MTOR

Keywords: هدف پستانداران رپامایسین; Autophagy; Early secretory antigenic target 6; Mycobacterium tuberculosis; Lysosome; Mammalian target of rapamycin; Macrophage;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes

Keywords: هدف پستانداران رپامایسین; ATGL; Adipose triglyceride lipase; CHOP; CCAAT-enhancer-binding protein homologous protein; CLEAR; coordinated lysosomal enhancement and regulation; CMA; chaperone mediated autophagy; CQ; chloroquine; eIF2α; eukaryotic translation initiation factor 2α;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation

Keywords: هدف پستانداران رپامایسین; YAP1; Yes; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; eIF4E; eukaryotic translation initiation factor 4E; PI3K; phosphatidylinositide-3-kinase; WNT; Wingless-type mouse mammary tumor virus integration site family m

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2016 سفارش ترجمه

Intrathecal administration of rapamycin inhibits the phosphorylation of DRG Nav1.8 and attenuates STZ-induced painful diabetic neuropathy in rats

Keywords: هدف پستانداران رپامایسین; STZ; streptozotocin; PDN; painful diabetic neuropathy; DRG; dorsal root ganglion; mTOR; mammalian target of rapamycin; S6K; ribosomal protein S6 kinase; 4E-BP; eukaryotic initiation factor 4E (eIF4E) binding protein; IR; insulin receptor; IRS-1; insulin r

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

Uroguanylin modulates (Na+ + K+)ATPase in a proximal tubule cell line: Interactions among the cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways

Keywords: هدف پستانداران رپامایسین; UGN; uroguanylin; PT; proximal tubule; GFR; glomerular flow rate; NHE3; Na+/H+ exchanger isoform 3; PKA; protein kinase A; PKG; protein kinase G; Gi; inhibitory G protein; PKB; protein kinase B; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy

Keywords: هدف پستانداران رپامایسین; Differentiation; Myoblast; Myotube; Collagen peptide; Hydroxyprolyl-glycine; Hypertrophy; DMEM; Dulbecco's modified Eagle's medium; Hyp; hydroxyproline; Hyp-Gly; hydroxyprolyl-glycine; IGF-1; insulin-like growth factor 1; mTOR; mammalian target of rapamyc

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

Performance of a phosphoflow assay to determine phosphorylation of S6 ribosomal protein as a pharmacodynamic read out for mTOR inhibition

Keywords: هدف پستانداران رپامایسین; Akt; protein kinase B; BSA; bovine serum albumin; CRP; C-reactive protein; CsA; cyclosporine A; CV; coefficient of variation; EDTA; ethylenediaminetetraacetic acid; ELISA; enzyme-linked, immunosorbent assay; ERK; extracellular signal-regulated kinase; Evr

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2016 سفارش ترجمه

Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation

Keywords: هدف پستانداران رپامایسین; mTOR; mammalian target of rapamycin; UVB; ultraviolet-B; NMSC; non-melanoma skin cancer; mTORC1; mTOR complex 1; mTOC2; mTOR complex 2; AKT/PKB; protein kinase B; SCC; squamous cell carcinoma; ERK; extracellular-signal-regulated kinases; MEK; mitogen-acti

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

Unravelling exemestane: From biology to clinical prospects

Keywords: هدف پستانداران رپامایسین; AI(s); aromatase inhibitor (s); AKT; protein kinase B; AREG; amphiregulin; BMD; bone mineral density; CYP; cytochrome P450; DHEAS; dehydroepiandrosterone sulfate; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EMA; European Medicine

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-inhibitor REDD1 in a STAT3-dependent manner

Keywords: هدف پستانداران رپامایسین; HIF; Hypoxia-inducible Factor; IL-6; Interleukin 6; IRS1; Insulin Receptor Substrate 1; Jak; Januskinase; mTOR; Mammalian Target of Rapamycin; MEF; Mouse Embryonic Fibroblast; NF-κB; Nuclear Factor kappa B; n.s.; non-significant; MAPK; Mitogen-Activated

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

Keywords: هدف پستانداران رپامایسین; ACAT1; acetoacetyl-CoA thiolase; ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; AMPK; AMP-activated protein kinase; ATAC; Ada-two-A-containing; BET; bromodomains and extra-terminal motif; BMAL1; PAS domain-containing pr

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1

Keywords: هدف پستانداران رپامایسین; Pparγ; peroxisome proliferator activated receptor γ; aP2; adipocyte protein 2; siRNA; small interfering RNA; MSC; mesenchymal stem cells; DMI; Dexamethasone, IBMX, and Insulin; Dnajb1; DnaJ (Hsp40) Homolog, Subfamily B, Member 1; LCA; licochalcone A; TN

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2016 سفارش ترجمه

Nucleoprotein supplementation enhances the recovery of rat soleus mass with reloading after hindlimb unloading-induced atrophy via myonuclei accretion and increased protein synthesis

Keywords: هدف پستانداران رپامایسین; Nucleoproteins; rpS6; Cell differentiation; Hindlimb suspension; Rat; Akt; protein kinase B; CSAs; cross-sectional areas; mTOR; mammalian target of rapamycin; MyoD; myoblast determination protein; Pax7; transcription factors paired-box 7; PBS; phosphate-b

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2016 سفارش ترجمه

Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model

Keywords: هدف پستانداران رپامایسین; NIK; nuclear factor kappa B-inducing kinase; NF-κB; nuclear factor kappa B; IκB; inhibitor of kappa B; IKK; inhibitor of kappa B kinase; ERK1/2; extracellular signal-regulated kinase 1/2; mTOR; mammalian target of rapamycin; MMP; matrix metalloproteinas

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2016 سفارش ترجمه

ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca2 + signaling

Keywords: هدف پستانداران رپامایسین; a.a.; amino acid; ATP; adenosine triphosphate; BH domain; Bcl-2-homology domain; BI-1; Bax inhibitor-1; BIRD-2; Bcl-2/IP3R disruptor-2; BRCA1; breast and ovarian cancer susceptibility gene 1; [Ca2 +]cyt; cytosolic Ca2 + concentration; CLL; chronic lymph

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2016 سفارش ترجمه

Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1α

Keywords: هدف پستانداران رپامایسین; Akt; protein kinase B; AMPK; AMP-activated protein kinase; AVOs; acidic vesicular organelles; BNIP3; BCL2/adenovirus E1B 19 kDa interacting protein 3; BNIP3L; BCL2/adenovirus E1B 19 kDa interacting protein 3-like; CCND1; cyclin D1; CFSE; 5-(6)-carboxyfl

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2016 سفارش ترجمه

Energy restriction impairs dendritic cell development in C57BL/6J mice

Keywords: هدف پستانداران رپامایسین; AL; ad libitum; BrdU; bromodeoxyuridine; cDC; conventional dendritic cell; CDP; common dendritic cell progenitor; DC; dendritic cell; ER; energy restriction; Flt3L; FMS-like tyrosine kinase 3 ligand; GM-CSF; granulocyte-macrophage-colony stimulating facto

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2016 سفارش ترجمه

Targeting the ROS-HIF-1-endothelin axis as a therapeutic approach for the treatment of obstructive sleep apnea-related cardiovascular complications

Keywords: هدف پستانداران رپامایسین; Obstructive sleep apnea; Cardiovascular disease; Intermittent hypoxia; Oxidative stress; Hypoxia inducible factor-1; Endothelin-1; AHI; apnea-hypopnea index; ARBs; angiotensin II receptor blockers; BP; blood pressure; CAD; coronary artery disease; CamK;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2016 سفارش ترجمه

T-cadherin promotes vascular smooth muscle cell dedifferentiation via a GSK3β-inactivation dependent mechanism

Keywords: هدف پستانداران رپامایسین; BSA; Bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; E; Empty vector; FCS; Foetal calf serum; GSK3β; Glycogen synthase kinase 3β; HRP; Horseradish peroxidase; H-SMC; Human aortic smooth muscle cells; IRS; Insulin receptor substrate; MMP;

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2016 سفارش ترجمه

Nutrient restriction of glucose or serum results in similar proteomic expression changes in 3D colon cancer cell cultures

Keywords: هدف پستانداران رپامایسین; Nutrient restriction; Three dimensional cell culture; Autophagy; Apoptosis; Quantitative proteomics; Colorectal cancer; NR; nutrient restriction; FBS; fetal bovine serum; iTRAQ; isobaric tags for relative and absolute quantification; SIRT1; sirtuin 1; PIA

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2016 سفارش ترجمه

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

Keywords: هدف پستانداران رپامایسین; NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH associated protein 1; TUNEL; terminal deoxynucleotidyl transferase dUTP nick end labeling; MTT; 3-(4,5-di

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2016 سفارش ترجمه

An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy

Keywords: هدف پستانداران رپامایسین; AA; Ascorbic acid; AEM1; ARE expression modulator 1; AEG1; Astrocyte elevated gene-1; Akt; Protein kinase B; AMPK; AMP-activated protein kinase; APL; Acute promyelocytic leukemia; ARE; Antioxidant response element; ATO; Arsenic trioxide; Bach; BTB and CNC

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2016 سفارش ترجمه

Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism

Keywords: هدف پستانداران رپامایسین; ARE; antioxidant response element; ATP; adenosine triphosphate; 5-hmC; hydroxymethylcytosine; ATG; AuTophaGy related; BNIP; Bcl-2/adenovirus E18 19-kDa-interacting protein; Drp1; dynamin related protein 1; EpRE; electrophile response element; eNOS; endoth

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2016 سفارش ترجمه

Cancer TARGETases: DSB repair as a pharmacological target

Keywords: هدف پستانداران رپامایسین; DSB repair; Genome instability; Cancer; Kinases; Helicases; Nucleases; ALT; alternative telomere lengthening; AML; acute myeloid leukemia; A-T; ataxia-telangiectasia; ATM; ataxia-telangiectasia mutated; ATP; adenosine triphosphate; ATR; ataxia-tel

دانلود رایگان متن کامل مقاله ISI 110 صفحه سال انتشار : 2016 سفارش ترجمه

Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation

Keywords: هدف پستانداران رپامایسین; Mammalian target of rapamycin; Hippocampus; Kaplan-Meier; Forebrain-specific Tsc2 Knock-out; mTOR overactivation; mTORC; mechanistic Target of Rapamycin Complex; Rheb; Ras-homolog enriched in brain; S6; ribosomal protein S6; S6K; ribosomal protein S6 ki

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

The glucosylceramide synthase inhibitor PDMP sensitizes pancreatic cancer cells to MEK/ERK inhibitor AZD-6244

Keywords: هدف پستانداران رپامایسین; MTT; 3-[4,5-dimethylthylthiazol-2-yl]-2,5 diphenyltetrazolium bromide; PDMP; d,l-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol; DMSO; dimethyl sulfoxide; FITC; fluorescein isothiocyanate; mTOR; mammalian target of rapamycin; MAPK; mitogen activat

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

MicroRNA-128 targets myostatin at coding domain sequence to regulate myoblasts in skeletal muscle development

Keywords: هدف پستانداران رپامایسین; CDS; coding domain sequence; DM; differentiation medium; EdU; 5-ethynyl-2′-deoxyuridine; GM; Growth medium; miRNA; microRNA; MSTN; myostatin; mTOR; mammalian target of rapamycin; Myf5; myogenic factor 5; MyHC; myosin heavy chain; MyoG; myogenin; Pax; pa

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Autophagy sustains the survival of human pancreatic cancer PANC-1 cells under extreme nutrient deprivation conditions

Keywords: هدف پستانداران رپامایسین; Autophagy; PANC-1; Extreme nutrient deprivation; Apoptosis; Survival; AMPK; 5′ adenosine monophosphate-activated protein kinase; CQ; chloroquine; LC3; microtubule-associated protein 1A/1B-light chain 3; mTOR; mammalian target of rapamycin; PDAC; pancrea

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Clinical and Genetic Aspects of the Segmental Overgrowth Spectrum Due to Somatic Mutations in PIK3CA

Keywords: هدف پستانداران رپامایسین; CLOVES; Congenital lipomatous overgrowth with vascular, epidermal, and skeletal anomalies; ddPCR; Droplet digital polymerase chain reaction; FFPE; Formalin-fixed and paraffin-embedded; KTS; Klippel-Trénaunay syndrome; LM; Lymphatic malformation; MCAP; Me

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

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