کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2566523 | 1128085 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: A double blind study
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کلمات کلیدی
EPSPRLPANSSSchizophrenia - اسکیزوفرنی یا شیزوفرنیOlanzapine - الانزاپینANOVA - تحلیل واریانس Analysis of varianceone-way analysis of variance - تحلیل واریانس یک راههRigidity - سختیextrapyramidal side effects - عوارض جانبی ExtrapyramidalFluphenazine - فلوفنازینpositive and negative syndrome scale - مقیاس مثبت و منفی سندرمProlactin - پرولاکتین cortisol - کورتیزول
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Pharmacotherapy of schizophrenia is associated with the stressful side effects. Muscle rigidity causes distress, discomfort and poor compliance. The aim of the study was to determine the relationship between plasma hormones (cortisol and prolactin/PRL) and muscle rigidity in female schizophrenic patients treated with olanzapine or fluphenazine. In a randomized, double-blind 22-weeks study, 12 patients were treated with olanzapine (5-20Â mg/day) and 10 patients received fluphenazine (6-21Â mg/day). Treatment with olanzapine moderately decreased, while treatment with fluphenazine significantly increased plasma cortisol levels and muscle rigidity. The marked and moderate increase in plasma PRL levels were found in patients treated with fluphenazine and olanzapine, respectively. The results suggested that olanzapine induced moderate neuroendocrine effects and a reduction in rigidity as compared to fluphenazine treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 31, Issue 2, 30 March 2007, Pages 399-402
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 31, Issue 2, 30 March 2007, Pages 399-402
نویسندگان
M. Jakovljevic, N. Pivac, A. Mihaljevic-Peles, M. Mustapic, M. Relja, D. Ljubicic, D. Marcinko, D. Muck-Seler,