Keywords: Resistin-like molecule; Macrophage; Helminth infection; T helper type 2; Toll-like Receptor 4; ABC; ATP-binding cassette transporter; ADD1; adipocyte determination and differentiation dependent factor 1; ADSF; adipocyte secreted factor; Akt (aka PKB); pro
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Keywords: Pattern-recognition receptors (PRRs); Toll-like receptors (TLRs); RIG-I-like receptors (RLRs); NOD-like receptors (NLRs); Small molecule modulators; BIR; baculovirus inhibitor repeat; CARD; caspase recruitment domains; CFS; chronic fatigue syndrome; CLR;
Keywords: Motor neuron disease; Amyotrophic lateral sclerosis; TBK1; NEK1;
Keywords: ABIN; A20 binding and inhibitor of NF-κB; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; Atg; autophagy-related gene; C9ORF72; chromosome 9 open reading frame 72; CC; coiled-coil; cIAP; cellular inhibitor of apoptosis protein; CYLD; cylin
Keywords: AP1; Activator protein 1; cAMP; Cyclic adenosine monophoshate; CXCR; Cytokine receptors; CRTH2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; DAMPs; Damage-associated molecular pattern; EtBr; Ethidium Bromide; IgE; Immunoglobulin E;
Keywords: APAP; acetaminophen; ALD; alcoholic liver disease; BAG4; Bcl2-associated athanogene 4; CCCP; carbonyl-cyanide m-chlorophenyl hydrazine; Clec16a; c-type lectin domain family 16, member A; Dfcp1; double FYVE-containing protein 1; DUB; deubiquitinating enzym
Keywords: ACP5; Acid phosphatase 5; ADAR1; Adenosine deaminase RNA-specific 1; AGS; Aicardi-Goutières syndrome; ALRs; AIM2-like receptors; AIM2; Absent in melanoma 2; ASC; Apoptosis-associated speck-like protein containing a CARD; CANDLE; Chronic atypical neutroph
Keywords: Hantavirus; Interferon; Pathogenesis; Endothelial cell; Permeability; TBK1;
Keywords: ACOX-1; acyl-CoA oxidase 1; AdipoQ; adiponectin; BCE; black currant extract; CD68; cluster of differentiation 68; CLS; crown-like structures; CTP-1; carnitine palmotyoltransferase 1; CVD; cardiovascular disease; DIO; diet-induced obesity; FAS; fatty acid
Keywords: AIM2; absent in melanoma 2; AP-1; activating protein-1; APOBEC; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like; AZT; azidothymidine; CCCR5; C-C chemokine receptor type 5; CDK1; cyclin-dependent kinase 1; CXCR4; C-X-C chemokine receptor t
Keywords: AP-1; jun proto-oncogene; BAI3; brain-specific angiogenesis inhibitor 3; CADM2; cell adhesion molecule 2; CAGE; cap analysis of gene expression; cDNA; DNA complementary to RNA; ChIP; chromatin immunoprecipitation; FGF14; fibroblast growth factor 14; GADD4
Keywords: ACTDs; autoimmune connective tissue diseases; SLE; systemic lupus erythematosus; RA; rheumatoid arthritis; SSc; systemic sclerosis; SS; Sjögren's syndrome; MCTD; mixed connective tissue disease; TLRs; IL-1R-like receptors; DAMPs; danger-associated molecu
SIKE of black carp is a substrate of TBK1 and suppresses TBK1-mediated antiviral signaling
Keywords: SIKE; Black carp; TBK1; GCRV; SVCV; Innate immunity;
Beyond ALS and FTD: the phenotypic spectrum of TBK1 mutations includes PSP-like and cerebellar phenotypes
Keywords: TBK1; PSP; Ataxia; Whole-exome sequencing; Genetic screening; FTD;
Mycobacterium tuberculosis ESAT6 induces IFN-β gene expression in Macrophages via TLRs-mediated signaling
Keywords: RD1; Region of difference 1; ESAT6; 6-kDa early secretory antigen target; ESX-1; ESAT6 system-1; CFP10; 10-kDa culture filtrate protein; Type I IFNs; Type I interferons; TBK1; TANK-binding kinase; IRF; Interferon regulatory factor; BMDMs; Bone marrow-deri
TBK1: A key regulator and potential treatment target for interferon positive Sjögren's syndrome, systemic lupus erythematosus and systemic sclerosis
Keywords: Interferon; TBK1; Sjögren's syndrome; Systemic lupus erythematosus; Systemic sclerosis;
Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort
Keywords: Early onset Alzheimer's disease; TBK1; Loss-of-function; Frontotemporal dementia; RNA sequencing;
The binding of TBK1 to STING requires exocytic membrane traffic from the ER
Keywords: STING; TBK1; Membrane traffic; Endoplasmic reticulum; The Golgi; Autoinflammatory disease;
Molecular epidemiological study of familial amyotrophic lateral sclerosis in Japanese population by whole-exome sequencing and identification of novel HNRNPA1 mutation
Keywords: Familial amyotrophic lateral sclerosis; HNRNPA1; TBK1; VCP; Whole-exome sequencing analysis; Stress granule;
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation
Keywords: ORMDL3; orosomucoid 1-like protein 3; GWAS; genome-wide association studies; EBV; Epstein-Barrvvirus; HRV; human rhinovirus; RSV; respiratory syncytial virus; STING; Stimulator of interferon genes; TLR; Toll-like receptors; NF-κB; nuclear factor κB; IFN
Andrographolide suppresses TRIF-dependent signaling of toll-like receptors by targeting TBK1
Keywords: Toll-like receptors; Andrographolide; Inflammation; TRIF; TBK1;
Functional characterization of duck TBK1 in IFN-β induction
Keywords: TBK1; Duck; IFN-β; Innate immunity;
Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction
Keywords: TBK1; IKKε; Obesity; Insulin; Insulin resistance; Metabolism;
Identification of a splice variant of optineurin which is defective in autophagy and phosphorylation
Keywords: Autophagy; Optineurin; TBK1; Phosphorylation; Atg16L1;
Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies
Keywords: NF-κB; nuclear factor kappa B; AP-1; activator protein; STAT3; signal transducer and activator of transcription 3; NK cells; natural killer cells; TNF-α; tumor necrosis factor-α; NO; nitric oxide; iNOS; inducible nitric oxygen synthase; ROS; reactive o
IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease
Keywords: Asthma; house dust mite; glycolysis; IL-1; inhibitor of κB kinase ε; lactate; lactate dehydrogenase A; AHR; Airways hyperresponsiveness; BAL; Bronchoalveolar lavage; BMI; Body mass index; DC; Dendritic cell; 2-DG; 2-Deoxyglucose; ECAR; Extracellular aci
ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function
Keywords: ALS; TBK1; FTD; WES; Familial ALS;
Neuregulin 1 discovered as a cleavage target for the HCV NS3/4A protease by a microfluidic membrane protein array
Keywords: HCV; hepatitis C virus; HCC; hepatocellular carcinoma; NS; nonstructural protein; TIR; toll/interleukin 1 receptor; TRIF; (TIR)-domain-containing adapter-inducing interferon-β; IIR; innate immune response; RIG-I; retinoic acid inducible gene; MAVS; mitoc
TBK1 from orange-spotted grouper exerts antiviral activity against fish viruses and regulates interferon response
Keywords: Grouper; TBK1; Iridovirus; Nodavirus; Antiviral activity; Interferon;
Frequency and characteristics of the TBK1 gene variants in Japanese patients with sporadic amyotrophic lateral sclerosis
Keywords: Amyotrophic lateral sclerosis; Sporadic; Japan; TBK1; Variant;
Optineurin Insufficiency Disbalances Proinflammatory and Anti-inflammatory Factors by Reducing Microglial IFN-β Responses
Keywords: ALS; amyotrophic lateral sclerosis; BMDM; bone marrow-derived macrophages; C9orf72; chromosome 9 open-reading frame 72; CNS; central nervous system; CXCL; CXC chemokine ligand; DAMPs; damage-associated molecular patterns; DMEM; Dulbecco's Modified Eagle
Nontypeable Haemophilus influenzae DNA stimulates type I interferon expression via STING signaling pathway
Keywords: NTHI; IFN-β; STING; TBK1; IRF3; cGAS;
Ctenopharyngodon idella TBK1 activates innate immune response via IRF7
Keywords: IRF7; TBK1; TLR; Innate immunity; Teleost;
Ca2+ signaling and Src-kinases-controlled cellular functions
Keywords: Ca2+ channels; Cell signaling; Phosphatases; Receptors; Src-family kinases; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxyli
Human microglia and astrocytes express cGAS-STING viral sensing components
Keywords: AMP; adenosine monophosphate; ATCC; American type tissue collection; ANOVA; analysis of variance; BDNA; B-form DNA; CNS; central nervous system; cDNA; complementary DNA; cGAS; cyclic GMP-AMP synthase; DAI; DNA-dependent activator of interferon-regulatory
Research paperSTRAP positively regulates TLR3-triggered signaling pathway
Keywords: STRAP; serine/threonine kinase receptor associated protein; TLR; Toll-like receptor; IFN; interferon; IRF; IFN regulatory factor; TBK1; TANK binding kinase 1; TRAF; TNF receptor associated factor; TAK1; transforming growth factor β-activated kinase 1; ST
The clinical, neuroanatomical, and neuropathologic phenotype of TBK1-associated frontotemporal dementia: A longitudinal case report
Keywords: TBK1; Neurogenetics; Neuropathology; Frontotemporal dementia;
IL-17 axis accelerates the inflammatory progression of obese in mice via TBK1 and IKBKE pathway
Keywords: Obesity; IL-17; TBK1; Il-17; interleukin-17; TBK1; tank binding kinae-1; IKBKE; IκB kinase subunit epsilon;
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection
Keywords: acLDL; acylated LDL; AIM2; absent in melanoma 2; AP-1; activator protein 1; BDCA-2; blood DC antigen; BEC; biliary epithelial cells; CARD; caspase recruitment and activation domains; cDC; common dendritic cells; CL-L1; collectin liver 1; CL-K1; collectin
Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure
Keywords: IFN I; type I interferon(s); IFI16; interferon-inducible protein 16; cGAMP; cyclic GMP-AMP; cGAS; cGAMP synthase; STING; stimulator of interferon genes; TBK1; TANK-binding kinase 1; IRF3; interferon regulatory factor 3; ISG; interferon-stimulated genes; P
The anticancer functions of RIG-I-like receptors, RIG-I and MDA5, and their applications in cancer therapy
Keywords: 5â²PP; 5â²-diphosphate; 5â²ppp; 5â²triphosphorylated; Bcl2; B-cell lymphoma-2; BIRC3; baculoviral IAP repeat-containing 3; CARDs; caspase activation and recruitment domains; CRC; colorectal cancer; CTD; C-terminal domain; CTLs; cytotoxic T lymphocytes
TBK1 of black carp plays an important role in host innate immune response against SVCV and GCRV
Keywords: TBK1; Black carp; Innate immunity;
Genetic and functional analysis of TBK1 variants in Korean patients with sporadic amyotrophic lateral sclerosis
Keywords: Amyotrophic lateral sclerosis; Gene; Pathogenic; TBK1; Variant;
Zebrafish STAT6 negatively regulates IFNÏ1 production by attenuating the kinase activity of TANK-binding kinase 1
Keywords: STAT6; Negative regulator; Interferon; TBK1; Zebrafish; CIP; calf intestinal phosphatase; CPE; cytopathic effect; EPC; epithelioma papulosum cyprini; GAS; interferon gamma activated sequence; IFN; interferon; IRF; IFN regulatory factor; IRF3; interferon r
TBK1 is associated with ALS and ALS-FTD in Sardinian patients
Keywords: Amyotrophic lateral sclerosis; Genetics; Sporadic; TBK1;
Mutational analysis of TBK1 in Taiwanese patients with amyotrophic lateral sclerosis
Keywords: Amyotrophic lateral sclerosis; ALS; TBK1; TANK-Binding kinase 1;
Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways
Keywords: IRF6; Positive regulator; Interferon; TBK1; MyD88CPE, cytopathic effect; DBD, DNA binding domain; EPC, epithelioma papulosum cyprini; IAD, IRF association domain; IFN, interferon; IRF, Interferon regulatory factor; ISG, IFN-stimulated gene; ISRE, IFN-stim
TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway
Keywords: Zebrafish; TBK1; TBK1-like transcript; RIG-I-Like receptors; IFN; Innate immune signaling
Murine gammaherpesvirus targets type I IFN receptor but not type III IFN receptor early in infection
Keywords: EBV; Epstein-Barr virus; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HHV-4; human herpesvirus 4; HHV-8; human herpesvirus 8; hpi; hours post infection; IFN; interferon; IFNAR; interferon α/β receptor; IFN-λR; interferon la
Human TBK1: A Gatekeeper of Neuroinflammation
Keywords: TBK1; autophagy; interferon; herpes simplex encephalitis; amyotrophic lateral sclerosis; dementia; glaucoma