Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants
Keywords: NCX; Ca2+ occlusion; Allosteric sensor; Regulation; Splice variants
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Thapsigargin decreases the Na+- Ca2Â + exchanger mediated Ca2Â + entry in pig coronary artery smooth muscle
Keywords: [Ca2Â +]i; cytosolic Ca2Â +; EGTA; ethyleneglycol bis (2-aminoethyl ether)-N,N,Nâ²,Nâ²-tetraacetic acid; NCX; Na+-Ca2Â +-exchanger; PBS; phosphate buffered saline; NMG; N-methylglucamine; PM; plasma membrane; SER; sarco/endoplasmic reticulum; SERCA; SR
NCX1 and NCX3: Two new effectors of delayed preconditioning in brain ischemia
Keywords: AKT; Neuroprotection; NCX; Preconditioning; Sodium/calcium exchanger;
Leptin-induced Cardiomyocyte Hypertrophy Reveals both Calcium-dependent and Calcium-independent/RhoA-dependent Calcineurin Activation and NFAT Nuclear Translocation
Keywords: BSA; bovine serum albumin; C3; Clostridium botulinum C3 exoenzyme; DTT; dithiothreitol; ELIPA; enzyme linked inorganic phosphate assay; ERK1/2; extracellular signal regulated kinases 1/2; FBS; fetal bovine serum; FK-506; Tacrolimus; HBSS; Hank's balanced
Epac enhances excitation-transcription coupling in cardiac myocytes
Keywords: [Ca2Â +]; calcium concentration; [Ca2Â +]i; intracytoplasmic calcium concentration; [Ca2Â +]n; intranuclear calcium concentration; 2-APB; 2-aminoethoxydiphenyl borate; 8-pCPT; 8-(4-chlorophenylthio)-2-O-methyladenosine-3,5_-cyclic monophosphate; BP; band
Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes
Keywords: α1-AR; alpha1-adrenergic receptor; α1A-WT; wild-type alpha1-adrenergic receptor A subtype; α1AKO; alpha1-adrenergic receptor A subtype single knockout; α1B-WT; wild-type alpha1-adrenergic receptor B subtype; α1BKO; alpha1-adrenergic receptor B subtyp
Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons
Keywords: Neuron; Glutamate; Calcium dysregulation; NMDA receptor; Na+/Ca2+ exchanger; DCD; delayed Ca2+ dysregulation; NMDA; N-methyl-d-aspartate; NMDAR; NMDA receptor; NCX; Na+/Ca2+ exchanger; NCXrev; reverse NCX; PEAQX; ({[(1S)-1-(4-bromophenyl)ethyl]amino}-(2,3
Cardiac specific ATP-sensitive K+ channel (KATP) overexpression results in embryonic lethality
Keywords: KATP; ATP-sensitive K+ channel; αMHC; α myosin heavy chain; DTG; double transgenic; WT; wild type; H&E; Hematoxylin and Eosin; αSMA; α smooth muscle actin; dpc; days post conception; ABC; ATP-binding cassette; STG; single transgenic; PBS; phosphate bu
Metabolic stress, reactive oxygen species, and arrhythmia
Keywords: âΨm; mitochondrial membrane potential; ACE; angiotensin converting enzyme; ADP; adenosine diphosphate; AF; atrial fibrillation; AngII; angiotensin II; AP; action potential; ATP; adenosine-5â²-triphosphate; [Ca2+]i; intracellular Ca2+ concentration; CI
Axonal protection achieved by blockade of sodium/calcium exchange in a new model of ischemia in vivo
Keywords: Ischemia; Stroke; White matter injury; Axonal protection; Sodium/calcium exchanger; ET-1; endothelin-1; NCX; sodium/calcium exchanger;
Ovariectomy enhances SR Ca2+ release and increases Ca2+ spark amplitudes in isolated ventricular myocytes
Keywords: F0; background fluorescence; FDHM; full duration at half maximum amplitude; FWHM; full width at half maximum amplitude; Vh; half-activation voltages; NCX; Na+-Ca2+ exchanger; OVX; ovariectomy; F; peak fluorescence; SR; sarcoplasmic reticulum; K; slope o
Arrhythmogenic mechano-electric heterogeneity in the long-QT syndrome
Keywords: Long-QT syndrome; Electromechanical window; Calcium; Aftercontractions; Torsades de pointes; Ventricular arrhythmia; AP; action potential; APD; action-potential duration; CaMKII; Ca2+/Calmodulin-dependent serine-threonine protein kinase II; CaM; Ca2+/Calm
Lantana macrophylla Schauer (Verbenaceae) ethanolic extract induces activation of ERK1/2 and p38 MAPKs pathway and Ca2+ imbalance in human trophoblasts derived cell lines
Keywords: 1,25-(OH)2D3; vitamin D3; cAMP; cyclic adenosine monophosphate; BSA; bovine serum albumin; [Ca2+]i; intracellular Ca2+ concentration; CaBP28K; calcium binding protein 28K; DMSO; dimethyl sulfoxide; ECL; enhanced chemiluminescence; EGTA; ethylene glycol te
CaMKII regulation of phospholamban and SR Ca2+ load
Keywords: CaMKII; Phospholamban phosphorylation; Sarcoplasmic reticulum; Ryanodine receptors; Acidosis; Ischemia/reperfusion; β-ARS; β1-adrenergic receptor stimulation; CaMKII; Ca2+-calmodulin-dependent protein kinase; cAMP; cyclic adenosine monophosphate; Epac
Arrhythmia triggers in heart failure: The smoking gun of [Ca2+]i dysregulation
Keywords: Calcium alternans; Calcium cycling; Calcium waves; Heart failure; APD; action potential duration; AR; alternans ratio; DAD; delayed afterdepolarization; HF; heart failure; MPT; mitochondrial permeability transition pore; NCX; Na-Ca exchanger; RyR; ryanodi
Calcium fluxes into and out of cytosol in human platelets: Analysis of experimental data
Keywords: NCX; calcium-sodium exchanger; PMCA; plasma membrane calcium ATPase; SERCA; endomembrane calcium ATPase; TG; thapsigargin; TBHQ; 2,5-di-(tert-butyl)-1,4-hydroquinone; Store operated calcium entry; Calcium extrusion; Plasma membrane calcium ATPase; Sodiu
β-Adrenoceptor/PKA-stimulation, Na+-Ca2+ exchange and PKA-activated Clâ currents in rabbit cardiomyocytes: A conundrum
Keywords: Cardiac myocyte; CFTR; NCX; Rabbit atrial myocyte; Rabbit ventricular myocyte; Whole-cell patch-clamp recording;
Ca efflux via the sarcolemmal Ca ATPase occurs only in the t-tubules of rat ventricular myocytes
Keywords: Cardiac; Ventricle; Myocytes; t-tubules; Ca; Extrusion; NCX; Ca ATPase; PKA;
Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis
Keywords: Arrhythmia; Long QT syndrome; Modeling; Systems biology; Ventricular tachycardia; AP; action potential; APD; action potential duration; HERG; human ether-Ã -go-go related gene; NCX; sodium/calcium exchanger; SERCA; sarco/endoplasmic reticulum Ca2+ ATPase;
Sodium-calcium exchanger and lipid rafts in pig coronary artery smooth muscle
Keywords: Ca2+i; cytosolic Ca2+; EGTA; ethyleneglycol bis (2-aminoethyl ether)-N,N,Nâ²,Nâ²-tetraacetic acid; NCX; Na+-Ca2+-exchanger; PBS; phosphate buffered saline; PM; plasma membrane; PMCA; PM Ca2+ pump; SR; sarcoplasmic reticulum; SERCA; SR Ca2+ pump; NCX1;
Mitochondria adjust Ca2+ signaling regime to a pattern of stimulation in salivary acinar cells
Keywords: ACh; acetylcholine; [Ca2+]cyt; cytosolic Ca2+ concentration; ER; endoplasmic reticulum; PM; plasma membrane; InsP3; inositol 1,4,5-trisphosphate; [Ca2+]ER; ER Ca2+ concentration; [Ca2+]mit; mitochondrial Ca2+ concentration; SOC; store-operated channel; SO
A study of the membrane association and regulatory effect of the phospholemman cytoplasmic domain
Keywords: PLM; phospholemman (FXYD1); PLM38-72; a peptide representing residues 38-72 of phospholemman; Mat-8 (FXYD3); mammary tumor protein; CHIF (FXYD4); corticosteroid induced factor; REDOR; rotational-echo double-resonance; SSNMR; solid-state NMR; ITC; isot
Redox signaling in cardiac myocytes
Keywords: AIF; apoptosis-inducing factor; ARC; apoptosis repressor with caspase recruitment domain; CamKII; calmodulin kinase II; CTGF; connective tissue growth factor; EB; embryoid body; ECC; excitation-contraction coupling; ER; endoplasmic reticulum; ES; embryo
Targeted GLUT-4 deficiency in the heart induces cardiomyocyte hypertrophy and impaired contractility linked with Ca2+ and proton flux dysregulation
Keywords: GLUT4 knockout; Cardiomyocyte; Calcium homeostasis; Myocardial insulin resistance; pH regulation; Excitation-contraction coupling; NCX; NHE;
Polyol pathway impairs the function of SERCA and RyR in ischemic-reperfused rat hearts by increasing oxidative modifications of these proteins
Keywords: AR; aldose reductase; ARI; aldose reductase inhibitor; ATP; adenosine triphosphate; E[Ca2+]i; electrically induced calcium transient; GAPDH; glyceraldehydes-3-phosphate dehydrogenase; GSH; glutathione; HR; heart rate; [Ca2+]i; intracellular calcium; I/R;
Ionic storm in hypoxic/ischemic stress: Can opioid receptors subside it?
Keywords: [Ca2+]i; intracellular Ca2+ concentrations; [Ca2+]o; extracellular Ca2+ concentrations; [K+]e; extracellular K+ concentrations; [K+]i; intracellular K+ concentrations; [Na+]i; intracellular Na+ concentrations; [Na+]o; extracellular Na+ concentrations; AMP
Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology
Keywords: PP1; type 1 protein phosphatase; Ca; Calcium; PP1c; type 1 protein phosphatase catalytic subunit; I-1; inhibitor-1; I-2; inhibitor-2; SR; sarcoplasmic reticulum; LTCC; L-type Ca channel; RyR; ryanodine receptor; SERCA2a; SR/ER-Ca ATPase 2a; PLN; phosphola
A key role for dense granule secretion in potentiation of the Ca2+ signal arising from store-operated calcium entry in human platelets
Keywords: Platelet; Store-operated calcium entry; Dense granule; Sodium–calcium exchanger; NCX; NCKX; KB-R7943; SN-6
Characterization of somatic Ca2+ clearance mechanisms in young and mature hippocampal granule cells
Keywords: Calcium; Clearance; Development; Adult neurogenesis; NCX; SERCA; PMCA; Mitochondria; Hippocampus; Granule cell
Development and evolution of the subpallium
Keywords: AEP; peduncular region; DC; dorsal cortex; DP; dorsal pallium; DVR; dorsal ventricular ridge; LGE; lateral ganglionic eminence; LP; lateral pallium; MGE; medial ganglionic eminence; NCX; neocortex; Pa; pallium; PSB; pallium-subpallium boundary; POC; com
Ryanodine receptor-mediated arrhythmias and sudden cardiac death
Keywords: Ryanodine receptor; Cardiac arrhythmia; Sudden cardiac death; Heart failure; Catecholaminergic polymorphic ventricular tachycardia; AP; action potential; ARVD2; arrhythmogenic right ventricular cardiomyopathy type 2; CaMKII; Ca2+/calmodulim-dependent prot
Regulation of cardiac excitation and contraction by p21 activated kinase-1
Keywords: Protein phosphatase 2A; L-type Ca2+-channel; Sarcomeric protein phosphorylation; Ryanodine receptor; AC; denylate cyclase; Ad; adenovirus; BK channel; Ca2+-activated K+ currents; B(PR55); PP2A regulatory subunits; Bâ²(PR61); PP2A regulatory subunits; Bâ
Extracellular calcium as an integrator of tissue function
Keywords: CaR; calcium sensing receptor; Cao2+; extracellular calcium; GPCR; G protein-coupled receptor; Cai2+; intracellular calcium; NCX; Na+/Ca2+ exchanger; PTH; parathyroid hormone; PMCA; plasma membrane Ca2+ ATPase; 1,25(OH)2D; vitamin D; Extracellular calcium
Nitric oxide-donating aspirin (NCX 4016) inhibits neointimal thickening in a pig model of saphenous vein-carotid artery interposition grafting: A comparison with aspirin and morpholinosydnonimine (SIN-1)
Keywords: 16; 23; ASA; aspirin; CABG; coronary artery bypass graft; NCX; nitric oxide-donating aspirin; NO; nitric oxide; PCNA; proliferating cell nuclear antigen; SIN-1; morpholinosydnonimine; VSMC; vascular smooth muscle cell;
Involvement of Na+-Ca2+ exchanger on metabotropic glutamate receptor 1-mediated [Ca2+]i transients in rat cerebellar Purkinje neurons
Keywords: Na+-Ca2+ exchanger; NCX; metabotropic glutamate receptor 1; mGluR1; cerebellar Purkinje neuron; 3,5-dihydroxyphenylglycine; DHPG; AMPAR; AMPA receptor; AS-oligos; antisense oligodeoxynucleotides; BSA; bovine serum albumin; [Ca2+]i; intracellular Ca2+ co
The role of the Na+/Ca2+ exchanger (NCX) in neurons following ischaemia
Keywords: NCX; Na+/Ca2+ exchanger; Ischaemia; Calcium; Excitotoxicity
Postnatal developmental changes in Ca2+ homeostasis in supraoptic magnocellular neurons
Keywords: Calcium clearance; NCX; NCKX; SERCA; Development; Supraoptic magnocellular neuron;
Ca2+ extrusion in aged smooth muscle cells
Keywords: Calcium signals; Smooth muscle; PMCA; NCX; SERCA; Guinea pig
Functional expression of the Na+/Ca2+ exchanger in the embryonic mouse heart
Keywords: NCX; Cardiac development; Electrophysiology; Embryonic heart; Calcium;
A key role for reverse Na+/Ca2+ exchange influenced by the actin cytoskeleton in store-operated Ca2+ entry in human platelets: Evidence against the de novo conformational coupling hypothesis
Keywords: NCX; Platelets; Store-operated calcium entry; KB-R7943; SN-6
Mitochondria buffer NCX-mediated Ca2+-entry and limit its diffusion into vascular smooth muscle cells
Keywords: Sarcoplasmic reticulum; Aequorin; NCX; Smooth muscle; Purinergic receptors
Estrogen prevents glutamate-induced apoptosis in C6 glioma cells by a receptor-mediated mechanism
Keywords: calcium; calpain; caspase; estrogen receptor; glia; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; APV; dl-2-amino-5-phosphonopentanoic acid; BSA; bovine serum albumin; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; DAN; dantrolene; DMSO; dime
Synthesis and structure-activity relationships of 6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide derivatives as a novel class of NCX inhibitors: a QSAR study
Keywords: Sodium-calcium exchanger; NCX; Traditional QSAR; Anti-arrhythmias;
Calcium channels, transporters and exchangers in placenta: a review
Keywords: ATP; adenine triphosphate; BBM; brush-border membrane; BLM; basal plasma membrane; Ca2+; calcium; CaBP; Ca2+-binding protein; CaMK; calmodulin kinase; CaT; Ca2+ transporter; CaT-L; Ca2+ transporter like; CCE; capacitative Ca2+ entry; CIF; Ca2+-influx fact
Synthesis and structure-activity relationships of benzyloxyphenyl derivatives as a novel class of NCX inhibitors: effects on heart failure
Keywords: Sodium-calcium exchanger; NCX; Transporter; Anti-arrhythmias;
Rapid turnover of the “functional” Na+-Ca2+ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach
Keywords: Sodium-calcium exchange; NCX; Antisense oligodeoxynucleotides; Cardiac myocyte; Heart; Intracellular calcium; Calcium transport; Caged calcium; Sf9 cells;
Effects of Na+-Ca2+ exchanger activity on the α-amino-3-hydroxy-5-methyl-4-isoxazolone-propionate-induced Ca2+ influx in cerebellar Purkinje neurons
Keywords: Na+-Ca2+ exchanger; AMPA receptor; Purkinje neuron; antisense oligodeoxynucleotides; bepridil; KB-R7943; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolone-propionate; AS-oligos; antisense oligodeoxynucleotides; BSA; bovine serum albumin; [Ca2+]i; intracellu
Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats
Keywords: Cardiomyopathy; Type 2 diabetes; Abnormal Ca2+ regulation; SERCA; NCX;
Molecular cloning and characterization of two novel truncated isoforms of human Na+/Ca2+ exchanger 3, expressed in fetal brain
Keywords: aa; amino acid(s); bp; base pair(s); cDNA; DNA complementary to RNA; DD-PCR; differential display-polymerase chain reaction; dNTP; deoxyribonucleoside triphosphate; EST; expressed sequence tag; EtdBr; ethidium bromide; G3PDH; glyceraldehyde 3-phosphate de
Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor
Keywords: Sodium–calcium exchanger; NCX; Anti-arrhythmics