Do we really want to REACH out to in vitro?
Keywords: سلول های PC12; In vitro neurotoxicity; Testing strategies; PC12 cells; SH-SY5Y cells
مقالات ISI سلول های PC12 (ترجمه نشده)
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Involvement of IGF-I receptor and estrogen receptor pathways in the protective effects of ginsenoside Rg1 against Aβ25–35-induced toxicity in PC12 cells
Keywords: سلول های PC12; Ginsenoside Rg1; β-Amyloid peptide; Estrogen receptor; Insulin-like growth factor-I receptor; PC12 cells
MKP3 eliminates depolarization-dependent neurotransmitter release through downregulation of L-type calcium channel Cav1.2 expression
Keywords: سلول های PC12; Voltage-gated calcium channel; Gene expression; Map kinase; Signaling; Phosphatase; Exocytosis; pc12 cells
New analogs of the CART peptide with anorexigenic potency: The importance of individual disulfide bridges
Keywords: سلول های PC12; CART peptide analogs; Sulfitolysis; PC12 cells; Binding; Food intake
The roles of cyclic AMP–ERK–Bad signaling pathways on 6-hydroxydopamine-induced cell survival and death in PC12 cells
Keywords: سلول های PC12; 6-Hydroxydopamine; Cyclic AMP; Extracellular signal-regulated kinase (ERK); Bad; PC12 cells
Phosphatidylserine metabolism modification precedes manganese-induced apoptosis and phosphatidylserine exposure in PC12 cells
Keywords: سلول های PC12; Manganese; PC12 cells; Apoptosis; Phosphatidylserine; Phosphatidylserine synthase; Serine base exchange enzyme
Genomic cloning and promoter functional analysis of myostatin-2 in shi drum, Umbrina cirrosa: Conservation of muscle-specific promoter activity
Keywords: سلول های PC12; Myostatin-2; Promoter transcriptional activity; Reporter gene; Spliced and unspliced transcripts; Brain; C2 cells; PC12 cells; Umbrina cirrosa
Syntheses of structurally-simplified and fluorescently-labeled neovibsanin derivatives and analysis of their neurite outgrowth activity in PC12 cells
Keywords: سلول های PC12; QJQMAKPBUKQGHH-ABRRZJDOSA-N; WISNWCFAUUXHCB-SRVKXCTJSA-N; WISNWCFAUUXHCB-TUAOUCFPSA-N; YNJGXQUTVLYUEZ-QUJJFIQJSA-N; Neovibsanin derivative; Neurite outgrowth activity; PC12 cells; Fluorescent probe molecule; Structure-activity correlation;
Antidepressant-like effect of hyperoside isolated from Apocynum venetum leaves: Possible cellular mechanisms
Keywords: سلول های PC12; Hyperoside; Apocynum venetum; Antidepressant avtivity; Cytoprotective; PC12 cells; Corticosterone; Brain-derived neurotrophic factor; cAMP response element binding protein
Tellurium-nanowire-coated glassy carbon electrodes for selective and sensitive detection of dopamine
Keywords: سلول های PC12; Te nanowires; Dopamine; Differential pulse voltammetry; PC12 cells; Electrochemical detection
Inkjet printed polypyrrole/collagen scaffold: A combination of spatial control and electrical stimulation of PC12 cells
Keywords: سلول های PC12; Inkjet printing; Polypyrrole; PC12 cells; Cell spatial control; Electrical stimulation
Paraquat affects the homeostasis of dopaminergic system in PC12 cells
Keywords: سلول های PC12; Paraquat; Dopamine homeostasis; PC12 cells
Gallium nitride is biocompatible and non-toxic before and after functionalization with peptides
Keywords: سلول های PC12; Gallium nitride; Cellular adhesion; Surface functionalization; PC12 cells
Scabronine M, a novel inhibitor of NGF-induced neurite outgrowth from PC12 cells from the fungus Sarcodon scabrosus
Keywords: سلول های PC12; Nerve growth factor; Cyathane diterpenoids; Scabronine M; PC12 cells; Sarcodon scabrosus; Neurite outgrowth-inhibiting activity
Toxic cytological alteration and mitochondrial dysfunction in PC12 cells induced by 1-octyl-3-methylimidazolium chloride
Keywords: سلول های PC12; Ionic liquid; PC12 cells; Cytotoxicity; Mitochondrial dysfunction; Apoptosis;
Bone marrow-derived mesenchymal stem cells prevent the apoptosis of neuron-like PC12 cells via erythropoietin expression
Keywords: سلول های PC12; Bone marrow-derived mesenchymal stem cells; PC12 cells; Erythropoietin; Apoptosis; Neuronal stress;
Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress
Keywords: سلول های PC12; Hydroxycinnamic acid; Caffeic acid; Ferulic acid; Alkyl esters; Antioxidant; Redox properties; PC12 cells; Neuroprotection;
Research ReportIGF-1 induces hypoxia-inducible factor 1α-mediated GLUT3 expression through PI3K/Akt/mTOR dependent pathways in PC12 cells
Keywords: سلول های PC12; IGF-1; GLUT3; HIF-1α; (PI3K)/Akt/mTOR pathways; PC12 cells;
Dopamine release from rat pheochromocytoma (PC12) cells and rat brain striata induced by a series of straight carbon chain aldehydes with variations in carbon chain length and functional groups
Keywords: سلول های PC12; Dopamine; n-Aldehydes; n-Alcohols; PC12 cells; Rat striatum;
Tityus zulianus venom induces massive catecholamine release from PC12 cells and in a mouse envenomation model
Keywords: سلول های PC12; Epinephrine; Catecholamine release; Tityus zulianus; Tityus discrepans; Scorpion venoms; PC12 cells; Dopamine release; BSA; Bovine Serum Albumin; [Ca2+]i; Intracellular Ca2+ concentration; CC; Carbamylcholine; COMT; Catechol-Orto-Methyl Transferase; Epi;
ZnO nanowire arrays as substrates for cell proliferation and differentiation
Keywords: سلول های PC12; ZnO nanowires; PC12 cells; H9c2 cells; Nanostructured arrays
Chlorpyrifos developmental neurotoxicity: Interaction with glucocorticoids in PC12 cells
Keywords: سلول های PC12; ANOVA, analysis of variance; ChAT, choline acetyltransferase; NGF, nerve growth factor; TH, tyrosine hydroxylaseChlorpyrifos; Dexamethasone; Glucocorticoids; Organophosphate pesticides; PC12 cells; Preterm delivery
Modulatory effects of sesamin on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells
Keywords: سلول های PC12; Sesamin; Dopamine biosynthesis; l-DOPA-induced cytotoxicity; Cyclic AMP; PC12 cells
3-Thiomethyl-5,6-(dimethoxyphenyl)-1,2,4-triazine improves neurite outgrowth and modulates MAPK phosphorylation and HSPs expression in H2O2-exposed PC12 cells
Keywords: سلول های PC12; HSPs; MAPKs; Neurite outgrowth; PC12 cells; Triazine derivatives;
Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation
Keywords: سلول های PC12; ANOVA, analysis of varianceApoptosis; Cell cycle; Diazinon; Dieldrin; Nickel; PC12 cells
Adhesive proteins linked with focal adhesion kinase regulate neurite outgrowth of PC12 cells
Keywords: سلول های PC12; Adhesive proteins; Neurite outgrowth; PC12 cells; Focal adhesion kinase; Nerve regeneration;
MicroRNA expression profiling of NGF-treated PC12 cells revealed a critical role for miR-221 in neuronal differentiation
Keywords: سلول های PC12; miRNA; microRNA; 3â²-UTR; 3â²-untranslated region; AD; Alzheimer's diseases; NGF; nerve growth factor; MAPK; mitogen-activated protein kinase; DMEM; Dulbecco's modified Eagle's medium; HS; horse serum; FBS; fetal bovine serum; GEO; Gene Expression
Neuropharmacology and analgesiaInhibitory effect of selaginellin on high glucose-induced apoptosis in differentiated PC12 cells: Role of NADPH oxidase and LOX-1
Keywords: سلول های PC12; Selaginellin; High glucose; Lectin-like oxidized low density lipoprotein receptor-1; NADPH oxidase; Reactive oxygen species; PC12 cells;
Vitamin E renders protection to PC12 cells against oxidative damage and apoptosis induced by single-walled carbon nanotubes
Keywords: سلول های PC12; Single-walled carbon nanotube; Vitamin E; PC12 cells; ROS;
A proteomic approach to identification of plutonium-binding proteins in mammalian cells
Keywords: سلول های PC12; PC12 cells; IMAC; 2-D gel electrophoresis; LC-MS/MS; Plutonium-binding proteins; GO process;
Effects of extracellular calcium concentration on neurite outgrowth in PC12 cells by staurosporine
Keywords: سلول های PC12; Extracellular Ca2+; Neurite outgrowth; PC12 cells; Staurosporine;
Protective effects of peony glycosides against corticosterone-induced cell death in PC12 cells through antioxidant action
Keywords: سلول های PC12; Peony glycosides; Antidepressant; Corticosterone; PC12 cells; Neuroprotection; Antioxidant;
Cell cycle markers have different expression and localization patterns in neuron-like PC12 cells and primary hippocampal neurons
Keywords: سلول های PC12; Cyclin; Cdk; Hippocampal neurons; PC12 cells
Neuroprotective effects of Abacopterin E from Abacopteris penangiana against oxidative stress-induced neurotoxicity
Keywords: سلول های PC12; Neuroprotective effects; PC12 cells; Neurotoxicity; Long-term potentiation (LTP); Free radicals;
Visfatin induces neurite outgrowth in PC12 cells via ERK1/2 signaling pathway
Keywords: سلول های PC12; CoCl2; ERK1/2; Neurite outgrowth; PC12 cells; Visfatin;
Interaction of plasma membrane Ca2+-ATPase isoform 4 with calcineurin A: Implications for catecholamine secretion by PC12 cells
Keywords: سلول های PC12; Calcineurin; PMCA isoforms; Dopamine secretion; PC12 cells;
Protective effect of trifluoperazine on hydrogen peroxide-induced apoptosis in PC12 cells
Keywords: سلول های PC12; Trifluoperazine; H2O2; Oxidative stress; Reactive oxygen species (ROS); Apoptosis; PC12 cells
Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells
Keywords: سلول های PC12; EGF-R; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; nAChR; nicotinic acetylcholine receptor; NO; nitric oxide; nNOS; neuronal nitric oxide synthase; PKC; protein kinase C; PKG; prote
Protective effect of diosmin on LPS-induced apoptosis in PC12 cells and inhibition of TNF-α expression
Keywords: سلول های PC12; Diosmin; Lipopolysaccharide (LPS); PC12 cells; Apoptosis; Neuroinflammation; Neurodegeneration; TNF-α
Overexpression of the human ubiquitin E3 ligase CUL4A alleviates hypoxia-reoxygenation injury in pheochromocytoma (PC12) cells
Keywords: سلول های PC12; Ubiquitin E3 ligase; CUL4A; Gene overexpression; Hypoxia; Reoxygenation; PC12 cells;
Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+: The involvement of PI3K/Akt pathway activation
Keywords: سلول های PC12; Parkinson's disease; Tetrahydroxystilbene glucoside; Neuroprotection; PC12 cells; Apoptosis; PI3K/Akt signaling pathway;
Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-κB activation
Keywords: سلول های PC12; Ginsenoside Rg1; PC12 cells; H2O2; Oxidative stress; NF-κB pathway
2-Ethoxy-4,5-diphenyl-1,3-oxazine-6-one activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death
Keywords: سلول های PC12; Alzheimer's disease; Apoptosis; Nrf2; Oxazine derivative; Oxidative stress; PC12 cells
Differentiation of PC12 cells induced by N8-acetylspermidine and by N8-acetylspermidine deacetylase inhibition
Keywords: سلول های PC12; APAH, 7-[N-(3-aminopropyl)-amino]-heptan-2-one; DAH, 1,7-diaminoheptane; NGF, nerve growth factor.Polyamine; N8-Acetylspermidine; N8-Acetylspermidine deacetylase; APAH; Cell growth; Differentiation; Dopamine; PC12 cells
A novel method for producing mono-biotinylated, biologically active neurotrophic factors: An essential reagent for single molecule study of axonal transport
Keywords: سلول های PC12; Nerve growth factor; Biotinylation; Quantum dots; Single molecule imaging; Axonal transport; Microfluidic nerve cell chamber; PC12 cells; Dorsal root ganglion; Signaling pathways; Receptors
7-Ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways
Keywords: سلول های PC12; 7-Ketocholesterol; PC12 cells; Reactive oxygen species; NF-κB; Akt pathway; Apoptosis-related proteins
Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells
Keywords: سلول های PC12; Nrf2; Keap1; Nitric oxide; Nitrosative stress; Nitrosylation; PC12 cells
CART peptide stimulation of G protein-mediated signaling in differentiated PC12 Cells: Identification of PACAP 6–38 as a CART receptor antagonist
Keywords: سلول های PC12; CART; CART peptide; CART receptor; CART binding; GPCR; PC12 cells; PACAP 6–38
Mono-(2-ethylhexyl) phthalate impairs neurodevelopment: Inhibition of proliferation and promotion of differentiation in PC12 cells
Keywords: سلول های PC12; MEHP; DEHP; Developmental neurotoxicity; Proliferation; Differentiation; PC12 cells
Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: Role played by PLC-γ, IP3 receptors
Keywords: سلول های PC12; Papaverine; Neurite outgrowth; PLC-γ; IP3 receptors; PDE10A; PC12 cells