
Production of reactive oxygen species by withaferin A causes loss of type collagen expression and COX-2 expression through the PI3K/Akt, p38, and JNK pathways in rabbit articular chondrocytes
Keywords: پروستاگلاندین E2; WFA; withaferin A; ROS; reactive oxygen species; COX-2; cyclooxygenase-2; PGE2; prostaglandin E2; NAC; N-acetyl-l-cysteine; OA; osteoarthritis; ECM; extracellular matrix; PI3K/Akt; phosphatidylinositol 3-kinase; MAPK; mitogen-activated protein kinase; JNK