کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3199287 | 1201911 | 2010 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Primary immunodeficiencies may reveal potential infectious diseases associated with immune-targeting mAb treatments Primary immunodeficiencies may reveal potential infectious diseases associated with immune-targeting mAb treatments](/preview/png/3199287.png)
mAbs directed against immunologic molecules have emerged as a new class of drugs for treating patients with various immunologic conditions. However, mAb-based treatments may confer a predisposition to various infections. The authors argue that infections in individuals treated with mAbs directed against molecules of the immune system may display some similarities to those in patients with primary immunodeficiency of the corresponding mAb target. A comprehensive dissection of the tremendously diverse human primary immunodeficiencies and the careful description of their clinical features in different populations living in diverse environments thus represents an original, neglected, but promising approach to assessing the potential risk of infection associated with therapeutic mAbs, or with any therapeutic compound inhibiting a specific immunologic molecule.
Journal: Journal of Allergy and Clinical Immunology - Volume 126, Issue 5, November 2010, Pages 910–917