Regulation of endothelial lipase and systemic HDL cholesterol levels by SREBPs and VEGF-A
Keywords: SREBP; HDL; Endothelial lipase; VEGF-A;
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Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells
Keywords: ABC; ATP-binding cassette transporter; FAS; fatty acid synthase; HDL; high-density lipoprotein; LBD; ligand-binding domain; LDL; low-density lipoprotein; LXR; liver X receptor; NPC1L1; Niemann-Pick C1 Like 1; SCD-1; stearoyl-CoA desaturase 1; SPR; surface
Side-chain oxysterols: From cells to membranes to molecules
Keywords: ACAT; acyl-CoA cholesterol acyl transferase; CF; carboxyfluorescein; DOPC; dioleolyphosphatidylcholine; DPPC; dipalmitoylphosphatidylcholine; HC; hydroxycholesterol; LXR; liver X receptor; POPC; 1-palmitoyl-2-oleoyl-phosphatidylcholine; Scap; SREBP cleava
Knockout of SOD1 alters murine hepatic glycolysis, gluconeogenesis, and lipogenesis
Keywords: AMPK; AMP-activated protein kinase; GK; glucokinase; GPX1; Se-glutathione peroxidase 1; JNK2; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MS; metabolic syndrome; NEFA; nonesterified fatty acid; PEPCK; phosphoenolpyruvate carboxykina
PPARs: Fatty acid sensors controlling metabolism
Keywords: AF; activation function; AMPK; AMP-activated protein kinase; BAT; brown adipose tissue; C/EBPα; CCAAT-enhancer binding protein α; DBD; DNA binding domain; FA; fatty acid; FAO; FA oxidation; HAT; histone acetyl transferase; HFD; high fat diet; GSIS; gluc
Indinavir inhibits the expression of cytoplasmic aromatase and nuclear SREBP in the hippocampus of reperfusion injury-induced ischemic rats
Keywords: Aromatase; SREBP; Indinavir sulfate; Megestrol acetate; Transient global ischemia; Carotid artery occlusion; Rat
Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model
Keywords: ER; endoplasmic reticulum; TM; tunicamycin; NASH; non-alcoholic steatohepatitis; NAFLD; non-alcoholic fatty liver disease; TG; triglycerides; SREBP; sterol responsive binding protein; NF-κB; activation of nuclear factor-kappa B; IκB; NF-κB inhibitor; E
Delineation of molecular pathways that regulate hepatic PCSK9 and LDL receptor expression during fasting in normolipidemic hamsters
Keywords: PCSK9; LDLR; SREBP; HNF1α; PPARα; LXR; LDL-cholesterol; Fasting; Golden Syrian hamsters;
Dancing with the sterols: Critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis
Keywords: ABC; ATP Binding Cassette; AICAR; Aminoimidazole Carboxamide Ribonucleotide; ApoE; Apolipoprotein E; ApoER2; ApoE receptor 2 (LRP8); AR; Androgen Receptor; BAC; Bacterial Artificial Chromosome; CETP; Cholesterol Ester Transfer Protein; eNOS; endothelial N
Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of statins?
Keywords: AFCAPS/TexCAPS; Air Force/Texas Coronary Atherosclerosis Prevention Study; ARMYDA; Atorvastatin for Reduction of MYocardial Damage during Angioplasty; ASCOT-LLA; The Anglo-Scandinavian Cardiac Outcomes Trial- Lipid-Lowering Arm; AURORA; A Study to Evaluat
Does endoplasmic reticulum stress participate in APD-induced hepatic metabolic dysregulation?
Keywords: Antipsychotic drugs; Lipid and cholesterol synthesis; SREBP; ER stress; PERK pathway; IHHABCA1, Adenosine triphosphate-Binding Cassette transporter A1; APD, Antipsychotic Drug; ATF3, Activating Transcription factor 3; ATF4, Activating Transcription factor
Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review
Keywords: PUFAn-3; PPAR; SREBP; Cholesterol; Functional foods
Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease
Keywords: Diagnosis; Epidemiology; Cancer Risk; Mechanisms; ALT; alanine aminotransferase; APOC3; apolipoprotein C3; ARFI; acoustic radiation force impulse elastography; AST; aspartate aminotransferase; ATF6; activating transcription factor-6; AUROC; area under the
Compensatory increase in lipogenic gene expression in adipose tissue of transgenic mice expressing constitutively active AMP-activated protein kinase-alpha1 in liver
Keywords: AMPK; SREBP; Transgenic mice; Lipogenic gene expression; Adipose tissue;
Research ArticlePathogenesis of lipid metabolism disorder in hepatitis C: Polyunsaturated fatty acids counteract lipid alterations induced by the core protein
Keywords: HCV; hepatitis C virus; HCC; hepatocellular carcinoma; PUFA; polyunsaturated fatty acids; PPAR; peroxisome proliferators-activated receptors; SREBP; sterol regulatory element binding protein; EPA; eicosapentaenoic acid; AA; arachidonic acid; ETYA; eicosat
Docosapentaenoic acid (22:5n-3): A review of its biological effects
Keywords: n-3 Polyunsaturated fatty acids (VLCPUFA); Eicosapentaenoic acid (EPA); Docosapentaenoic acid (DPA); Docosahexaenoic acid (DHA); AA; arachidonic acid; ACC; Acetyl CoA Carboxylase; ALA; alpha linolenic acid; BAE; bovine aortic endothelial cells; ChREBP; ca
Perspectives on endocrine disruptor effects on metabolic sensors
Keywords: EDs; endocrine disruptors; DEHP; dietylexilphthalate; DDT; dichloro-diphenyl-trichloroethane; DES; diethylstilbestrol; BPA; bisphenol A; PCBs; polychlorinated biphenyls; TCDD; tetrachlorodibenzo-p-dioxin; HxCDD; hexachlorodibenzo-p-dioxin; PEPCK; phosphoe
Urban planning of the endoplasmic reticulum (ER): How diverse mechanisms segregate the many functions of the ER
Keywords: ACS4/FACL4; acyl-CoA synthase 4; ACAT/SOAT; acyl-CoA cholesteryl acyl transferase; AMFR; autocrine motility factor receptor; BAP31; B-cell receptor-associated protein of 31Â kDa; BiP; immunoglobulin binding protein; CHOP; CCAAT/enhancer binding protein (C
Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis
Keywords: Lipotoxicity; LRH-1; Bsep; Liver Damage; ABC; adenosine triphosphate-binding cassette; ACAT; acyl-CoA cholesterol/cholesteryl transferase; BA; bile acid; Bsep; bile salt export pump; CE; cholesteryl ester; Cyp; cytochrome P450; FC; free cholesterol; FFA
Sterol metabolism and SREBP activation
Keywords: Sterol metabolism; SREBP; HMG CoA reductase; SCAP; Insig; ABCA1; TRC8
Transcriptional factors that promote formation of white adipose tissue
Keywords: Adipocyte; PPAR; C/EBP; STAT5; KLF; SREBP
Candidate gene markers involved in San Daniele ham quality
Keywords: Genetic markers; SREBP; SCAP; S1P; MBPTS1; SCD; Association; Pig; Dry-cured ham
Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners
Keywords: BMMCs; bone marrow-derived mast cells; FcεRI; high-affinity IgE; LXR; liver X receptor; LDLR; LDL receptor; 25-OHC; 25-hydroxycholesterol; 22(R)-OHC; 22(R)-hydroxycholesterol; 24(S),25-EC; 24(S),25-epoxycholesterol; 22(S)-hydroxycholesterol; (22(S)-OHC);
Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARα)
Keywords: ABC; ATP-binding cassette; ACC; Acetyl-Coenzyme A carboxylase; BADGE; Bayesian Analysis of Differential Gene Expression; CPT; Carnitine palmitoyltransferase; CT; CTP:phosphocholine cytidylyltransferase; DHA; docosahexaenoic acid; FAS; fatty acid synthase;
Dietary polyunsaturated fatty acids slow the progression of diabetic nephropathy in streptozotocin-induced diabetic rats
Keywords: Alb; albumin; DML; diabetic rats fed a lard diet containing saturated fatty acids; DMR; diabetic rats fed 1a rapeseed oil diet containing polyunsaturated fatty acid; FA; fatty acid; FFA; free fatty acid; Glc; glucose; NL; nontreated rats fed a lard diet;
Altered lipoprotein metabolism in P2Y13 knockout mice
Keywords: GPR86; P2ry13; HDL; Gene expression profiling; Reverse Cholesterol Transport; SREBP
Cholesterol synthesis in the lactating cow: Induced expression of candidate genes
Keywords: Cholesterol; HMG-CoA reductase; HMG-CoA synthase; SREBP; Scap;
Atherogenic diet leads to posttranslational down-regulation of murine hepatocyte SR-BI expression
Keywords: SR-BI; PDZK1; Cholesterol; Mouse; SREBP; Liver; Posttranslational regulation
Regulation of steroid 5-α reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin
Keywords: Srd5a2; Steroid 5-α reductase type 2; SREBP; sterol regulatory element binding protein; HMG; 3-hydroxy-3-methylglutaryl; ChIP; chromatin immunoprecipitation; qPCR; quantitative PCR; L/E; lovastatin and ezetimibe; LDLR; low density lipoprotein receptor; S
Bax inhibitor-1 overexpression reduces the suppressive effect of calcium mobilizing agent on adipogenesis
Keywords: BI-1; Bax inhibitor-1; ER; endoplasmic reticulum; SERCA; sarco-endoplasmic reticulum Ca2+-ATPase; HA; hemagglutinin; THAP; thapsigargin; TUN; tunicamycin; DTT; dithiothreitol; GRP78; 78Â kDa glucose-regulated protein; XBP-1; X-box binding protein-1; eIF2Î
Special relationship between sterols and oxygen: Were sterols an adaptation to aerobic life?
Keywords: CHO; Chinese hamster ovary; DHCR24; 3β-hydroxysterol-Î24-reductase; EPR; electron paramagnetic resonance; ESR; electron spin resonance; H2O2; hydrogen peroxide; HIF-1α; hypoxia-inducible factor 1α; HMG-CoA reductase; 3-hydroxy-3-methyl-glutaryl-coenzy
Transcriptional regulation of mitochondrial glycerophosphate acyltransferase is mediated by distal promoter via ChREBP and SREBP-1
Keywords: Glycerophosphate acyltransferase; Mitochondria; Promoter; Luciferase; EMSA; ChIP; ChREBP; SREBP; Transcriptional regulation
Modulation of the hepatic fatty acid pool in peroxisomal 3-ketoacyl-CoA thiolase B-null mice exposed to the selective PPARalpha agonist Wy14,643
Keywords: Peroxisomal 3-ketoacyl-CoA thiolase B; PPARα; Mono-unsaturated fatty acids n-7 and n-9; Stearoyl-CoA desaturase-1; Wy14,643; ThB; peroxisomal 3-ketoacyl-CoA thiolase B; ThA; peroxisomal 3-ketoacyl-CoA thiolase A; ACOX-I; peroxisomal acyl-CoA oxidase-I; P
Hypoxia and the metabolic phenotype of prostate cancer cells
Keywords: ALDO; aldolase; CS; citrate synthase; COX; cytochrome c oxidase; DCA; dichloroacetate; G3PDH; glyceraldehyde-3-phosphate dehydrogenase; G6PDH; glucose-6-phosphate dehydrogenase; HK; hexokinase; HIF; hypoxia-inducible factor; LDH; lactate dehydrogenase; NR
New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
Keywords: ACAT; acyl-CoA:cholesterol acyltransferase; ABC; adenosine triphosphate-binding cassette transporter; ANXA2-CAV1; annexin 2/caveolin 1; apo; apolipoprotein; CVD; cardiovascular disease; CYP7A1; cytochrome P450 family 7 subfamily A polypeptide 1; FPPS; f
Anandamide modulates growth and lipid metabolism in the zebrafish Danio rerio
Keywords: Endocannabinoids; AM251; CB1; IGFs; SREBP
Treatment with LXR agonists after focal cerebral ischemia prevents brain damage
Keywords: LXR; liver X receptor; ABCA1; ATP-binding cassette A1; SREBP; sterol regulated-element binding protein; MRI; magnetic resonance imaging; Acute cerebral ischemia; Experimental therapy; Neuroprotection; Nuclear receptor; Transcriptional activator;
Cyclic AMP-dependent proteolysis of GATA-6 expressed on the intracellular membrane
Keywords: cAMP; A-kinase; GATA-6; SREBP; Proteolysis; CHO-K1; BSA; bovine serum albumin; dbcAMP; dibutyryl cAMP; DIG; digoxigenine; DMSO; dimethyl sulfoxide; EEA1; early endosomal antigen 1; ER; endoplasmic reticulum; H-89; N-[2-((p-bromocinnamyl)amino)ethyl]-5-iso
Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice
Keywords: AMPK-alpha1; Transgenic mice; SREBP; Liver gene expression
Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosis
Keywords: HCV; hepatitis C virus; SREBP; sterol regulatory element binding protein; HBV; hepatitis B virus; NDL; non-diseased liver; FAS; fatty acid synthase; GPAT; glycerol-3-phosphate acyltransferase; BMI; body mass index; GAPDH; glyceraldehyde-3-phosphate dehydr
Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae
Keywords: Ergosterol; UPC2; ECM22; SREBP; Azole resistance; GFP; FACS; Post-translational regulation;
SREBP-2 and SCAP isoforms and risk of early onset myocardial infarction
Keywords: Myocardial infarction; Early-onset; SCAP; SREBP; Genetic polymorphism; Gene–gene interaction
Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis
Keywords: Acc-1; acetyl CoA carboxylase 1; DTg; double transgenic; Fae; long-chain free fatty acid elongase; Fas; fatty acid synthase; FFA; free fatty acid; HA; hemagglutinin; LXR; liver X receptor; PCN; pregnenolone-16α-carbonitrile; PPAR; peroxisome proliferator
Membrane phospholipids, lipoxidative damage and molecular integrity: A causal role in aging and longevity
Keywords: AA; arachidonic acid; AKR; aldo-keto reductase; ALDH; aldehyde dehydrogenase; ALEs; advanced lipoxidation end-product; ARE; antioxidant response element; CBP; CREB-binding protein; CR; caloric restriction; CREB; cAMP-responsive element-binding factor; DBI
Aminopyrrolidineamide inhibitors of site-1 protease
Keywords: Site-1 protease; SREBP; Sterol regulatory element binding protein; Metabolic syndrome
Transcriptional downregulation of sterol metabolism genes in murine liver exposed to acute hypobaric hypoxia
Keywords: High-altitude; Acute hypobaric hypoxia; Sterol; SREBP
Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolism
Keywords: Mevalonate kinase; Cob(I)alamin adenotransferase; Cholesterol; SREBP; Atorvastatin
Curcumin induces changes in expression of genes involved in cholesterol homeostasis
Keywords: Curcumin; Cholesterol; LDL receptor; SREBP; Liver X receptor; Retinoic acid response element; Alkaline phosphatase
Inability to fully suppress sterol synthesis rates with exogenous sterol in embryonic and extraembyronic fetal tissues
Keywords: SLOS; Smith-Lemli-Opitz syndrome; DHCR7; 3β-hydroxysterol Î7-reductase; HMGR; HMG-CoA reductase; SREBP; sterol regulatory element binding protein; SCAP; SREBP cleavage-activating protein; DPS; digitonin-precipitable sterols; Shh; Sonic hedgehog; Cho
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2
Keywords: SREBP; ER stress; UPR; Cholesterol; Caspases