دانلود مقالات ISI درباره Nhej + ترجمه فارسی

Strategies for controlling CRISPR/Cas9 off-target effects and biological variations in mammalian genome editing experiments

Keywords: CRISPR; clustered regularly interspaced short palindromic repeats; gRNA; guide RNA; OTE; off-target effects; KO; knock out; NHEJ; non-homologous end joining; KI; knock in; HDR; homology directed repair; GOI; gene of interest; LOI; locus of interest; iPSC;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

A novel duplication downstream of BMP2 in a Chinese family with Brachydactyly type A2 (BDA2)

Keywords: BD; brachydactyly; BDA2; Brachydactyly type A2; BMP; bone morphogenetic protein; BMPR1B; bone morphogenetic protein receptor type-1B; CNV; copy number variant; GDF; growth differentiation factor; LCR; low copy repeat; NAHR; non-allelic homologous recombin

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Integrating plant and animal biology for the search of novel DNA damage biomarkers

Keywords: ARP; actin related protein; ASK; Arabidopsis SPK1-like; At; Arabidopsis thaliana; ATAF; arabidopsis transcription activation factor; ATM; ataxia telangiectasia mutated; ATR; ATM and Rad3-related; ATRIP; ATR-interacting protein; BARD; BRCA1-associated RING

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

Novel noncontiguous duplications identified with a comprehensive mutation analysis in the DMD gene by DMD gene-targeted sequencing

Keywords: BMD; Becker muscular dystrophy; DMD; Duchenne muscular dystrophy; FoSTeS; Fork Stalling and Template Switching; FTHL17; ferritin heavy chain like 17; MLPA; multiplex ligation dependent probe amplification; MMBIR; microhomology-mediated break-induced repli

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

Mutational game changer: Chromothripsis and its emerging relevance to cancer

Keywords: SAC; spindle assembly checkpoint; APOBEC; apolipoprotein B mRNA-editing catalytic subunit; SNP; single-nucleotide polymorphism; array-CGH; comparative genomic hybridization; CLTP; chromothripsis-like pattern; SKY; spectral karyotyping; FISH; fluorescent i

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

DNA repair mechanisms in response to genotoxicity of warfare agent sulfur mustard

Keywords: ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3 related; BER; base excision repair; Cdc25; cell division cycle 25; CDKs; cyclin-dependent kinases; CEES; 2-chloroethyl ethyl sulphide; ChK1; checkpoint kinase 1; Chk2; checkpoint kina

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

Diagnosis and therapy with CRISPR advanced CRISPR based tools for point of care diagnostics and early therapies

Keywords: CRISPR; clustered regularly interspaced short palindromic repeats; Cas; CRISPR-associated protein; crRNA; CRISPR RNA; SgRNA; single guide RNA; tracrRNA; trans-activating RNA; PAM; protospacer-adjacent motif; DSB; DNA double strand break; SHERLOCK; Specifi

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Highly efficient genome editing by homology-directed repair using Cas9 protein in Ceratitis capitata

Keywords: ssODN-mediated homology-directed repair; CRISPR-Cas9 ribonucleoprotein complexes; Mediterranean fruit fly; Tephritids; Sterile insect technique; BFP; blue fluorescent protein; bp; base pair(s); Cas; CRISPR associated; CRISPR; Clustered Regularly Interspac

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Inheritance of co-edited genes by CRISPR-based targeted nucleotide substitutions in rice

Keywords: Acetolactate synthase (ALS); Activation-induced cytidine deaminase (AID); Herbicide tolerance; Rice; Selectable marker-free (SMF); Target-AID; Targeted nucleotide editing; CRISPR/Cas9; clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR as

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Efficient transgene insertion in a pseudorabies virus vector by CRISPR/Cas9 and marker rescue-enforced recombination

Keywords: ASFV; African swine fever virus; BAC; bacterial artificial chromosome; Cas9; CRISPR associated protein 9; CRISPR; clustered regularly interspaced short palindromic repeats; DSB; double strand break; EGFP; enhanced green fluorescent protein; FBS; fetal bov

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

The potential and challenges of CRISPR-Cas in eradication of hepatitis B virus covalently closed circular DNA

Keywords: CHB; chronic hepatitis B; HBV; hepatitis B virus; NA; nucleos(t)ide analogue; cccDNA; covalently closed circular DNA; guide RNA; gRNA; NTCP; sodium taurocholate cotransporting polypeptide; RC-DNA; relaxed circular DNA; pgRNA; pregenomic RNAs; HBsAg; HBV s

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Co-located hAT transposable element and 5S rDNA in an interstitial telomeric sequence suggest the formation of Robertsonian fusion in armored catfish

Keywords: 2n; diploid number; a; acrocentric; bp; base pair; CTAB; cetyltrimethylammonium bromide; DAPI; 4′,6-diamidino-2-phenylindole; dNTPs; deoxyribonucleoside triphosphate; DT; dysfunctional telomere; EBRs; evolutionary breakpoint regions; FISH; fluorescence

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

CRISPR-Cas based antiviral strategies against HIV-1

Keywords: CRISPR-Cas; HIV-1; dCas9; Virus escape; NHEJ; Combination therapy; Latency;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Irradiation by γ-rays reduces the level of H3S10 phosphorylation and weakens the G2 phase-dependent interaction between H3S10 phosphorylation and γH2AX

Keywords: Mass spectrometry; Histones H3 and H4; γH2AX; DNA damage; Embryonic stem cells; Epigenetics; FLIM; Fluorescence lifetime image microscopy; FRET; Förster resonance energy transfer; H3; histone H3; H4; histone H4; me1; monomethylated histones; me2; dimeth

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling

Keywords: SAHA; Suberoylanilide hydroxamic acid; AMPK; AMP-dependent protein kinase; HDAC; histone deacetylase; HDACi; Histone deacetylase inhibitor; mTOR; Mechanistic target of rapamycin; NHEJ; Non-homologous end joining; TSA; Trichostatin A; H3K36; Histone H3 lys

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Uncharacterized ORF HUR1 influences the efficiency of non-homologous end-joining repair in Saccharomyces cerevisiae

Keywords: DDA; DNA damage array; DSBs; DNA double stranded breaks; GI; genetic interaction; HR; homologous recombination; HU; hydroxyurea; MMEJ; micro-homology mediated end joining; NHEJ; non-homologous end joining; PPI; protein-protein interaction; c-NHEJ; classic

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy

Keywords: PARP; poly (ADP-ribose) polymerase; TMZ; temozolomide; BER; base-excision repair; MGMT; O-6-methylguanine-DNA methyltransferase; NHEJ; non-homologous end joining; HR; homologous recombination; 3-AB; 3-aminobenzamide; MTIC; 5-(3-methyltriazen-1-yl)imidazol

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

ROS signalling in the biology of cancer

Keywords: AEJ; alternative end joining; ALL; acute lymphoblastic leukaemia; AML; acute myeloid leukaemia; Apaf-1; apoptotic protein activating factor 1; APL; acute promyelocytic leukaemia; ASK1; apoptosis signal regulating kinase 1; Bcr-Abl; breakpoint cluster-Abel

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance

Keywords: ABCB1; ATP-binding cassette sub-family B member 1; AML; acute myeloid leukaemia; AMPK; adenosine monophosphate-activated protein kinase; ATM; Ataxia-telangiectasia mutated; AURKA; aurora kinase A; BER; base excision repair; Bim; B-cell lymphoma 2 interact

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders

Keywords: Ataxia-telangiectasia; Cernunnos-XLF deficiency; DNA repair disorders; DNA ligase IV deficiency; hematopoietic stem cell transplantation; Nijmegen breakage syndrome; aGvHD; Acute graft-versus-host disease; AT; Ataxia-telangiectasia; ATG; Anti-thymocyte gl

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2018 سفارش ترجمه

A multifaceted role for MOF histone modifying factor in genome maintenance

Keywords: MOF; DNA DSB; H4K16ac; NHEJ; HR; Oncogenesis;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Extremely low frequency electromagnetic field in combination with β-Lapachone up-regulates the genes of non-homologous end joining

Keywords: β-Lapachone; Electromagnetic field; Morphine; NHEJ; Gene expression;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Genome-scale CRISPR pooled screens

Keywords: Genome engineering; Genetic screens; CRISPR; Cas9; Noncoding; Cancer; RNAi; RNA interference; CRISPR; clustered regularly interspaced short palindromic repeats; sgRNA; single-guide RNA; DSB; double-strand break; NHEJ; non-homologous end-joining; PCR; poly

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Different profiles of the mRNA levels of DNA repair genes in MCF-7 and SH-SY5Y cells after treatment with combination of cisplatin, 50-Hz electromagnetic field and bleomycin

Keywords: Electromagnetic field; Cisplatin; Bleomycin; DNA repair; NHEJ; NER;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewRegulation of repair pathway choice at two-ended DNA double-strand breaks

Keywords: DSB; NHEJ; HR; Two-ended DSB; BRCA1; 53BP1;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Polμ deficiency induces moderate shortening of P53−/− mouse lifespan and modifies tumor spectrum

Keywords: DNA polymerase mu; Polμ; p53; NHEJ; DSB; Genomic instability; Sarcoma; Lymphoma;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

An efficient system for deletion of large DNA fragments in Escherichia coli via introduction of both Cas9 and the non-homologous end joining system from Mycobacterium smegmatis

Keywords: CRISPR; NHEJ; Genome editing; Large fragment deletion; E. coli;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Measurement of DNA damage in peripheral blood by the γ-H2AX assay as predictor of colorectal cancer risk

Keywords: DSBs; DNA double-strand breaks; PBLs; peripheral blood lymphocytes; CRC; colorectal cancer; IR; ionizing radiation; ORs; odds ratios; BMI; body mass index; HR; homologous recombination; NHEJ; non-homologous end joining; Gamma H2AX; Colorectal cancer risk;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Poetry in motion: Increased chromosomal mobility after DNA damage

Keywords: HR; homologous recombination; DSB; double strand break; HS; homology search; MMS; methylmethane sulfonate; NHEJ; non-homologous end joining; SCE; sister chromatid exchange; PCNA; proliferating cell nuclear antigen; SDSA; synthesis dependent strand anneali

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

A two-plasmid inducible CRISPR/Cas9 genome editing tool for Clostridium acetobutylicum

Keywords: aTc; anhydrotetracycline; CRISPR; Clustered regularly interspaced short palindromic repeats; Cas; CRISPR-associated proteins; Cas9n; Cas9 nickase; DSB; Double-strand break; gDNA; genomic DNA; gRNA; guide RNA; HR; Homologous recombination; NHEJ; Non-homolo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

The RAG recombinase: Beyond breaking

Keywords: V(D)J recombination; RAG recombinase; DNA damage response; NHEJ; Adaptive immunity;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome

Keywords: CPC; choroid plexus carcinoma; DSBs; double-strands breaks; LFS; Li-Fraumeni syndrome; mFISH; multicolour fluorescence in-situ hybridization; NHEJ; non-homologous end-joining; SEM; scanning electron microscopy; TEM; transmission electron microscopy; γH2A

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

The impact of the IGF-1 system of cancer cells on radiation response - An in vitro study

Keywords: IGF-1R; insulin-like growth factor 1 receptor; SF; surviving fractions; IGF-1R/KR; kinase-deficient IGF-1R; Caco-2-KR4; IGF-1R/KR clone number 4; IRS-1; insulin receptor substrate 1; HRR; homologous recombination repair; NHEJ; non-homologous end joining;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Taming Tricky DSBs: ATM on duty

Keywords: ATM; ataxia telangiectasia mutated; DSB; double strand breaks; DDR; DNA damage response; HR; homologous recombination; NHEJ; non-homologous end joining; PI3K; phosphoinositide 3-kinase; RNA pol II; RNA polymerase II; TAD; topologically associated domain;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Multiple repair pathways mediate cellular tolerance to resveratrol-induced DNA damage

Keywords: HR; homologous recombination; TLS; translesion DNA synthesis; SSBR; single-strand break repair; BER; base excision repair; NER; nucleotide excision repair; NHEJ; non-homologous end joining; PPR; postreplication repair; DSBs; double- strand breaks; WT; wil

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Control of DNA end resection by yeast Hmo1p affects efficiency of DNA end-joining

Keywords: High mobility group protein; DNA end resection; Alternate end-joining; Plasmid end-joining; NHEJ;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

CtIP/Ctp1/Sae2, molecular form fit for function

Keywords: MRN; Mre11-Rad50-Nbs1; HR; homologous recombination; THDD; tetrameric helical dimer of dimers; DSB; double-strand break; IR; ionizing radiation; NHEJ; non-homologous DNA end joining; MMEJ; microhomology-mediated end joining; IDR; intrinsically disordered

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticlemiR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis

Keywords: microRNAs; Prostate cancer; Radiosensitivity; EMT; EGFR; CHK1; Checkpoint kinase 1; EGFR; Epidermal growth factor receptor; EMT; Epithelial-to-mesenchymal transition; HR; Homologous recombination; LIN7C; Lin-7 homolog C; miRNA; microRNA; NHEJ; Non homolog

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Histone ubiquitination in the DNA damage response

Keywords: DSB; DNA double strand breaks; HR; homologous recombination; NHEJ; non homologous end-joining; PTM; post-translational modification; DUB; deubiquitinating enzyme; USP; ubiquitin specific protease; PRC; polycomb repressive complex; RING; really interesting

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA

Keywords: CRISPR; clustered regularly interspaced short palindromic repeats; CAS9; CRISPR associated protein; gRNA; guide RNA; PAM; protospacer adjacent motif; RNP; ribonucleoprotein; HDR; homology directed repair; hESCs; human embryonic stem cells; NHEJ; non-homol

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs)

Keywords: Ku; DNA-PK; NHEJ; Protein-DNA interaction; Protein-protein interaction;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes

Keywords: εAde; 1,N6-ethenoadenine; εCyt; 3,N4-ethenocytosine; 1; N2- εGua, 1,N2-ethenoguanine; BER; base excision repair; NER; nucleotide excision repair; NIR; nucleotide incision repair; HR; homologous recombination; NHEJ; non-homologous end joining; LPO; lipi

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD)

Keywords: 9-1-1 complex; complex of Rad9 Rad1 and Hus1 proteins; A2E; N-retinylidene-N-retinylethanol-amine; AtRal; all-trans retinal; AMD; age-related macular degeneration; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATM; ataxia-telangiectasia

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management

Keywords: BER; base excision repair; NER; nucleotide excision repair; MMR; mismatch repair; HR; homologous recombination; NHEJ; non-homologous end joining; PTMs; post-translational modifications; DNA damage; Base excision repair BER; DNA pathway crosstalk; DNA repa

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewTranscription and DNA Damage: Holding Hands or Crossing Swords?

Keywords: DSBs; DNA double-strand breaks; DDR; DNA damage response; MRN; MRE11-RAD50-NBS1; ATM; ataxia telangiectasia mutated; MDC1; mediator of DNA-damage checkpoint; 53BP1; p53-binding protein; NHEJ; non-homologous end joining; ncRNA; non-coding RNA; HR; homo

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Role for RIF1-interacting partner DDX1 in BLM recruitment to DNA double-strand breaks

Keywords: BLM; Bloom syndrome helicase; DDX1; DEAD Box 1; DSB; double strand break; Gy; gray; HR; homologous recombination; IR; ionizing radiation; NHEJ; non-homologous end joining; RIF1; Rap1-interacting factor 1; RNase; ribonuclease; DNA double strand break repai

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Genetic variants of the DNA repair genes from Exome Aggregation Consortium (EXAC) database: significance in cancer

Keywords: AP; Apurinic/Apyrimidinic; BER; Base excision repair; dbSNP; Single Nucleotide Polymorphism database; DNA; Deoxyribonucleic acid; DSB; Double-strand break; ExAC; Exome Aggregation Consortium; FA; ;Fanconi Anemia; GGR; Global Genomic Repair; GWAS; Genome W

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

In vivo genome editing as a potential treatment strategy for inherited retinal dystrophies

Keywords: Genome editing; In vivo; Retina; CRISPR-Cas; TALEN; AAV; Endonucleases; NHEJ; HDR; MMEJ;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2017 سفارش ترجمه

CRISPR system in filamentous fungi: Current achievements and future directions

Keywords: CRISPR; clustered regularly interspaced short palindromic repeats; NHEJ; non-homologous end joining; HDR; high-fidelity homology-directed repair; ZFN; zinc finger nucleases; TALEN; transcription activator-like effector nucleases; tef1; translation-elongat

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2017 سفارش ترجمه

Exploring the potential of genome editing CRISPR-Cas9 technology

Keywords: Cas; CRISPR-associated proteins; cccDNA; covalently closed circular DNA; CCR5; C-C chemokine receptor type 5; CHO; Chinese hamster ovary; CRISPRs; clustered regularly interspaced short palindromic repeats; CRISPRa; CRISPR activation; CRISPRi; CRISPR inter

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2017 سفارش ترجمه