کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3202756 | 1201978 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Specific oral tolerance induction in children with very severe cow's milk–induced reactions Specific oral tolerance induction in children with very severe cow's milk–induced reactions](/preview/png/3202756.png)
BackgroundSome children allergic to cow's milk proteins (CMPs) experience exceptionally severe reactions after ingesting only trace amounts of antigen. Avoiding the food and carrying self-injectable epinephrine are the current strategies for their management.ObjectiveThe aim of this study was to evaluate the safety and efficacy of specific oral tolerance induction (SOTI) for children with severe CMP-induced systemic reactions.MethodsNinety-seven children aged 5 years or older with a history of severe allergic reactions and very high CMP-specific IgE levels were selected for a double-blind, placebo-controlled food challenge. Sixty had positive test results to very small amounts of milk and were randomly divided in 2 different groups. Thirty children (group A) immediately began SOTI, whereas the remaining 30 (group B) were kept on a milk-free diet and followed for 1 year.ResultsAfter 1 year, 11 (36%) of 30 children in group A had become completely tolerant, 16 (54%) could take limited amounts of milk (5-150 mL), and 3 (10%) were not able to complete the protocol because of persistent respiratory or abdominal complaints. In group B the result of the double-blind, placebo-controlled food challenge performed after a year was positive in all 30 cases (P < .001).ConclusionsIn this study SOTI was effective in a significant percentage of cases.
Journal: Journal of Allergy and Clinical Immunology - Volume 121, Issue 2, February 2008, Pages 343–347