An algorithm for the simulation of the growth of root systems on deformable domains
Keywords: Density models; PDE; Deformable domain; Root architecture; Barley;
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Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte
Keywords: AKAP; A kinase anchoring protein; ARVM; adult rat ventricular myocyte; β-AR; beta adrenoceptor; C3SD; caveolin-3 scaffolding domain; cAMP; cyclic adenosine 3â²-5â²-monophosphate; Cav-3; caveolin-3; CGP; CGP20712A; EHNA; erythro-9-(2-hydroxy-3-nonyl)ade
Positive feedback in the Akt/mTOR pathway and its implications for growth signal progression in skeletal muscle cells: An analytical study
Keywords: Akt/mTOR; Skeletal muscle; Positive feedback; PDE; Analytical solutions
Contact drying: A review of experimental and mechanistic modeling approaches
Keywords: APIs; active pharmaceutical ingredients; DEM; discrete element method; DPM; distributed parameter models; GC; gas chromatography; HPLC; high performance liquid chromatography; KF; Karl Fischer; LOD; loss on drying; LPM; lumped dynamic models; NIR; near-in
A perspective on PSE in pharmaceutical process development and innovation
Keywords: ANN; artificial neural network; API; active pharmaceutical ingredient; CAMD; computer-aided molecular design; CFD; computational fluid dynamics; CP; continuous processing; CPM; continuous pharmaceutical manufacturing; CPP; critical process parameter; CQA;
2012 Update to The Society of Thoracic Surgeons Guideline on Use of Antiplatelet Drugs in Patients Having Cardiac and Noncardiac Operations
Keywords: ACC; American College of Cardiology; ACS; acute coronary syndrome; ADP; adenosine diphosphate; AHA; American Heart Association; CABG; coronary artery bypass graft surgery; COX; cyclooxygenase; CYP; cytochrome P450; GP; glycoprotein; ICU; intensive care un
Human cyclic nucleotide phosphodiesterases possess a much broader substrate-specificity than previously appreciated
Keywords: PDE; phosphodiesterase; AMP; adenosine 5â²-monophosphate; GMP; guanosine 5â²-monophosphate; CMP; cytidine 5â²-monophosphate; UMP; uridine 5â²-monophosphate; IMP; inosine 5â²-monophosphate; XMP; xanthosine 5â²-monophosphate; TMP; thymidine 5â²-monop
N-Acylhydrazones as inhibitors of PDE10A
Keywords: PDE10; PDE10A; Phosphodiesterase; Schizophrenia; Hydrazide; PDE; Enzyme inhibitor; Hydrazone; Acylhydrazone
Local signals with global impacts and clinical implications: Lessons from the plasma membrane calcium pump (PMCA4)
Keywords: PMCA; plasma membrane calcium/calmodulin dependent ATPase; SERCA; sarco/endoplasmic reticulum calcium ATPase; SPCA; secretory pathway calcium ATPase; PDZ; PSD 95, Drosophila Discs large protein and Zona occludens-1; MAGUK; membrane-associated guanylate ki
Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids
Keywords: 5-HT; 5-hydroxytryptamine; n; adenosine receptor; AT; angiotensin receptor; BZD; benzodiazepine; B2; bradykinin receptor; CGRP; calcitonin gene related peptide; CB; cannabinoid receptor; CCK; cholecystokinin; Dn; dopamine receptors; EHNA; erythro-9-(2-hyd
Metal ion stimulators of PDE5 cause similar conformational changes in the enzyme as does cGMP or sildenafil
Keywords: PDE; cyclic nucleotide phosphodiesterase; PAGE; polyacrylamide gel electrophoresis; SDS; sodium dodecyl sulfate; KPEM; 10 mM potassium phosphate (pH 6.8) containing 1 mM EDTA and 25 mM β-mercaptoethanol; GAF; cGMP-binding PDE, Anabaenaadenylyl cyclase
How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
Keywords: cAMP; cyclic adenosine monophosphate; CNC; Carney complex; CS; Cushing syndrome; CREB; cAMP response element-binding; MAH; micronodular adrenocortical hyperplasia; PDE; phosphodiesterases; PKA; protein kinase A; PPNAD; primary pigmented nodular adrenocort
Astma i otyÅoÅÄ - czy można mówiÄ o wspólnych uwarunkowaniach genetycznych tych chorób?
Keywords: astma; otyÅoÅÄ; genetyka; GWAS - badania asocjacji genomu; badania genów-kandydatów; bronchial asthma; obesity; GWAS - genome-wide association study; ACE; angiotensin converting enzyme-enzym konwertujÄ
cy angiotensynÄ; ADR; adrenergic receptor-r
Evaluation of Early Imaging Response After Chemoembolization of Hepatocellular Carcinoma by Phosphorus-31 Magnetic Resonance Spectroscopy-Initial Experience
Keywords: HCC; hepatocellular carcinoma; NTP; nucleoside triphosphates; 31P; phosphorus-31; PCr; phosphocreatine; PDE; phosphodiesters; %NTP/TPC; percent change in NTP/TPC ratio; %PDE/NTP; percent change in PDE/NTP ratio; Pi; inorganic phosphate; PME; phosphomonoes
Cyclic AMP-mediated immune regulation - Overview of mechanisms of action in T cells
Keywords: AC; Adenylyl cyclase; AKAP; A-kinase anchoring protein; AKAP-KL; AKAP-kidney lung; AKB; A-kinase binding domain; AP-1; Activator protein 1; ATF; Activation transcription factor; C; Catalytic (subunit of PKA); CBP; CREB-binding protein; CNG; Cyclic nucleot
Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene
Keywords: NO; nitric oxide; ICER; inducible cAMP early repressor; RPaSMC; rat pulmonary artery smooth muscle cells; VSMC; vascular smooth muscle cells; PKG; cGMP-dependent protein kinase; sGC; soluble guanylate cyclase; sGCα1â/â; mice deficient for the soluble
Moving carbonation fronts in concrete: A moving-sharp-interface approach
Keywords: pde; partial differential equation; ode; ordinary differential equation; RD; reaction-diffusion; FEM; finite element method; Carbonation; Modeling; Moving-interface problem; Fast reaction; Finite element method; Large-time behavior;
Zinc-desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa
Keywords: AMD; age-related macular degeneration; AREDS; age-related eye disease study; BSA; bovine serum albumin; CAT; catalase; DFO; desferrioxamine; ERG; electroretinogram; Ga/DFO; gallium-desferrioxamine complex; GPX; glutathione peroxidase; HO1; heme oxygenas
Hair removal methods: A comparative study for dermoscopy images
Keywords: Skin cancer; Dermoscopy; Melanoma; Hair segmentation; Linear interpolation; Image inpainting; PDE; Fast marching
PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: A key step in parkinsonism physiopathology
Keywords: cAMP; adenosine 3â², 5â²-cyclic monophosphate; cGMP; guanosine 3â²,5â²-cyclic monophosphate; PDE; 3â²,5â²-cyclic nucleotide phosphodiesterases; MSN; medium spiny neurons; PDE10A; phosphodiesterase 10A; PDE1B; phosphodiesterase 1B; 6-OHDA; 6-hydroxyd
Digestibility, methane production and nitrogen balance in sheep fed ensiled or fresh mixtures of sorghum-soybean forage
Keywords: Sorghum; Soybean; Ensiling; Bag and fecal digestibility; ADF; acid detergent fiber; CP; crude protein; DCPSI; digestible crude protein in small intestine; DE; digestible energy; DM; dry matter; DMI; dry matter intake; ERD; effectively rumen degraded; FM;
2-(2-Fluorobenzamido)benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ dysfunction in rats
Keywords: AC; adenylate cyclase; AKT; protein kinase B; cAMP; cyclic adenosine 3â²,5â²-monophosphate; CB; cytochalasin B; EFB-1; 2-(2-fluorobenzamido)benzoic acid ethyl ester; FMLP; formyl-l-methionyl-l-leucyl-l-phenylalanine; GPCR; G-protein-coupled receptor; IB
Estimating the influence of U.S. ethanol policy on plant investment decisions: A real options analysis with two stochastic variables
Keywords: DDGS; distillers dried grains with soluble; VEETC; volumetric ethanol excise tax credit; ROA; real options analysis; GBM; geometric Brownian motion; ODE; ordinary differential equation; PDE; partial differential equation; FOB; free on board pricing; ADF;
Pain and analgesia: The dual effect of nitric oxide in the nociceptive system
Keywords: 7-NI; 7-nitroindazole; AA; arachidonic acid; Ach; acetylcholine; AG; aminoguanidine hemisulfate; AKT; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATP; adenosine triphosphate; CFA; complete Freund's adjuvant; cGMP; cycl
DFT/B3LYP study of the substituent effect on the reaction enthalpies of the individual steps of single electron transfer-proton transfer and sequential proton loss electron transfer mechanisms of chroman derivatives antioxidant action
Keywords: DFT; density functional theory; ZPE; zero point energy; IP; ionization potential; PDE; proton dissociation enthalpy; PA; proton affinity; ETE; electron transfer enthalpy; SET-PT; single electron transfer followed by proton transfer; SPLET; sequential pr
Spatial attrition modeling: Stability conditions for a 2D+t2D+t FD formulation
Keywords: PDE; Stability; Reaction–diffusion; Spatial attrition modeling
Toxicological evaluation of a dietary supplement formulated for male sexual health prior to market release
Keywords: ANOVA; analysis of variance; API; active pharmaceutical ingredient; bDNA; branched deoxyribonucleic acid; CA; chromosomal aberration; cGMP; current good manufacturing practices; DMEM; Dulbecco's Modified Eagle's Medium; DMSO; dimethyl sulfoxide; FBS;
Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues
Keywords: Phosphodiesterase; PDE; Real-time PCR; Gene expression; Tissue distribution; cGMP; cAMP
Symbolic computation of solutions for a forced Burgers equation
Keywords: Nonlinear evolution equation; pde; Burgers equation; Reaction-diffusion equation;
Comparison of PDE based and other techniques for speckle reduction from digitally reconstructed holographic images
Keywords: Digital holography; Speckle noise; Coherent imaging; Homomorphic filtering; PDE; Diffusion filters and performance comparison
Analysis and interpretation of residence time distribution experimental curves in FM01-LC reactor using axial dispersion and plug dispersion exchange models with closed–closed boundary conditions
Keywords: FM01-LC; RTD; ADM; PDE; Closed–closed boundary
Pro-inflammatory responses in human monocytes are β1-adrenergic receptor subtype dependent
Keywords: ARs; adrenergic receptors; Bmax; maximal specific binding of radioligand; CGP 20712A; [1-(2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazoylyl)phenoxy)-2-propanol methanesulfonate, 2-hydroxy-5-(2-(hydroxy-3-(4-((1-m
Cirrhotic cardiomyopathy
Keywords: ANP; atrial natriuretic peptide; BNP; B-type natriuretic peptide; CO; carbon monoxide; CB1; cannabinoid-1-receptor; Gαi; inhibitory G-protein; Gαs; stimulatory G-protein; HO; haemoxygenase; HRS; hepatorenal syndrome; l-NAME; l-nitro-arginine-methyl-este
Methylxanthine reversal of opioid-evoked inspiratory depression via phosphodiesterase-4 blockade
Keywords: Breathing; Caffeine; PDE; Respiratory rhythm; Rolipram; Theophylline
Differential distribution of exchange proteins directly activated by cyclic AMP within the adult rat retina
Keywords: PKA; immunohistochemistry; PDE; CNG; Rap; H89; BCA; bicinchoninic acid; cAMP; cyclic AMP; cDNA; complimentary DNA; cGMP; cyclic guanosine monophosphate; ChAT; choline acetalytransferase; CNB; cyclic nucleotide binding site; CNG; cyclic nucleotide gated ch
A nonlinear PDE formulation for offshore vessel pipeline installation
Keywords: Pipeline installation; PDE; Nonlinear; Modeling; Passivity; RIFLEX; FEM
Effects of rolipram on adult rat oligodendrocytes and functional recovery after contusive cervical spinal cord injury
Keywords: 3â²-5â²-cyclic adenosine monophosphate; magnetically evoked interenlargement responses; locomotion; neuroprotection; phosphodiesterase 4; transcranial magnetic motor evoked potentials; APC; adenomatus polyposis coli; BBB; Basso, Beattie, and Bresnahan;
New abundant solutions for the Burgers equation
Keywords: Nonlinear evolution equation; PDE; Burgers equation
Allosteric-site and catalytic-site ligand effects on PDE5 functions are associated with distinct changes in physical form of the enzyme
Keywords: PDE; cyclic nucleotide phosphodiesterase; IBMX; 3-isobutyl-1-methylxanthine; C domain; catalytic domain; R domain; regulatory domain; PAGE; polyacrylamide gel electrophoresis; KP; 10Â mM potassium phosphate (pH 6.8); GAF; cGMP-binding PDE, Anabaenaadenyly
PDE-based unsupervised repair of hair-occluded information in dermoscopy images of melanoma
Keywords: Malignant melanoma; Closing-based top-hat operator; Image inpainting; PDE; Elongate function
Phosphodiesterases link the aryl hydrocarbon receptor complex to cyclic nucleotide signaling
Keywords: ARA9; AIP; PDE; cAMP; cGMP; Dioxin
Distinct actions of strontium on mineral formation in matrix vesicles
Keywords: BCIP; bromo-chloro-indolyl phosphate; HA; hydroxyapatite; MV; matrix vesicle; NBT; nitroblue tetrazolium; PAGE; polyacrylamide gel electrophoresis; pMV; pellet of PI-PLC treated MV; PI-PLC; phosphatidylinositol phospholipase C; PDE; phosphodiesterase; PME
Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages
Keywords: AA; arachidonic acid; AK; protein kinase A; AM; alveolar macrophages; ANF; atrial naturetic factor; BSA; bovine serum albumin; EIA; enzyme-linked immunoassay; 5-LO; 5-lipoxygenase; FLAP; 5-lipoxygenase activating protein; GC; guanylyl cyclase; GK; protein
YC-1 attenuates homotypic human neutrophil aggregation through inhibition of phosphodiesterase activity
Keywords: Aggregation; cAMP; Neutrophil; PDE; YC-1
Scalable purification and characterization of the extracellular domain of human autotaxin from prokaryotic cells
Keywords: ATX; LysoPLD; PDE; NPP2; Recombinant protein; Metastasis
Construction of blending surfaces by parametric discrete interpolation PDE splines
Keywords: 65D07; 65D10; 65D17Surfaces; PDE; Boundary value problem; Interpolation; Finite elements
Real-time monitoring of phosphodiesterase inhibition in intact cells
Keywords: PDE; Inhibitor; cAMP; cGMP; FRET;
Bacopa monniera ameliorates amnesic effects of diazepam qualifying behavioral-molecular partitioning
Keywords: amnesia; benzodiazepine; behavioral-molecular; Bacopa monniera; diazepam; water maze; cAMP; cyclic adenosine monophosphate; CREB; cAMP response element binding protein; ELT; escape latency time; ERK; extracellular signal-regulated kinase; iNOS; inducible
Low doses of cyclic AMP-phosphodiesterase inhibitors rapidly evoke opioid receptor-mediated thermal hyperalgesia in naïve mice which is converted to prominent analgesia by cotreatment with ultra-low-dose naltrexone
Keywords: AC; adenylyl cyclase; β-FNA; β-funaltrexamine; cAMP; cyclic AMP; CTX-B; cholera toxin-B subunit; GM1; monosialoganglioside; IBMX; 3-isobutyl-1-methylxanthine; NLX; naloxone; NTX; naltrexone; nor-BNI; nor-binaltorphimine; PDE; phosphodiesterase; PKA; pro
Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets
Keywords: PDE; cAMP; Pancreatic islets; Type 2 diabetes