Eosinophilic gastrointestinal disease and peanut allergy are alternatively associated with IL-5+ and IL-5− TH2 responses

TH2 responses are composed of 2 subpopulations: IL-5+ TH2 and IL-5- TH2 cells. IL-5+ TH2 food allergen-specific T cells are singularly associated with AEG, whereas PA is associated with a dominant IL-5- TH2 response. These results suggest heterogeneity within the TH2 cytokine response, with different TH2 responses alternatively favoring IgE-mediated or eosinophil-dominant immunopathology.