کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2500836 1557311 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hybrid electrospun chitosan-phospholipids nanofibers for transdermal drug delivery
ترجمه فارسی عنوان
نانویی فیبر کیتوزان-فسفولیپید هیبرید الکترو اسپور برای تحویل داروی ترمیمی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Chitosan (Ch) polysaccharide was mixed with phospholipids (P) to generate electrospun hybrid nanofibers intended to be used as platforms for transdermal drug delivery. Ch/P nanofibers exibithed average diameters ranging from 248 ± 94 nm to 600 ± 201 nm, depending on the amount of phospholipids used. Fourier Transformed Infra-Red (FTIR) spectroscopy and Dynamic Light Scattering (DLS) data suggested the occurrence of electrostatic interactions between amine groups of chitosan with the phospholipid counterparts. The nanofibers were shown to be stable for at least 7 days in Phosphate Buffer Saline (PBS) solution. Cytotoxicity studies (WST-1 and LDH assays) demonstrated that the hybrid nanofibers have suitable biocompatibility. Fluorescence microscopy, also suggested that L929 cells seeded on top of the CH/P hybrid have similar metabolic activity comparatively to the cells seeded on tissue culture plate (control). The release of curcumin, diclofenac and vitamin B12, as model drugs, from Ch/P hybrid nanofibers was investigated, demonstrating their potential utilization as a transdermal drug delivery system.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 510, Issue 1, 20 August 2016, Pages 48–56
نویسندگان
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