Calorie restriction (CR) reduces age-dependent decline of non-homologous end joining (NHEJ) activity in rat tissues
Keywords: Calorie restriction; NHEJ; Aging; XRCC4;
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The role of SNM1 family nucleases in etoposide-induced apoptosis
Keywords: Apoptosis; SNM1A; APOLLO; ARTEMIS; NHEJ; DT40
Effects of X-irradiation on mitochondrial DNA damage and its supercoiling formation change
Keywords: LET; liner energy transfer; CD; common deletion; mtDNA; mitochondrial DNA; RBE; relative biological effect; OER; oxygen enhance ratio; DSBs; double strand breaks; SSBs; single strand breaks; ROS; reactive oxygen species; Cp; cross point; NER; nucleotide e
Histone deacetylase inhibitor sodium butyrate enhances cellular radiosensitivity by inhibiting both DNA nonhomologous end joining and homologous recombination
Keywords: DSB; double strand break; FACS; fluorescence activated cell sorting; HAT; histone acetyltransferase; HDAC; histone deacetylase; HR; homologous recombination; NHEJ; nonhomologous end joining; Sodium butyrate; γ-Irradiation; Histone acetylation; DNA nonhom
Kinetic analysis of DNA double-strand break repair pathways in Arabidopsis
Keywords: Recombination; DSB; DNA repair; NHEJ; g-H2AX; Kinetics;
Topoisomerase IIβ associates with Ku70 and PARP-1 during double strand break repair of DNA in neurons
Keywords: PARP-1; Ku70; Topoisomerase IIβ; Neurons; DSB repair; Peroxide; NHEJ
Clustered DNA lesion repair in eukaryotes: Relevance to mutagenesis and cell survival
Keywords: DSB; double strand break; MDS; multiply damaged sites; SSB; single strand break; LET; linear energy transfer; BER; base excision repair; NER; nucleotide excision repair; HR; homologous recombination; NHEJ; non-homologous end-joining; PRR; post-replication
Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation
Keywords: IR; ionizing radiation; DSB; double-strand break; LET; linear energy transfer; EGFP; enhanced green fluorescent protein; NHEJ; non-homologous end-joining; HR; homologous recombination; WRN; Werner syndrome protein; Clustered DNA damage; Ionizing radiation
Choosing the right path: Does DNA-PK help make the decision?
Keywords: a-NHEJ; alternative non-homologous end joining; B-NHEJ; backup non-homologous end joining; c-NHEJ; classical non-homologous end joining; DNA-PK; DNA-dependent protein kinase; DNA-PKcs; DNA-dependent kinase catalytic subunit; DSB; double strand break; HR;
Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining
Keywords: Coilin; Ku70; Ku80; NHEJ
The bridge-region of the Ku superfamily is an atypical zinc ribbon domain
Keywords: NHEJ; Zinc finger; Zinc ribbon; Protein flexibility; Segment-swapping;
Defending the end zone: Studying the players involved in protecting chromosome ends
Keywords: Telomere; Shelterin; DNA damage response; NHEJ;
Highly efficient gene targeting in Penicillium chrysogenum using the bi-partite approach in Δlig4 or Δku70 mutants
Keywords: Gene targeting; P. chrysogenum; Filamentous fungi; NHEJ; Bi-partite
Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair
Keywords: Artemis; DNA end processing; NHEJ; DNA-PK
Srs2: The “Odd-Job Man” in DNA repair
Keywords: DSB; double-strand break; HR; homologous recombination; NHEJ; non-homologous end joining; PRR; post-replication repair; SDSA; synthesis-dependent single-strand annealing; HU; hydroxyurea; MMS; methyl methanesulfonate; dHJ; double Holliday junction; HJ; Ho
Efficient repair of DNA double-strand breaks in malignant cells with structural instability
Keywords: DSB; double-strand break; GCRs; gross chromosomal rearrangements; NHEJ; non-homologous end joining; DNA double-strand break (DSB); Chromosomal rearrangement; I-SceI; Ovarian cancer;
Fission yeast telomeres forecast the end of the crisis
Keywords: ATM; ataxia telangiectasia mutated (Tel1 in budding yeast); ATR; ATM and Rad3 Related; ChIP; chromatin immuno-precipitation; DDR; DNA damage response; DSB; double strand break; dsDNA; double stranded DNA; HR; homologous recombination; NHEJ; non-homologous
Variant base excision repair proteins: Contributors to genomic instability
Keywords: BER; base excision repair; ROS; reactive oxygen species; SAM; S-adenosylmethionine; APE1; apurimidinic endonuclease I; MTH; MutT homolog; OGG1; DNA glycosylase 8-oxoguanine glycosylase; FapyG; 2,6-diamino-4-hydroxy-5-formamidopyrimidine; 5-meC; 5-methylcy
Genetic recombination pathways and their application for genome modification of human embryonic stem cells
Keywords: Human embryonic stem cells; Pluripotent; iPS cells; Gene targeting; Homologous recombination; HR; Non-homologous end joining; NHEJ; Site-specific recombination; DNA transposition
DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis
Keywords: Nonhomologous DNA end joining; NHEJ; Double-strand DNA break repair; V(D)J recombination; Single-stranded DNA endonuclease
Some unsolved problems and unresolved issues in radiation cytogenetics: A review and new data on roles of homologous recombination and non-homologous end joining
Keywords: Chromosomal aberrations; Ionizing radiation; NHEJ; HRR; Chromatin organization and structure
Genomic rearrangements in inherited disease and cancer
Keywords: aCGH; array comparative genomic hybridization; BIR; break-induced replication; CNV; copy number variation; CNM; copy number mutation; D-loop; displacement loop; DSB; double-strand break; FoSTes; fork stalling and template switching; HJ; Holliday junction;
Animal models of mitochondrial DNA transactions in disease and ageing
Keywords: mtDNA replication; mtDNA repair and recombination; Mitochondrial transcription; Animal models; Mouse; Drosophila; mtDNA; mitochondrial DNA; OXPHOS; oxidative phosphorylation system; ROS; reactive oxygen species; COX; cytochrome c oxidase; PD; Parkinson'
Roles of Werner syndrome protein in protection of genome integrity
Keywords: γ-H2AX; phosphorylated histone H2AX; 4-NQO; 4-nitroquinoline 1-oxide; 5-OHdC; 5-hydroxycytidine; 5-OHU; 5-hydroxyuracil; 8-oxodA; 8-oxoadenine; 8-oxodG; 8-oxoguanine; ALT; alternative lengthening of telomeres; APE1; apurinic/apyrimidinic endonuclease 1;
DNA ligase IV as a new molecular target for temozolomide
Keywords: TMZ; DSB; NHEJ; HR; Lig4
DNA double-strand breaks: Their production, recognition, and repair in eukaryotes
Keywords: DSB; γH2AX; DNA repair; HR; NHEJ
Lithium chloride protects retinal neurocytes from nutrient deprivation by promoting DNA non-homologous end-joining
Keywords: Lithium chloride; Retinal neuron; Neuroprotection; NHEJ; Ligase IV
Rapid repair of DNA double strand breaks in Arabidopsis thaliana is dependent on proteins involved in chromosome structure maintenance
Keywords: DSB; DNA double strand break; SSB; DNA single strand break; NHEJ; non-homologous end-joining; C-NHEJ; classical-NHEJ; SMC; structural maintenance of chromosomes; ROS; reactive oxidative species; UV; ultraviolet; IR; ionizing radiation; AtKU80; AtRAD21.1;
A histidine in the β-CASP domain of Artemis is critical for its full in vitro and in vivo functions
Keywords: Artemis; HCA; Metallo-β-lactamase; NHEJ; SCID;
Electron microscopy of Xrcc4 and the DNA ligase IV–Xrcc4 DNA repair complex
Keywords: Xrcc4; DNA ligase IV; Lig4; DNA repair; NHEJ; Electron microscopy
Nonhomologous end-joining deficiency allows large chromosomal deletions to be produced by replacement-type recombination in Aspergillus oryzae
Keywords: Aspergillus; Aspergillus oryzae; Aspergillus sojae; Large deletion; Chromosomal deletion; Nonhomologous end-joining; NHEJ; Replacement-type recombination; Recombination; Targeting; Homologous recombination; Chromosomal deletion; ku70; ligD
Mechanism of cell killing after ionizing radiation by a dominant negative DNA polymerase beta
Keywords: IR; ionizing radiation; DSB; double strand break; SSB; single strand break; BER; base excision repair; SSBR; single strand break repair; polβDN; dominant negative DNA polymerase β; AP; apurinic/apyrimidinic; polβ; DNA polymerase beta; dRP; deoxyribose
Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O6-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs
Keywords: Apoptosis; DNA double-strand breaks; Aberrations; SCEs; Brca2; XRCC2; NHEJ; MGMT; Homologous recombination; Temozolomide
Therapeutic options for triple-negative breast cancers with defective homologous recombination
Keywords: ABC; ATP-binding cassette; APC; Adenomatous, polyposis coli; ATM; Ataxia telangiectasia mutated; ATR; ATM and Rad3-related; BER; base-excision repair; BRCA1; Breast cancer susceptibility gene 1; BRCA2; Breast cancer susceptibility gene 2; CGH; Comparative
A Nonhomologous End-joining Pathway Is Required for Protein Phosphatase 2A Promotion of DNA Double-Strand Break Repair
Keywords: NHEJ; nonhomologous end-joining; DSB; DNA double-strand break; PP2A/C; protein phosphatase 2A catalytic subunit; small T; the SV40 small tumor antigen; PFGE; pulsed-field gel electrophoresis; HA; hemagglutinin; siRNA; small interfering RNA; RNAi; RNA inte
The type and yield of ionising radiation induced chromosomal aberrations depend on the efficiency of different DSB repair pathways in mammalian cells
Keywords: Chromosomal aberrations; DNA repair; HRR; NHEJ; DNA DSBs; Ionising radiations
Ku, Artemis, and ataxia-telangiectasia-mutated: Signalling networks in DNA damage
Keywords: AT; ataxia-telangiectasia; ATM; ataxia-telangiectasia-mutated; ATR; ataxia-telangiectasia and Rad3-related; DNA-PK; DNA-dependent protein kinase; DNA-PKcs; catalytic subunit of DNA-dependent protein kinase; DSBs; double-strand breaks; ROS; reactive oxygen
Interacting proteins Rtt109 and Vps75 affect the efficiency of non-homologous end-joining in Saccharomyces cerevisiae
Keywords: DNA repair; Novel gene function; NHEJ; Double-stranded break; Protein–protein interaction; Homologous recombination
Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells
Keywords: Neuroblastoma; DSB repair; NHEJ; Genomic instability; Microarray; XRCC4
Organization and evolution of mitochondrial gene clusters in human
Keywords: NEMP; nuclear-encoded mitochondrial protein; ppNEMP; processed pseudogene of NEMP; mtDNA; mitochondrial DNA; NHEJ; nonhomologous end-joining; DSB; double-strand breaks; Endosymbiosis; Evolutionary pocket; Gene cluster; Nuclear-encoded mitochondrial protei
Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo
Keywords: TR; T cell receptor; Ig; immunoglobulin; RSS; recombination signal sequence; SE; signal end; CE; coding end; SJ; signal joint; CJ; coding joint; NHEJ; non-homologous end joining; DSB; double strand break; TdT; terminal nucleotidyl transferase; DNA-PK; DNA
Cadmium inhibits non-homologous end-joining and over-activates the MRE11-dependent repair pathway
Keywords: Cadmium; DSB repair; NHEJ; DNA-PK; MRE11
Distinctive differences in DNA double-strand break repair between normal urothelial and urothelial carcinoma cells
Keywords: NHEJ; Microhomology-mediated end-joining (MMEJ); Microhomology; Urothelial cancer; Deletion; Processing
Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship
Keywords: CBDCA; carboplatin; CT; computed tomography; EGFR; epidermal growth factor receptor; FDA; Food and Drug Administration; GyE; Gy equivalent; LTLC; long-term lung cancer; NHEJ; nonhomologous endjoining; NSCLC; non-small cell lung cancer; PET; positron emiss
A novel variable number of tandem repeats (VNTR) polymorphism containing Sp1 binding elements in the promoter of XRCC5 is a risk factor for human bladder cancer
Keywords: DSB; double-strand break; EMSA; electrophoretic mobility shift assay; NHEJ; non-homologous end joining; PCR; polymerase chain reaction; SDS; sodium dodecyl sulfate; VNTR; variable number of tandem repeats; XRCC5; X-ray repair cross-complementing 5; Bladde
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation
Keywords: NHEJ; APLF; FHA domains; ATM; Phosphorylation; CK2
Low joining efficiency and non-conservative repair of two distant double-strand breaks in mouse embryonic stem cells
Keywords: DSB repair; Genome rearrangements; DNA junctions; NHEJ; Mouse ES cells
Mutations to Ku reveal differences in human somatic cell lines
Keywords: NHEJ; Ku; DNA-PK; Gene targeting; Telomeres; Human somatic cell lines
NHEJ protects mycobacteria in stationary phase against the harmful effects of desiccation
Keywords: DNA repair; NHEJ; Mycobacteria; Desiccation; Ku
2-Step purification of the Ku DNA repair protein expressed in Escherichia coli
Keywords: Ku; DNA-PK; Non-homologous end-joining; NHEJ