Keywords: Actin dynamics; Rho GTPases; dendritic spines; postsynapse; Abi-1; Abelson interacting protein 1; Abp1; actin binding protein 1; ACTN4; α-actinin-4; ADF; actin-depolymerizing factor; ADHD; attention deficit/hyperactivity disorder; ADNP; activity-dependen
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Keywords: AC; adenylyl cyclase; ALG-2; apoptosis-linked gene 2 product; Alix; ALG-2-interacting protein X; Bcl10; B-cell lymphoma/leukemia protein 10; CaM; calmodulin; CaM-BD; CaM-binding domain; CaM-BP; CaM-binding protein; CARD; caspase-recruitment domain; Carma1
Keywords: ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; CLL; B-cell chronic lymphocytic leukemia; CML; chronic myelogenous leukemia; ERK; extracellular signal-regulated kinase; FN3; fibronectin type-III (domain); GBM; glioblastoma multiforme; JMML
Keywords: PTP; protein tyrosine phosphatase; PTK; protein tyrosine kinase; LMW-PTP; low molecular weight protein tyrosine phosphatase; LMW-AP; low molecular weight acid phosphatase; ACP1; gene coding for human LMW-PTP; PTP1B; tyrosine-protein phosphatase non-recept
Keywords: ACI; Autologous chondrocyte implantation; ACPCs; Articular cartilage progenitor cells; ASCs; Adipose stem cells; BMP; Bone morphogenetic protein; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma-extra large; BCA-1; B cell-attracting chemokine 1; CCR6;
Association between SHANK3 polymorphisms and susceptibility to autism spectrum disorder
Keywords: ASD; Autism spectrum disorder; SNPs; single nucleotide polymorphisms; CHB; Han Chinese in Beijing population; MAF; minimum allele frequency; PCR; polymerase chain reaction; iMLDR; improved multiplex ligation detection reaction; HWE; Hardy-Weinberg equilib
The role of TRPV4 in fibrosis
Keywords: α-SMA; α-smooth muscle actin; aa; amino acids; AHF; alcohol/high fat diet; AIP4; atrophin-interacting protein 4; ANK; ankyrin; ARS-L; arachidonate-like recognition sequence; ASL; airway surface liquid; BKCa; Ca2 +-dependent K+; [Ca2 +]i; intracellular
Role of the Crumbs proteins in ciliogenesis, cell migration and actin organization
Keywords: AJ; adherens junction; TJ; tight junction; aPKC; atypical protein kinase C; CRB; crumbs; DLG; discs large; ECM; extracellular matrix; FERM; 4.1 ezrin radixin moesin; LGL; lethal giant larvae; MAGUK; membrane-associated guanylate kinase; MUPP1; multi PDZ d
Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells
Keywords: Abl; ableson kinase; ABR; actin binding repeat; Arg; ableson related gene kinase; Arp2/3; actin related protein 2/3; ATAT1; alpha-tubulin N-acetyltransferase 1; DMEM; Dulbecco's modified Eagle's medium; DOX; doxycycline; Erk; extracellular signal-re
Ca2+ signaling and Src-kinases-controlled cellular functions
Keywords: Ca2+ channels; Cell signaling; Phosphatases; Receptors; Src-family kinases; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxyli
Organizers and activators: Cytosolic Nox proteins impacting on vascular function
Keywords: AIR; Autoinhibitory region; cAMP; Cyclic adenosine mono-phosphate; HUVEC; Human umbilical vein endothelial cells; LPS; Lipopolysaccharide; PI3K; Phosphatidyl inosite 3-kinase; PKA; Protein kinase A; PKC; Protein kinase C; PMN; Polymorph-nuclear neutrophil
A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation
Keywords: Shh; Sonic hedgehog; BOC; Brother of CDO; CDO; cell adhesion molecular downregulated by ocogenes; JNK; Jun N-terminal kinase; EC; embryonal carcinoma cell; NPC; neural progenitor cell; DCC; deleted in colorectal cancer; ROBO; roundabout; GLI; glioma-assoc
Identification of two novel SH3PXD2B gene mutations in Frank-Ter Haar syndrome by exome sequencing: Case report and review of the literature
Keywords: PMSA; Protein multiple sequence alignments; FTHS; Frank-Ter Haar syndrome; WES; Whole Exome Sequencing; SH3; Src homology3; Frank-Ter Haar syndrome; SH3PXD2B; Whole exome sequencing;
Comparative transcriptomic analyses of male and female adult Toxocara canis
Keywords: ALG; apoptosis-linked gene; BTB; broad/complex/tramtrack/bric a brac; CCR4; C-C chemokine receptor type 4; CEH; carboxylesterase 1; CRN; cell death related nuclease; CSR; chromosome segregation protein; DPY; dumpy; EH; eclosion hormone; Elk-1; ets-like pr
The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: A triple threat in the regulation of the neuronal cytoskeleton
Keywords: AD; Alzheimer disease; CaM; calmodulin; CNA/B; calcineurin A/B subunit; Glu-MTs; detyrosinated microtubules; GSK3β; glycogen synthase kinase 3β; MAP; microtubule-associated protein; MARCKS; myristoylated alanine-rich C-kinase substrate; MT; microtubule;
The C1 domain of Vav3, a novel potential therapeutic target
Keywords: DAG; diacylglycerol; PKC; protein kinase C; GEF; guanine nucleotide exchange factor; PMA; phorbol 12-myristate 13-acetate; PDBu; phorbol 12,13-dibutyrate; CH domain; calponin homology domain; AD; acidic domain; DH; Dbl homology; PH; Pleckstrin homology; S
Molecular characterization and expression analysis of olive flounder (Paralichthys olivaceus) phospholipase C gamma 1 and gamma 2
Keywords: Phospholipase C gamma 1 (PLCG1); Phospholipase C gamma 2 (PLCG2); Olive flounder; Paralichthys olivaceus; cDNA cloning; mRNA expression; PLC; phosphoinositide-specific phospholipase C; PKC; protein kinase C; PLCG; phospholipase C gamma; SH2; Src homology
Structure-function studies of MICAL, the unusual multidomain flavoenzyme involved in actin cytoskeleton dynamics
Keywords: MICAL; Flavoprotein; FAD-containing monooxygenase/oxidase; F-actin depolymerization; Semaphorin signaling; Cytoskeleton; ABS; actin binding site; CasL; Crk (p38)-associated substrate-related protein; CC; coiled-coils; CH; calponin homology; CRMP; collapsi
The SH3 domain distinguishes the role of I-BAR proteins IRTKS and MIM in chemotactic response to serum
Keywords: IRTKS; MIM; SH3; p38; Small GTPases; Cell migration; Cell morphology;
Pervanadate induces Mammalian Ste20 Kinase 3 (MST3) tyrosine phosphorylation but not activation
Keywords: Cys; cysteine; DMEM; Dulbecco's modified Eagle's medium; EGFR; epidermal growth factor receptor; GPCR; G protein-coupled receptor; HEK 293; human embryonic kidney 293; HPK1; hematopoietic progenitor kinase 1; MST; mammalian Ste20 kinase; MAP4K; MAP kinase
Binding of a proline-independent hydrophobic motif by the Candida albicans Rvs167-3 SH3 domain
Keywords: SH3; Src-homology 3; BAR; Bin-Amphiphysin-RVS; Candida albicans; Rvs167-3; SH3 domain; Non-canonical ligand; Proline-independent binding;
The role of connexin43-Src interaction in astrocytomas: A molecular puzzle
Keywords: Cx43; connexin43; Cx43CT; C-terminal domain of connexin43; GLUT-3; glucose transporter-3; GSC; glioma stem cells; HIF; hypoxia-inducible factor; HK2; type II hexokinase; IDP; intrinsically disordered protein; IDR; intrinsically disordered region; MAPK; mi
ADAMs family and relatives in cardiovascular physiology and pathology
Keywords: ADAM; A disintegrin and metalloproteinase; ADAM-TS; ADAM with thrombospondin domains; APP; amyloid precursor protein; APPsα; α-secretase-released N-terminal APP domain; C-domain; cysteine-rich domain; COMP; cartilage oligomeric matrix protein; DCM; dila
Dynamin2 GTPase contributes to invadopodia formation in invasive bladder cancer cells
Keywords: Dynamin; Invadopodia; Bladder cancer; Cortactin; Actin; Arp2/3; actin related protein 2 and 3; WASP; Wiskott-Aldrich Syndrome protein; WIP; WASP-interacting protein; MMP2/9; matrix metalloprotease 2 and 9; MT1-MMP; membrane type-I matrix metalloprotease;
The Paracaspase MALT1
Keywords: NF-κB signaling; Protease; Caspase; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1); ABC; activated B cell-like; ABC-DLBCL; activated B cell-like diffuse large B cell lymphoma; Ac; acetyl; ALL; acute lymphomblastic leukemia; AM
Cool-temperature-mediated activation of phospholipase C-γ2 in the human hereditary disease PLAID
Keywords: PLC; inositol-phospholipid-specific phospholipase C; SH2; Src homology domain 2; SH3; Src homology domain 3; PH; pleckstrin homology domain; spPH; split PH domain; PCI; phospholipase C inhibitor peptide; Rac; Ras-related C3 botulinum toxin substrate; BCR;
Palmitoylation in Alzheimerâ¿¿s disease and other neurodegenerative diseases
Keywords: ABCA1; ATP-binding cassette transporter A1; AD; Alzheimer⿿s disease; ADAM17; a disintegrin and metalloproteinase 17; AICD; APP intracellular domain; AKAP79; A-kinase anchoring protein 79; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; APP; amy
Phospholipase Cβ1b directly binds the SH3 domain of Shank3 for targeting and activation in cardiomyocytes
Keywords: Scaffold protein; Cardiomyocyte; Hypertrophy; Localization; NRVM; neonatal rat ventricular myocytes; PDZ; post synaptic density protein, drosophila disc large tumor suppressor, and zonula occludens-1 protein; PLC; phospholipase C; SH3; Src homology domain
Quantitative comparison of CrkL-SH3 binding proteins from embryonic murine brain and liver: Implications for developmental signaling and the quantification of protein species variants in bottom-up proteomics
Keywords: Quantitative proteomics; CrkL; Crk; SH3; C3G; Splice variants; Protein species variants
The atypical 'b' splice variant of phospholipase Cβ1 promotes cardiac contractile dysfunction
Keywords: DGKζ; diacylglycerol kinase ζ; FS; fractional shortening; LVIDd; left ventricular internal diameter at diastole; LVIDs; left ventricular internal diameter at systole; LVPWd; left ventricular posterior wall thickness at diastole; LVPWs; left ventricular
SASH1, a new potential link between smoking and atherosclerosis
Keywords: Atherosclerosis; SASH1; Smoking; CCND3; CCND1; TP53; HAECs; human aortic endothelial cells; HCASMCs; human coronary artery smooth muscle cells; SASH1; SAM and SH3 domain containing 1; SAM; sterile alpha-motif; SH3; Src-homology 3; WST-1; (4-[3-(4-iodophen
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members
Keywords: 5-HT; 5-hydroxytryptamine, serotonin; A549; non-small cell lung cancer cell line; AD; Alzheimer's disease; ADPKD; autosomal dominant polycystic kidney disease; Aire; autoimmune regulator; AP-1; activator protein 1; APP; amyloid precursor protein; AREB6; Z
STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons
Keywords: STAM; signal transducing adaptor molecule; VHS domain; Vps-27/Hrs/Stam domain; UIM; ubiquitin-interacting motif; SH3; Src homology 3; CC; coiled coil; SSM; STAM-specific motif; ITAM; immunoreceptor tyrosine-based activation motif; HRS; hepatocyte growth f
Fascin actin bundling controls podosome turnover and disassembly while cortactin is involved in podosome assembly by its SH3 domain in THP-1 macrophages and dendritic cells
Keywords: Arp; actin-related protein; CORNb; anti-cortactin nanobody; DC; dendritic cells; EGFP; enhanced green fluorescent protein; FASNb; anti-fascin nanobody; GELNb; anti-gelsolin nanobody; GM-CSF; granulocyte macrophage colony-stimulating factor; HS1; hematopoi
Arabidopsis dynamin-related proteins, DRP2A and DRP2B, function coordinately in post-Golgi trafficking
Keywords: BiFC; bi-molecular fluorescent complementation; CLSM; confocal laser scanning microscopy; CoIP-MS; co-immunoprecipitation mass spectrometry; DRP; dynamin-related protein; GED; GTPase-effector domain; Lat B; latrunculin B; ORY; oryzalin; PH; pleckstrin hom
Spatial and temporal expression of RA70/Scap2 in the developing neural tube
Keywords: Retinoic acid; SKAP55; Scap; Neural tube; Integrin; BAC; bacterial artificial chromosome; CC; coiled-coil; EC; embryonic carcinoma; ES; embryonic stem; IRES; internal ribosome entry sites; Neo; neomycin resistance; PH; pleckstrin homology; RA; retinoic ac
Molecular determinants of the interaction between Doa1 and Hse1 involved in endosomal sorting
Keywords: Doa1; Hse1; PFU; SH3; Interaction; Endosomal sorting;
The ASAP2 gene is a primary target of 1,25-dihydroxyvitamin D3 in human monocytes and macrophages
Keywords: 1,25(OH)2D3 or 1,25D; 1α,25-dihydroxyvitamin D3; ADAM17; ADAM metallopeptidase domain 17; Arf; ADP-ribosylation factor; ASAP2; Arf-GAP with SH3 domain, ankyrin repeat and PH domain 2; B2M; beta-2-microglobulin; ChIA-PET; chromatin interaction analysis wi
Mutant huntingtin replaces Gab1 and interacts with C-terminal SH3 domain of growth factor receptor binding protein 2 (Grb2)
Keywords: HD; Huntington's disease; Htt; huntingtin; Grb2; growth factor receptor binding protein 2; Sos1; Son of Sevenless homolog 1; Gab1; Grb2 associated binding protein 1; SH2; Src homology 2; SH3; Src homology 3; N-SH3; N-terminal SH3 domain; C-SH3; C-terminal
P21-activated kinase in inflammatory and cardiovascular disease
Keywords: AID; Auto-inhibitory domain; ATP; Adenosine-triphosphate; B-cell; B lymphocytes; BLNK; B cell linker protein; CaM; Calmodulin; Cdc; Cell division control protein; cyt b558; Flavocytochrome b558; DUOX1/2; Dual oxidase 1/2; EF hand motif; Helix-loop-helix s
PELP1: A review of PELP1 interactions, signaling, and biology
Keywords: AIB1; amplified in breast cancer 1; AR; androgen receptor; BCAS3; breast carcinoma amplified sequence 3; CBP; CREB binding protein; ChIP; chromatin immunoprecipitation; E2; estradiol; ER; estrogen receptor; ERRα; estrogen-related receptor alpha; FHL2; fo
Molecular basis of the binding of YAP transcriptional regulator to the ErbB4 receptor tyrosine kinase
Keywords: WW-ligand thermodynamics; PPXY motifs; Structural analysis; Conformational dynamics; ErbB4; erythroblastic (Erb) leukemia viral oncogene homolog B4; ITC; isothermal titration calorimetry; ITCH; ubiquitin ligase itchy homolog; LIC; ligation-independent clo
Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos
Keywords: aa; amino acids; Akt/PKB; protein kinase B; Ank; ankyrin repeats; AO; Acridine orange; BrdU; 5-bromo-2â²-deoxyuridine; EGFP; enhanced GFP; Erk; extracellular signal-regulated kinases; HEK; human embryonic kidney; hpf; hour post fertilization; IGF-IR; IGF
Ral small GTPase signaling and oncogenesis: More than just 15Â minutes of fame
Keywords: CAAX; cysteine-aliphatic-aliphatic-terminal amino acid; DMBA; 7,12-dimethylbenz[α]anthracene; EGF; epidermal growth factor; EH; Eps homology; ER; endoplasmic reticulum; GAP; GTPase activating protein; GEF; guanine nucleotide exchange factor; ICMT; isopre
Spectrins: A structural platform for stabilization and activation of membrane channels, receptors and transporters
Keywords: PH; pleckstrin homology domain; ABD; actin binding domain; SH3; SRC homology 3 domain; EF-hand domain; calcium-binding domain; PIP2; Phosphatidylinositol 4,5-bisphosphate; CH1; calponin homology domain; PKA; Protein Kinase-A; cAMP; 3â²-5â²-cyclic adenos
Structural basis for recognition of the third SH3 domain of full-length R85 (R85FL)/ponsin by ataxin-7
Keywords: Atx7; ataxin-7; polyQ; polyglutamine; PRR; proline-rich region; R85FL; full-length R85; SCA7; spinocerebellar ataxia 7; SH3; Src homology 3; Ataxin-7; Proline-rich region; R85FL/ponsin; SH3 domain; Polyglutamine; Inclusion body;
Two distinct mechanisms by which phospholipase C-γ1 mediates epidermal growth factor-induced keratinocyte migration and proliferation
Keywords: EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; Cai; intracellular calcium; NHK; normal human keratinocytes; PLC; phospholipase C; PLC-β1; phospholipase C-β1; PLC-γ1; phospholipase C-γ1; PLC-δ1; phospholipase C-δ1; PI3K; phosph
Competitive binding of UBPY and ubiquitin to the STAM2 SH3 domain revealed by NMR
Keywords: ESCRT; endosomal sorting complexes required for transport; Ub; monoubiquitin; UIM; ubiquitin interacting motif; SH3; Src homology 3 domain; UBD; ubiquitin binding domain; MVB; multivesicular body; Hrs; hepatocyte growth factor-regulated substrate; STAM; s
Phosphosite conservation in single domain orthologs versus paralogs: A way to combine differential regulation with redundant core functions
Keywords: EST; expressed sequence tag; ADF; actin depolymerizing factor; EVH; Ena/VASP homology; PtdIns(4,5)P2; 1-(3-sn-Phosphatidyl)-d-myo-inositol 4,5-bis(phosphate); SH2; src homology 2; SH3; src homology 3; Single domain protein; Sequence conservation; Actin bi
The application of modular protein domains in proteomics
Keywords: pTyr; phosphotyrosine; PTM; post-translational modification; MS; mass spectrometry; PSSM; position specific scoring matrix; SH2; Src homology 2; SH3; Src homology 3; WW; tryptophan tryptophan; PDZ; post synaptic density protein 95-disks large protein 4-zo