کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10801885 | 1055647 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca2Â +-release channel
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کلمات کلیدی
CaMKIIANFBclPKCETARRyRIP3pKaSRFHDACAC6NFATsarco/endoplasmic reticulum Ca2 + ATPaseHECCa2 +/calmodulin-dependent protein kinase II - Ca2 + / calmodulin وابسته پروتئین کیناز IIinositol 1,4,5-trisphosphate - inositol 1،4،5-trisphosphateROS - ROSAkt/PKB - آکت / PKBopen probability - احتمال باز بودنSecretion - ترشح EMT - تکنسین فوریتهای پزشکیApoptosis - خزان یاختهایBcl-2 homology domain - دامنه هماهنگ Bcl-2Cancer - سرطانendoplasmic reticulum - شبکه آندوپلاسمی Nuclear Factor of Activated T Cells - عامل هسته ای سلول های T فعال شدهatrial natriuretic factor - فاکتور natriuretic دهلیزیserum response factor - فاکتور پاسخ سرمیSERCA - قلبHeart - قلب B-cell lymphoma - لنفوم سلول Bhistone deacetylase - هیستون داستیلازprotein kinase A - پروتئین کیناز Aprotein kinase B - پروتئین کیناز BProtein kinase C - پروتئین کیناز سیSenescence - پیریEpithelial-mesenchymal transition - گذار اپیتلیال-مزانشیمیReactive oxygen species - گونههای فعال اکسیژنendothelin receptor type A - گیرنده آندوتلین نوع ARyanodine receptor - گیرنده رایانودین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) type 2 (IP3R2) is an intracellular Ca2Â +-release channel located on the endoplasmic reticulum (ER). IP3R2 is characterized by a high sensitivity to both IP3 and ATP and is biphasically regulated by Ca2Â +. Furthermore, IP3R2 is modulated by various protein kinases. In addition to its regulation by protein kinase A, IP3R2 forms a complex with adenylate cyclase 6 and is directly regulated by cAMP. Finally, in the ER, IP3R2 is less mobile than the other IP3R isoforms, while its functional properties appear dominant in heterotetramers. These properties make the IP3R2 a Ca2Â + channel with exquisite properties for setting up intracellular Ca2Â + signals with unique characteristics. IP3R2 plays a crucial role in the function of secretory cell types (e.g. pancreatic acinar cells, hepatocytes, salivary gland, eccrine sweat gland). In cardiac myocytes, the role of IP3R2 appears more complex, because, together with IP3R1, it is needed for normal cardiogenesis, while its aberrant activity is implicated in cardiac hypertrophy and arrhythmias. Most importantly, its high sensitivity to IP3 makes IP3R2 a target for anti-apoptotic proteins (e.g. Bcl-2) in B-cell cancers. Disrupting IP3R/Bcl-2 interaction therefore leads in those cells to increased Ca2Â + release and apoptosis. Intriguingly, IP3R2 is not only implicated in apoptosis but also in the induction of senescence, another tumour-suppressive mechanism. These results were the first to unravel the physiological and pathophysiological role of IP3R2 and we anticipate that further progress will soon be made in understanding the function of IP3R2 in various tissues and organs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1853, Issue 9, September 2015, Pages 1992-2005
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1853, Issue 9, September 2015, Pages 1992-2005
نویسندگان
Tamara Vervloessem, David I. Yule, Geert Bultynck, Jan B. Parys,